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Novel clinical application of dual-energy CT; liver fibrosis assessment utilizing equilibrium pase data

Research Project

Project/Area Number 16K10301
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionFukuoka University

Principal Investigator

Yoshimitsu Kengo  福岡大学, 医学部, 教授 (20274467)

Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肝線維化 / デュアルエナジーCT / ヨード-血液密度画像 / 細胞外液成分比率 / 血液プール / dual-energy CT / 平衡相 / ECV / CT / dual energy / 肝 / 線維化
Outline of Final Research Achievements

DECT of clinical patinets were retrospectively analyzed. ECV calculated from equilibrium phase were correlated to liver stiffness obtained by MR elastography, and pathological fibrosis grades. For ECV calculation, iodine-blood density images were obtained, in addition to conventional iodine-water density images. As for blood pool, IVC, not abdominal aorta, was additionally utilized. ECV obtained from iodine-blood density images using IVC as blood pool was best correlated eiter to liver stiffness or pathological fibrosis grades.

Academic Significance and Societal Importance of the Research Achievements

ルーチンの診断CTをDECTで撮像すれば、特別に新たな検査や侵襲を加える事無く、平衡相データを後解析することで肝の線維化が約8割の正診率で推定できることを示した。これは慢性肝疾患患者にとっては、肝癌のスクリーニングのために受けるCTのみで肝線維化の評価もできる、ということを意味し、大きな福音であると考えられる。
ただし、これには従来の手法を適用するだけでは十分な評価はできないことも判明したので、我々の考案したIVCを血液プールとしたヨード-血液密度画を用いることがポイントと言える。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2017

All Journal Article (1 results) Presentation (8 results) (of which Invited: 5 results)

  • [Journal Article] 多相性造影CTから得られる細胞外容積分画を用いた肝線維化の評価2018

    • Author(s)
      品川喜紳、吉満研吾
    • Journal Title

      肝クリニカルアップデート

      Volume: 4(2) Pages: 131-138

    • Related Report
      2018 Annual Research Report
  • [Presentation] 肝胆膵画像診断:最近の話題2019

    • Author(s)
      吉満研吾
    • Organizer
      肝胆膵臨床腫瘍カンファレンス
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 肝胆膵画像診断のトピックス2019

    • Author(s)
      吉満研吾
    • Organizer
      第551回広島レントゲンアーベント
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 押さえておきたい肝胆膵の画像診断2018

    • Author(s)
      吉満研吾
    • Organizer
      第87回筑豊画像研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 肝CTによる線維化診断:ECVによるアプローチ2018

    • Author(s)
      品川喜紳、吉満研吾、他
    • Organizer
      第24回肝血流動態機能イメジング研究会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 肝CTによる線維化診断:ECVによるアプローチ2018

    • Author(s)
      品川喜紳、吉満研吾、他
    • Organizer
      肝血流動態機能イメジング研究会
    • Related Report
      2017 Research-status Report
  • [Presentation] 腹部領域におけるCT画像診断の実際(Luncheon Seminar 19)2017

    • Author(s)
      吉満研吾
    • Organizer
      The 76th Annual Meeting of the Japan Radiological Society
    • Place of Presentation
      横浜
    • Year and Date
      2017-04-16
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Extracellular volume fraction calculated from the various data sets of the equilibrium phase of dual-energy CT as surrogate biomarkers for liver fibrosis: comparison with MR elastography2017

    • Author(s)
      武藤絵美、吉満研吾 他
    • Organizer
      The 76th Annual Meeting of the Japan Radiological Society
    • Place of Presentation
      横浜
    • Year and Date
      2017-04-15
    • Related Report
      2016 Research-status Report
  • [Presentation] Extracellular volume fraction calculated from the various data sets of the equilibrium phase of dual-energy CT as surrogate biomarkers for liver fibrosis: comparison with MR elastography2017

    • Author(s)
      Muto E, Yoshimitsu K, et al.
    • Organizer
      Annual meeting of Japanese Radiological Society (#045, Yokohama)
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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