From elderly person to children, evaluating development and aging from the viewpoint of functional MRI and physiological indicators

• Project/Area Number: 16K10313
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nagoya University
• Principal Investigator: Nakane Toshiki 名古屋大学, 医学部附属病院, 助教 (60569789)
• Co-Investigator(Kenkyū-buntansha): 長縄 慎二 名古屋大学, 医学系研究科, 教授 (50242863) ; 城所 博之 名古屋大学, 医学部附属病院, 助教 (20647466)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 脳機能画像 / MRI / 心拍変動 / 安静時脳機能 / 生理学的指標 / 脳 / 安静時 / 脳機能

Outline of Final Research Achievements

We measured, analyzed, and evaluated the relationship between the data obtained from physiological indices such as heart rate variability and the neural activity calculated from brain functional images. Regarding heartbeat, it is a factor that causes imaging artifacts in daily clinical image examination, but this time we analyzed brain functional images in relation to the aspect of the autonomic nervous system calculated from it. It was observed that resting brain activity formed networks known as the default mode network. The relationship with heart rate is currently under investifation.

Academic Significance and Societal Importance of the Research Achievements

人間の脳機能画像を身体に対する影響の少ないMRI装置を通して観察した。脳は何らかの作業もしていなくても活動しており、その活動の様子が年齢に伴い変化していくことや、その変化がMRI装置に付属のパルスオキシメーターから取得した脈拍から算出された人間の自律神経系のバランスの変化にどのように関連していくのかなど、人間の生理的な状態についての知見を深めるとともに通常の画像検査に付加的な意味を与えうる要素について検討した。

Research Products

• [Int'l Joint Research] SCCN(米国)
• [Journal Article] Detection of IV-gadolinium Leakage from the Cortical Veins into the CSF Using MR Fingerprinting (2020)
  • Author(s): Shinji Naganawa, Toshiki Nakane, Hisashi Kawai, Toshiaki Taoka, Hirokazu Kawaguchi, Katsuya Maruyama, Katsutoshi Murata, Gregor Korzdorfer, Josef Pfeuffer, Mathias Nittka, Michihiko Sone
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 19 Issue: 2 Pages: 141-146
  • DOI: 10.2463/mrms.mp.2019-0048
  • NAID: 130007839522
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Age Dependence of Gadolinium Leakage from the Cortical Veins into the Cerebrospinal Fluid Assessed with Whole Brain 3D-real Inversion Recovery MR Imaging (2019)
  • Author(s): Naganawa S, Nakane T, Kawai H, Taoka T.
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 18 Issue: 2 Pages: 163-169
  • DOI: 10.2463/mrms.mp.2018-0053
  • NAID: 130007630075
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Open Access
• [Journal Article] Can low b value diffusion weighted imaging evaluate the character of cerebrospinal fluid dynamics? (2019)
  • Author(s): Taoka, T; Naganawa, S; Kawai, H; Nakane, T; Murata, K
  • Journal Title: JAPANESE JOURNAL OF RADIOLOGY Volume: 37 Issue: 2 Pages: 135-144
  • DOI: 10.1007/s11604-018-0790-8
  • NAID: 210000164484
  • Peer Reviewed / Open Access
• [Presentation] テクスチャー解析を用いたMP2RAGEでの視床内部構造の評価 (2018)
  • Author(s): 中根俊樹、田岡俊昭、川井恒、加藤裕、桜井康雄、丸山克也、長縄慎二
  • Organizer: 第46回日本磁気共鳴医学会大会
• [Presentation] MP2RAGEを用いた視床内部構造の描出 (2017)
  • Author(s): 中根俊樹、田岡俊昭、川井恒、加藤裕、桜井康雄、丸山克也、長縄慎二
  • Organizer: 日本磁気共鳴医学会