Differential diagnosis of dementia based on image statistical analysis correlated with autopsy findings
| Project/Area Number |
16K10305
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tokyo Metropolitan Geriatric Hospital and Institute of Gerontology |
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Principal Investigator |
Tokumaru Aya M 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (60507391)
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| Research Collaborator |
MURAYAMA shigeo
SAITO yuko
ISHII kenji
SAKURAI keita
SHIMOJI keigo
KAMEYAMA masashi
IIJIMA ken
KANEMARU kazutomi
SENGOKU renpei
NISHINA yasushi
FIRUTA ko
YAMASHITA fumio
TOKUMARU asuka
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | Dementia / MRI / 嗜銀顆粒性認知症 / Dementia with grains / Alzheimer’s disease / 画像病理連関 / アルツハイマー病 / 高齢者タウオパチー / voxel based morphometry / 用手的体積測定法 / 認知症 / ＭＲＩ / 軽度認知機能障害 / 神経原線維変化型認知症 / レビー小体病 / 脳神経疾患 / 磁気共鳴画像 |
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| Outline of Final Research Achievements |
Senile tauopathy represents diseases in which abnormal deposition of tau protein in nerve cells and glial cells becomes predominant over Amyloid beta, and it includes AGD/DG , senile dementia of the neurofibrillary tangle type (tangle only dementia (SD-NFT))etc. AGD/DG and SD-NFT are present as the background pathology of MCI at almost the same rate as AD, establishment of the significance of an objective biomarker is desirable, for which development of a diagnostic technique using non-invasively applicable MR. The first objective of this study was to establish an imaging diagnostic technique for AGD/DG with pathologic evidence and clarify its significance as a biomarker of the diagnostic criteria through clinical application.
Based on experience of manual volume measurement, atrophic change of the ambient gyrus over the most medial surface of the entorhinal cortex was clearly noted in AGD/DG compared with those in AD and NC.
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| Academic Significance and Societal Importance of the Research Achievements |
超高齢化社会に突入した本邦での認知症対策は最重要課題である。認知症の一人一人が、社会の中で、より豊かな人生を生き抜くためには、まず正確な診断を得て早期の治療、適切な介護・看護、社会の中での受容に結び付けることが必要である。アルツハイマー病の治療薬開発が進む中、早期の臨床、画像所見が酷似する嗜銀顆粒性認知症や老年期神経原線維変化型認知症を、病初期に正確に鑑別することは喫緊の課題である。病因が異なるこれらの疾患では、効果のある薬剤は異なることが想定される。また嗜銀顆粒性認知症では、易怒性や性格変化等の前頭葉症状が前面に出やすいことも判ってきており、介護、看護の対応も大きく異なるためである。
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Report
(4 results)
Research Products
(50 results)
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[Journal Article] White Matter Hyperintensity in Elderly Patients with Diabetes Mellitus Is Associated with Cognitive Impairment, Functional Disability, and a High Glycoalbumin/Glycohemoglobin Ratio.2017
Author(s)
Tamura Y, Kimbara Y, Yamaoka T, Sato K, Tsuboi Y, Kodera R, Chiba Y, Mori S, Fujiwara Y, Tokumaru AM, Ito H, Sakurai T, Araki A.
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Journal Title
Front Aging Neurosci.
Volume: 9
Pages: 1-8
DOI
Related Report
Open Access
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[Journal Article] Dinosaur Tail Sign: A useful Spinal MRI Findings Indicative of Cerebrospinal Fluid Leakage2017
Author(s)
Sakurai K, Kanoto M, Nakagawa M, Shimohira M, Tokumaru AM, Kameyama M, Shimoji K, Morimoto S, Matsukawa N, Nishio M, Shibamoto Y.
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Journal Title
Headache
Volume: 印刷中
Issue: 6
Pages: 917-925
DOI
Related Report
Peer Reviewed
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[Journal Article] Beyond the midbrain atrophy: wide spectrum of structural MRI finding in cases of pathologically proven progressive supranuclear palsy2017
Author(s)
Sakurai K, Tokumaru AM, Shimoji K, Murayama S, Kanemaru K, Morimoto S, Aiba I, Nakagawa M, Ozawa Y, Shimohira M, Matsukawa N, Hashizume Y, Shibamoto Y.
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Journal Title
Neuroradiology
Volume: 印刷中
Issue: 5
Pages: 431-433
DOI
Related Report
Peer Reviewed
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[Journal Article] Volume of Interest Analysis of Spatially Normalized PRESTO Imaging to Differentiate between Parkinson Disease and Atypical Parkinsonian Syndrome2017
Author(s)
Sakurai K, Imabayashi E, Tokumaru AM, Ito K, Shimoji K, Nakagawa M, Ozawa Y, Shimohira M, Ogawa M, Morimoto S, Aiba I, Matsukawa N, Shibamoto Y.
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Journal Title
Magnetic Resonance in Medical Sciences
Volume: 16
Issue: 1
Pages: 16-22
DOI
NAID
ISSN
1347-3182, 1880-2206
Related Report
Peer Reviewed / Open Access
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[Presentation] 認知症精査における扁桃体腫大の臨床的意義-てんかん合併、治療効果との関連-2019
Author(s)
佐々木舞,德丸阿耶,村山繁雄,石井賢二,本山りえ,仁科泰史,金丸和人富,下地啓五,亀山征史,飯島健,玉本文彦
Organizer
第48回日本神経放射線学会
Related Report
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[Presentation] J-VAC studyにおける大脳皮質基底核変性症の画像所見-臨床、画像、遺伝子、生化学の多角的検討-2019
Author(s)
櫻井圭太,德丸阿耶,饗場郁子,若林孝一,齋藤祐子,小森隆司,吉田眞理,村山繁雄,長谷川成人,池内健,下畑享良,中島健二
Organizer
第48回日本神経放射線学会
Related Report
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