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From elderly person to children, evaluating development and aging from the viewpoint of functional MRI and physiological indicators

Research Project

Project/Area Number 16K10313
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionNagoya University

Principal Investigator

Nakane Toshiki  名古屋大学, 医学部附属病院, 助教 (60569789)

Co-Investigator(Kenkyū-buntansha) 長縄 慎二  名古屋大学, 医学系研究科, 教授 (50242863)
城所 博之  名古屋大学, 医学部附属病院, 助教 (20647466)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords脳機能画像 / MRI / 心拍変動 / 安静時脳機能 / 生理学的指標 / 脳 / 安静時 / 脳機能
Outline of Final Research Achievements

We measured, analyzed, and evaluated the relationship between the data obtained from physiological indices such as heart rate variability and the neural activity calculated from brain functional images. Regarding heartbeat, it is a factor that causes imaging artifacts in daily clinical image examination, but this time we analyzed brain functional images in relation to the aspect of the autonomic nervous system calculated from it. It was observed that resting brain activity formed networks known as the default mode network. The relationship with heart rate is currently under investifation.

Academic Significance and Societal Importance of the Research Achievements

人間の脳機能画像を身体に対する影響の少ないMRI装置を通して観察した。脳は何らかの作業もしていなくても活動しており、その活動の様子が年齢に伴い変化していくことや、その変化がMRI装置に付属のパルスオキシメーターから取得した脈拍から算出された人間の自律神経系のバランスの変化にどのように関連していくのかなど、人間の生理的な状態についての知見を深めるとともに通常の画像検査に付加的な意味を与えうる要素について検討した。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2020 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (2 results)

  • [Int'l Joint Research] SCCN(米国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Detection of IV-gadolinium Leakage from the Cortical Veins into the CSF Using MR Fingerprinting2020

    • Author(s)
      Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka, Hirokazu Kawaguchi, Katsuya Maruyama, Katsutoshi Murata, Gregor Korzdorfer, Josef Pfeuffer, Mathias Nittka, Michihiko Sone
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 19 Issue: 2 Pages: 141-146

    • DOI

      10.2463/mrms.mp.2019-0048

    • NAID

      130007839522

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Age Dependence of Gadolinium Leakage from the Cortical Veins into the Cerebrospinal Fluid Assessed with Whole Brain 3D-real Inversion Recovery MR Imaging2019

    • Author(s)
      Naganawa S, Nakane T, Kawai H, Taoka T.
    • Journal Title

      Magnetic Resonance in Medical Sciences

      Volume: 18 Issue: 2 Pages: 163-169

    • DOI

      10.2463/mrms.mp.2018-0053

    • NAID

      130007630075

    • ISSN
      1347-3182, 1880-2206
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Can low b value diffusion weighted imaging evaluate the character of cerebrospinal fluid dynamics?2019

    • Author(s)
      Taoka, T; Naganawa, S; Kawai, H; Nakane, T; Murata, K
    • Journal Title

      JAPANESE JOURNAL OF RADIOLOGY

      Volume: 37 Issue: 2 Pages: 135-144

    • DOI

      10.1007/s11604-018-0790-8

    • NAID

      210000164484

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] テクスチャー解析を用いたMP2RAGEでの視床内部構造の評価2018

    • Author(s)
      中根俊樹、田岡俊昭、川井恒、加藤裕、桜井康雄、丸山克也、長縄慎二
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] MP2RAGEを用いた視床内部構造の描出2017

    • Author(s)
      中根俊樹、田岡俊昭、川井恒、加藤裕、桜井康雄、丸山克也、長縄慎二
    • Organizer
      日本磁気共鳴医学会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2022-02-16  

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