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Establishment of imaging biomarker for thymic epithelial tumors

Research Project

Project/Area Number 16K10300
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKurume University

Principal Investigator

Sumi Akiko  久留米大学, 医学部, 講師 (20425200)

Co-Investigator(Kenkyū-buntansha) 藤本 公則  久留米大学, 医学部, 教授 (00199366)
安倍 秀幸  久留米大学, 大学病院, 医療技術員 (30624481)
池原 奈央子  久留米大学, 医学部, 助教 (70389295)
久原 麻子  久留米大学, 医学部, 助教 (80529272)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords胸腺上皮性腫瘍 / 画像診断 / CT / MRI / PET / 病期分類 / 病理組織分類 / 予後因子 / 病理所見 / 画像予後予測因子 / 組織分類 / 病理像
Outline of Final Research Achievements

Of approximately 200 thymic epithelial tumors, approximately 130 cases of CT image data and approximately 120 cases of MR image data were evaluated. We analyzed these image findings with WHO histological classification (revised 2015) and TNM staging system (proposed by ITMIG), and compared with surgical findings. As a result, CT and MR image findings of thymic epithelial tumors correlated with WHO histological classification (revised in 2015) and also reflected tumor invasiveness in TNM staging system (proposed by ITMIG). In addition, CT and MR image findings, which may be prognostic factors, and CT findings associated with surgical resection were also obtained.
In conclusion, CT and MR image findings of thymic epithelial tumors are useful for predicting preoperative histological and staging and prognosis.

Academic Significance and Societal Importance of the Research Achievements

国際肺癌学会(IASLC)の関連組織である国際胸腺悪性腫瘍研究グループ(ITMIG)は、新たな胸腺悪性腫瘍のTNM分類を提唱しているが、これまでの病期分類と同様に画像所見は加味されていないのが現状である。また、胸腺上皮性腫瘍は希少疾患であるため、詳細な画像所見について十分な検討が行われていない。これらのことを踏まえ、CTやMRIなどの画像所見の詳細な検討を行い、画像所見が組織分類と病期分類の予測、予後予測に有用であることを示すことができた。つまり、CTやMRIなどの画像診断は、組織型や病期分類、予後予測に有用であり、適切な確定診断法を選択でき臨床的に役立つ情報を与えることができたと考える。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2019 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (7 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Is there any consensus of long-term follow-up for incidental anterior mediastinal nodular lesions?2018

    • Author(s)
      Sumi A, Fujimoto K.
    • Journal Title

      Shanghai Chest

      Volume: 2 Pages: 97-97

    • DOI

      10.21037/shc.2018.12.01

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Editorial on “Distribution of malignant lymphomas in the anterior mediastinum: a singleinstitution study of 76 cases in Japan, 1997-2016”2018

    • Author(s)
      Sumi Akiko、Fujimoto Kiminori
    • Journal Title

      Mediastinum

      Volume: 2 Pages: 13-13

    • DOI

      10.21037/med.2018.03.02

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mature Cystic Teratoma With an Element of Hepatocellular Carcinoma in Anterior Mediastinum Magnetic Resonance-Pathologic Correlation.2017

    • Author(s)
      Sumi A, Nagata S, Zaizen M, Murakami D, Takamori S, Abe H, Tanikawa K, Fujimoto K.
    • Journal Title

      J Thorac Imaging

      Volume: 32 Issue: 6 Pages: 84-86

    • DOI

      10.1097/rti.0000000000000301

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Evaluation of Thymic Epithelial Tumors and Malignant Lymphomas in Anterior Mediastinum using MR Imaging.2019

    • Author(s)
      Sumi A, Kuhara A, Ebata T, Nagata S, Fujimoto K.
    • Organizer
      ARRS2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comparison of Maximum Standardized Uptake Values of Malignant Lymphomas with Other Anterior Mediastinal Tumors Using 18F-FDG PET.2019

    • Author(s)
      Kuhara A, Sumi A, Kurata S, Nagata S, Fujimoto K.
    • Organizer
      ARRS2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 拡散強調画像を用いた胸腺上皮性腫瘍と前縦隔悪性リンパ腫の画像所見の検討2019

    • Author(s)
      角 明子,近末智雅,藤本公則
    • Organizer
      第38回日本胸腺研究会
    • Related Report
      2018 Research-status Report
  • [Presentation] CT Features of Thymic Epithelial Tumors: Correlation with New WHO Histologic Classification and TNM Staging Systems2017

    • Author(s)
      Sumi Akiko, Fujimoto Kiminori, Kuhara Asako, Ikehara Naoko, Iwamoto Ryoji, Sadohara Junko, Nagata Shuji, Abe Toshi
    • Organizer
      第77回日本医学放射線学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] CT Features of Thymic Epithelial Tumors: Correlation with the Clinical stage classification using the recently proposed TNM staging system2017

    • Author(s)
      Akiko Sumi, Kiminori Fujimoto, Asako Kuhara, Atsushi Kawaguchi, Naoko Ikehara, Shuji Nagata, Toshi Abe
    • Organizer
      第103回北米放射線学会
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] CT Diagnosis for Thymic Epithelial Tumors: Correlation with the World Health Organization histologic classification system updated in 2015 and new TNM staging system2016

    • Author(s)
      Akiko Sumi, Kiminori Fujimoto, Asako Kuhara, Naoko Ikehara, Ryoji Iwamoto, Shuji Nagata, Toshi Abe
    • Organizer
      Radiological Society of North America Annual Meeting (RSNA), 2016
    • Place of Presentation
      Chicago, United States
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of Tumor Invasiveness of Thymic Epithelial Tumors using Magnetic Resonance Imaging: Correlation with the World Health Organization Histologic Classification System Updated in 2015 and Masaoka-Koga Staging System2016

    • Author(s)
      Asako Kuhara, Kiminori Fujimoto, Akiko Sumi, Tomohiro Ebata, Shuji Nagata, Toshi Abe
    • Organizer
      Radiological Society of North America Annual Meeting (RSNA), 2016
    • Place of Presentation
      Chicago, United States
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2021-02-19  

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