Pseudo-Continuous Arterial Spin Labeling: Clinical Application and Usefulness for Head and Neck Tumors

• Project/Area Number: 16K10314
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Mie University
• Principal Investigator: Umino Maki 三重大学, 医学部附属病院, 助教 (30649059)
• Co-Investigator(Kenkyū-buntansha): 前田 正幸 三重大学, 医学系研究科, 寄附講座教授 (70219278) ; 野本 由人 三重大学, 医学系研究科, 寄附講座教授 (10252363) ; 中山 良平 立命館大学, 理工学部, 教授 (20402688)
• Project Period (FY): 2016-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 頭頚部腫瘍 / 機能的MRI撮影法 / 画像解析 / arterial spin labeling / 頭頸部腫瘍 / 癌 / 放射線 / 解析・評価

Outline of Final Research Achievements

Pseudocontinuous arterial spin labeling (pCASL) imaging enables noninvasive quantification of tumor blood flow in the head and neck. The purpose of this study was to compare echo-planar (EP) and turbo spin-echo (TSE) sequences of pCASL, to demonstrate the clinical applications and usefulness of this method in the diagnosis of particular diseases via both tumor blood flow (TBF) quantification and the apparent diffusion coefficient (ADC) obtained by diffusion-weighted imaging (DWI), and to demonstrate changes in TBF after chemoradiation treatments.
TSE pCASL showed less image torsion and higher lesion conspicuity than EP pCASL. Combination of TSE pCASL and ADC enabled to differentiate benign parotid tumors from malignant parotid tumors. TBF changes were observed in head and neck squamous cell carcinomas in response to chemoradiation at an early stage. This study showed that the combination of pCASL and ADC is a promising tool for head and neck tumors.

Academic Significance and Societal Importance of the Research Achievements

頭頚部腫瘍を評価する非侵襲的な診断方法としてMRIを活用することは理にかなっている。本研究で開発された新しい血流と拡散の撮像方法を用いて得たデータを同時に解析できるソフトウェアは頭頚部腫瘍の良悪性の鑑別および質的診断、頭頚部悪性腫瘍の放射線治療後の変化において優れた診断精度を示した。頭頚部腫瘍の良悪性鑑別および質的診断、早期治療効果を非侵襲的に診断する本研究成果は、臨床への大きな貢献につながる。

Research Products

• [Journal Article] Cerebral Microbleeds With Atrial Fibrillation After Ablation Therapy (2022)
  • Author(s): Hirata Yoshinori、Kato Natsuko、Muraga Kanako、Shindo Akihiro、Nakamura Naoko、Matsuura Keita、Ii Yuichiro、Shiga Mariko、Tabei Ken-ichi、Satoh Masayuki、Fukuma Tomoyuki、Kagawa Yoshihiko、Fujita Satoshi、Kogue Ryota、Umino Maki、Maeda Masayuki、Sakuma Hajime、Dohi Kaoru、Tomimoto Hidekazu
  • Journal Title: Frontiers in Cellular Neuroscience Volume: 16 Pages: 818288-818288
  • DOI: 10.3389/fncel.2022.818288
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Neuromelanin-sensitive magnetic resonance imaging in disease differentiation for parkinsonism or neurodegenerative disease affecting the basal ganglia (2021)
  • Author(s): Matsuura Keita、Ii Yuichiro、Maeda Masayuki、Tabei Ken-ichi、Satoh Masayuki、Umino Maki、Miyashita Koichi、Ishikawa Hidehiro、Shindo Akihiro、Tomimoto Hidekazu
  • Journal Title: Parkinsonism & Related Disorders Volume: 87 Pages: 75-81
  • DOI: 10.1016/j.parkreldis.2021.05.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Evaluation of cortical superficial siderosis in patients with cognitive dysfunction using 3D FLAIR and 3D DIR (2021)
  • Author(s): Umino Maki、Maeda Masayuki、Kogue Ryota、Nakamura Satoshi、Ii Yuichiro、Tomimoto Hidekazu、Sakuma Hajime
  • Journal Title: European Radiology Volume: 31 Issue: 9 Pages: 6411-6418
  • DOI: 10.1007/s00330-021-07751-x
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Brain magnetic resonance imaging and cognitive alterations after ablation in patients with atrial fibrillation (2021)
  • Author(s): Kato Natsuko、Muraga Kanako、Hirata Yoshinori、Shindo Akihiro、Matsuura Keita、Ii Yuichiro、Shiga Mariko、Tabei Ken-ichi、Satoh Masayuki、Fujita Satoshi、Fukuma Tomoyuki、Kagawa Yoshihiko、Fujii Eitaro、Umino Maki、Maeda Masayuki、Sakuma Hajime、Ito Masaaki、Tomimoto Hidekazu
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 18995-18995
  • DOI: 10.1038/s41598-021-98484-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hemangioblastoma of the Cerebellopontine Angle Evaluated with Pseudocontinuous Arterial Spin Labeling (2021)
  • Author(s): Kishi Seiya、Maeda Masayuki、Kogue Ryota、Umino Maki、Matsubara Toshio、Sakuma Hajime
  • Journal Title: Magnetic Resonance in Medical Sciences Volume: 20 Issue: 1 Pages: 18-19
  • DOI: 10.2463/mrms.ici.2020-0011
  • NAID: 130007993613
  • ISSN: 1347-3182, 1880-2206
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Evaluation of Intradural Ecchordosis Physaliphora With Three-Dimensional Fluid-Attenuated Inversion Recovery (2020)
  • Author(s): Kogue Ryota、Maeda Masayuki、Umino Maki、Kishi Seiya、Tanaka Fumine、Tsuchiya Kazuhiro、Sakuma Hajime
  • Journal Title: Journal of Computer Assisted Tomography Volume: 44 Issue: 5 Pages: 699-703
  • DOI: 10.1097/rct.0000000000001027
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A Case of Suspected Metallic Embolism after Carotid Artery Stenting (2020)
  • Author(s): Kishimoto Tomoyuki、Yasuda Ryuta、Umino Maki、Goto Fuki、Toma Naoki、Maeda Masayuki、Suzuki Hidenori
  • Journal Title: NMC Case Report Journal Volume: 7 Issue: 4 Pages: 229-231
  • DOI: 10.2176/nmccrj.cr.2020-0027
  • NAID: 130007921688
  • ISSN: 2188-4226
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hypertensive Arteriopathy and Cerebral Amyloid Angiopathy in Patients with Cognitive Decline and Mixed Cerebral Microbleeds (2020)
  • Author(s): Ii Yuichiro、Ishikawa Hidehiro、Matsuyama Hirofumi、Shindo Akihiro、Matsuura Keita、Yoshimaru Kimiko、Satoh Masayuki、Taniguchi Akira、Matsuda Kana、Umino Maki、Maeda Masayuki、Tomimoto Hidekazu
  • Journal Title: Journal of Alzheimer's Disease Volume: 78 Issue: 4 Pages: 1765-1774
  • DOI: 10.3233/jad-200992
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between cortical microinfarcts and total small vessel disease burden in cerebral amyloid angiopathy on 3‐Tesla magnetic resonance imaging (2020)
  • Author(s): Ii Yuichiro、Ishikawa Hidehiro、Shindo Akihiro、Matsuyama Hirofumi、Matsuura Keita、Matsuda Kana、Yoshimaru Kimiko、Satoh Masayuki、Kogue Ryota、Umino Maki、Maeda Masayuki、Tomimoto Hidekazu
  • Journal Title: European Journal of Neurology Volume: 28 Issue: 3 Pages: 794-799
  • DOI: 10.1111/ene.14610
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cortical microinfarcts in patients with multiple lobar microbleeds on 3?T MRI (2019)
  • Author(s): Ii Yuichiro、Maeda Masayuki、Ishikawa Hidehiro、Ito Ai、Matsuo Ko、Umino Maki、Shindo Akihiro、Kida Hirotaka、Satoh Masayuki、Niwa Atsushi、Taniguchi Akira、Tomimoto Hidekazu
  • Journal Title: Journal of Neurology Volume: 266 Issue: 8 Pages: 1887-1896
  • DOI: 10.1007/s00415-019-09350-9
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Vertebral artery dissection associated with familial Mediterranean fever and Beh?et's disease (2019)
  • Author(s): Ishikawa Hidehiro、Shindo Akihiro、Ii Yuichiro、Sakano Shoko、Asahi Masaru、Matsuura Keita、Kishida Dai、Umino Maki、Maeda Masayuki、Tomimoto Hidekazu
  • Journal Title: Annals of Clinical and Translational Neurology Volume: 6 Issue: 5 Pages: 974-978
  • DOI: 10.1002/acn3.773
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] A case of a rosette-forming glioneuronal tumor arising from the pons with disappearance of contrast enhancement (2019)
  • Author(s): Tanaka Fumine、Matsukawa Megumi、Kogue Ryota、Umino Maki、Maeda Masayuki、Uchida Katsunori、Imai Hiroshi、Matsubara Toshio、Sakuma Hajime
  • Journal Title: Radiology Case Reports Volume: 14 Issue: 8 Pages: 899-902
  • DOI: 10.1016/j.radcr.2019.05.011
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Microbleeds after Carotid Artery Stenting: Small Embolism May Induce Cerebral Microbleeds (2019)
  • Author(s): Ogawa Ito Ai、Shindo Akihiro、Ii Yuichiro、Matsuura Keita、Tabei Ken-ichi、Maeda Masayuki、Umino Maki、Suzuki Yume、Shiba Masato、Toma Naoki、Suzuki Hidenori、Tomimoto Hidekazu
  • Journal Title: Cerebrovascular Diseases Extra Volume: 9 Issue: 2 Pages: 57-65
  • DOI: 10.1159/000500112
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Evaluation of a high-signal lesion posterior to the intracranial vertebral artery using 3D balanced fast-field echo imaging. (2019)
  • Author(s): Kogue R, Maeda M, Umino M, Tsuchiya K, Sakuma H.
  • Journal Title: Neuroradiology. Volume: 61 Issue: 10 Pages: 1199-1202
  • DOI: 10.1007/s00234-019-02270-5
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Small high-signal lesions posterior to the intracranial vertebral artery incidentally identified by 3D FLAIR: retrospective study of 127 patients. (2018)
  • Author(s): Kogue R, Maeda M, Umino M, Tsuchiya K, Sakuma H.
  • Journal Title: Neuroradiology. Volume: 60 Issue: 6 Pages: 591-597
  • DOI: 10.1007/s00234-018-2027-z
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 3D double inversion recovery MR imaging: Clinical applications and usefulness in a wide spectrum of central nervous system diseases. (2018)
  • Author(s): Umino M, Maeda M, Ii Y, Tomimoto H, Sakuma H.
  • Journal Title: J Neuroradiol. Volume: 46 Issue: 2 Pages: 107-116
  • DOI: 10.1016/j.neurad.2018.06.002
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Background and distribution of lobar microbleeds in cognitive dysfunction. (2017)
  • Author(s): Matsuyama H, Ii Y, Maeda M, Umino M, Ueda Y, Tabei KI, Kida H, Satoh M, Shindo A, Taniguchi A, Takahashi R, Tomimoto H1
  • Journal Title: Brain Behav. Volume: 7 Issue: 11
  • DOI: 10.1002/brb3.856
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Ipilimumab-induced hypophysitis involving the optic tracts and tuber cinereum evaluated using 3D fluid-attenuated inversion recovery. (2017)
  • Author(s): Tanaka F, Kogue R, Maeda M, Umino M, Nakai Y, Takeshita A, Sakuma H.
  • Journal Title: Radiol Case Rep. Volume: 13 Issue: 1 Pages: 261-264
  • DOI: 10.1016/j.radcr.2017.11.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Suspected Metallic Embolism following Endovascular Treatment of Intracranial Aneurysms. (2016)
  • Author(s): Yasuda R, Maeda M, Umino M, Nakatsuka Y, Umeda Y, Toma N, Sakaida H, Suzuki H.
  • Journal Title: AJNR Am J Neuroradiol. Volume: 37 Issue: 9 Pages: 1696-1699
  • DOI: 10.3174/ajnr.a4804
  • Peer Reviewed / Int'l Joint Research
• [Presentation] Pseudo-Continuous Arterial Spin Labeling: Clinical Application and Usefulness for Head and Neck Entities (2018)
  • Author(s): Umino M, Maeda M, Inoue K, Nakayama R, Nomoto Y, Sakuma H
  • Organizer: 第77回日本医学放射線学会総会
• [Presentation] Pseudocontinuous Arterial Spin Labeling: Clinical Applications and Usefulness in the Evaluation of Head and Neck Lesions (2018)
  • Author(s): Umino M, Nakayama R, Inoue K, Kogue R, Maeda M, Sakuma H.
  • Organizer: ASNR 56th Annual Meeting
  • Int'l Joint Research
• [Presentation] Pseudocontinuous Arterial Spin Labeling: Clinical Applications and Usefulness in Head and Neck Entities (2018)
  • Author(s): Umino M, Maeda M, Inoue K, Nakayama R, Nomoto Y, Sakuma H.
  • Organizer: 104th Scientific Assembly and Annual Meeting of the Radiological Society of North America
  • Int'l Joint Research
• [Presentation] Pseudocontinuous arterial spin labeling: Clinical applications and usefulness in head and neck entities (2018)
  • Author(s): Umino M, Maeda M, Inoue K, Nakayama R, Nomoto Y, Sakuma H
  • Organizer: European Congress of Radiology 2018
  • Int'l Joint Research
• [Presentation] Clinical applications and usefulness of pseudocontinuous arterial spin labeling in head and neck entities (2018)
  • Author(s): Maeda M, Umino M, Nakayama R, Inoue K, Kogue R, Sakuma H
  • Organizer: XXI Symposium Neuroradiologicum
  • Int'l Joint Research
• [Presentation] Measurement of blood flow in normal parotid glands using pseudo-continuous arterial spin labeling (2017)
  • Author(s): Inoue K, Umino M, Nakayama R, Takase S, Yamahata T, Obara M, Maeda M, Sakuma H
  • Organizer: The International Society for Magnetic Resonance in Medicine 25th Annual Meeting
  • Int'l Joint Research
• [Presentation] Measurement of blood flow of normal parotid glands using pseudo-continuous arterial spin labeling (2016)
  • Author(s): Inoue k, Isoshima S, Takase S, Yamahata T, Umino M, Maeda m
  • Organizer: 第44回日本磁気共鳴医学会大会
  • Place of Presentation: 大宮ソニックシティ （埼玉県・さいたま市）
  • Year and Date: 2016-09-09
• [Book] 画像診断２０１８年３月増刊号（Ｖｏｌ．３８Ｎｏ．４） 頭部の鑑別診断のポイント (2018)
  • Author(s): 青木茂樹、大場洋
  • Total Pages: 244
  • Publisher: 学研メディカル秀潤社
  • ISBN: 9784780909586