Novel clinical application of dual-energy CT; liver fibrosis assessment utilizing equilibrium pase data
| Project/Area Number |
16K10301
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Radiation science
|
|---|
| Research Institution | Fukuoka University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
|
| Project Status |
Completed (Fiscal Year 2018)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
|---|
| Keywords | 肝線維化 / デュアルエナジーCT / ヨード-血液密度画像 / 細胞外液成分比率 / 血液プール / dual-energy CT / 平衡相 / ECV / CT / dual energy / 肝 / 線維化 |
|---|
| Outline of Final Research Achievements |
DECT of clinical patinets were retrospectively analyzed. ECV calculated from equilibrium phase were correlated to liver stiffness obtained by MR elastography, and pathological fibrosis grades. For ECV calculation, iodine-blood density images were obtained, in addition to conventional iodine-water density images. As for blood pool, IVC, not abdominal aorta, was additionally utilized. ECV obtained from iodine-blood density images using IVC as blood pool was best correlated eiter to liver stiffness or pathological fibrosis grades.
|
| Academic Significance and Societal Importance of the Research Achievements |
ルーチンの診断CTをDECTで撮像すれば、特別に新たな検査や侵襲を加える事無く、平衡相データを後解析することで肝の線維化が約8割の正診率で推定できることを示した。これは慢性肝疾患患者にとっては、肝癌のスクリーニングのために受けるCTのみで肝線維化の評価もできる、ということを意味し、大きな福音であると考えられる。
ただし、これには従来の手法を適用するだけでは十分な評価はできないことも判明したので、我々の考案したIVCを血液プールとしたヨード-血液密度画を用いることがポイントと言える。
|
Report
(4 results)
Research Products
(9 results)
