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Development of the method for cervical carotid plaque volume using high-resolution 3D vessel wall MRI

Research Project

Project/Area Number 16K10315
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionMie University

Principal Investigator

Maeda Masayuki  三重大学, 医学系研究科, 教授 (70219278)

Co-Investigator(Kenkyū-buntansha) 中山 良平  立命館大学, 理工学部, 准教授 (20402688)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
KeywordsMRI / 頸部頸動脈狭窄 / 不安定プラーク / ソフトウェア / 容積計測 / 頸部頸動脈 / プラーク / 3次元MRI / 血管壁MRI / 頸動脈プラーク / 頸動脈 / 体積 / ソフトウエア / 脳神経疾患 / 臨床
Outline of Final Research Achievements

In cervical carotid artery stenosis, plaque evaluation is considered to be important in relation to the incidence of cerebral infarction.The purpose of this study was to establish the quantitative method for the high signal plaque volume of cervical carotid arteries using high-resolution 3D vessel wall MRI and semi-automated software for MRI segmentation and volume quantification of high signal plaques.We investigated whether this method shows significant diagnostic accuracy for the assessment of high signal plaques in patients with cervical carotid artery stenosis.This study showed that the method enabled to accurately measure high signal plaque volume.

Academic Significance and Societal Importance of the Research Achievements

世界的に見て日本はMRIの保有率が高く、また検査数も多い。したがって、頸部頸動脈狭窄症を評価する診断方法としてMRIの持つ診断ポテンシャルを活用することは理にかなっている。本研究により開発された高分解能3次元血管壁MRIとプラーク容積計測ソフトウェアは、不安定プラークとされる高信号プラークの容積評価において優れた診断精度を示した。
臨床的に脳梗塞と強い関連があると考えられている高信号プラークの容積を簡便で正確に計測できるメリットは、内科的介入による治療効果の判定の際に有用であると考えられた。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (37 results)

All 2020 2019 2018 2017 2016

All Journal Article (14 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 14 results,  Open Access: 7 results) Presentation (17 results) (of which Int'l Joint Research: 8 results,  Invited: 3 results) Book (6 results)

  • [Journal Article] Cortical Microinfarcts Detected by 3-Tesla Magnetic Resonance Imaging2020

    • Author(s)
      Ishikawa Hidehiro、Ii Yuichiro、Shindo Akihiro、Tabei Ken-ichi、Umino Maki、Ito Ai Ogawa、Matsuura Keita、Taniguchi Akira、Matsuyama Hirofumi、Niwa Atsushi、Ogura Toru、Yoshimaru Kimiko、Satoh Masayuki、Maeda Masayuki、Tomimoto Hidekazu
    • Journal Title

      Stroke

      Volume: 51 Issue: 3 Pages: 1010-1013

    • DOI

      10.1161/strokeaha.119.028202

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Low Pulvinar Intensity in Susceptibility-Weighted Imaging May Suggest Cognitive Worsening After Deep Brain Stimulation Therapy in Patients With Parkinson's Disease2019

    • Author(s)
      Matsuura Keita、Maeda Masayuki、Satoh Masayuki、Tabei Ken-ichi、Araki Tomohiro、Umino Maki、Kajikawa Hiroyuki、Nakamura Naoko、Tomimoto Hidekazu
    • Journal Title

      Frontiers in Neurology

      Volume: 10 Pages: 1-8

    • DOI

      10.3389/fneur.2019.01158

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Microbleeds after Carotid Artery Stenting: Small Embolism May Induce Cerebral Microbleeds2019

    • Author(s)
      Ogawa Ito Ai、Shindo Akihiro、Ii Yuichiro、Matsuura Keita、Tabei Ken-ichi、Maeda Masayuki、Umino Maki、Suzuki Yume、Shiba Masato、Toma Naoki、Suzuki Hidenori、Tomimoto Hidekazu
    • Journal Title

      Cerebrovascular Diseases Extra

      Volume: 9 Issue: 2 Pages: 57-65

    • DOI

      10.1159/000500112

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cortical microinfarcts in patients with multiple lobar microbleeds on 3?T MRI2019

    • Author(s)
      Ii Yuichiro、Maeda Masayuki、Ishikawa Hidehiro、Ito Ai、Matsuo Ko、Umino Maki、Shindo Akihiro、Kida Hirotaka、Satoh Masayuki、Niwa Atsushi、Taniguchi Akira、Tomimoto Hidekazu
    • Journal Title

      Journal of Neurology

      Volume: 266 Issue: 8 Pages: 1887-1896

    • DOI

      10.1007/s00415-019-09350-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evaluation of a high-signal lesion posterior to the intracranial vertebral artery using 3D balanced fast-field echo imaging.2019

    • Author(s)
      Kogue R, Maeda M, Umino M, Tsuchiya K, Sakuma H.
    • Journal Title

      Neuroradiology.

      Volume: 61 Issue: 10 Pages: 1199-1202

    • DOI

      10.1007/s00234-019-02270-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Small high-signal lesions posterior to the intracranial vertebral artery incidentally identified by 3D FLAIR: retrospective study of 127 patients.2018

    • Author(s)
      Kogue R, Maeda M, Umino M, Tsuchiya K, Sakuma H.
    • Journal Title

      Neuroradiology.

      Volume: 60 Issue: 6 Pages: 591-597

    • DOI

      10.1007/s00234-018-2027-z

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 3D double inversion recovery MR imaging: Clinical applications and usefulness in a wide spectrum of central nervous system diseases.2018

    • Author(s)
      Umino M, Maeda M, Ii Y, Tomimoto H, Sakuma H.
    • Journal Title

      J Neuroradiol.

      Volume: 46 Issue: 2 Pages: 107-116

    • DOI

      10.1016/j.neurad.2018.06.002

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical significance of cortical lesions in patients with multiple sclerosis: A neuropsychological and neuroimaging study.2018

    • Author(s)
      Matsushita F, Kida H, Tabei KI, Nakano C, Matsuura K, Ii Y, Sasaki R, Taniguchi A, Narita Y, Maeda M, Satoh M, Tomimoto H.
    • Journal Title

      Brain Behav

      Volume: 8 Issue: 3

    • DOI

      10.1002/brb3.934

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Revisiting current golden rules in managing acute ischemic stroke: evaluation of new strategies to further improve treatment selection and outcome2017

    • Author(s)
      William TC Yuh, Matthew David Alexander, Toshihiro Ueda, Masayuki Maeda, Toshiaki Taoka, Kei Yamada, Norman J Beauchamp
    • Journal Title

      American Journal of Roentgenology

      Volume: 208 Issue: 1 Pages: 32-41

    • DOI

      10.2214/ajr.16.16557

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A case of 55-year-old man with first-ever generalized seizure diagnosed with Sturge-Weber syndrome type III by characteristic MRI findings2017

    • Author(s)
      Ishikawa H, Ii Y, Niwa A, Matsuura K, Maeda M, Tomimoto H.
    • Journal Title

      Rinsho Shinkeigaku

      Volume: 57 Issue: 5 Pages: 214-219

    • DOI

      10.5692/clinicalneurol.cn-001006

    • NAID

      130005681746

    • ISSN
      0009-918X, 1882-0654
    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparative Analysis of Cortical Microinfarcts and Microbleeds using 3.0-Tesla Postmortem Magnetic Resonance Images and Histopathology.2017

    • Author(s)
      Niwa A, Ii Y, Shindo A, Matsuo K, Ishikawa H, Taniguchi A, Takase S, Maeda M, Sakuma H, Akatsu H, Hashizume Y, Tomimoto H.
    • Journal Title

      J Alzheimers Dis.

      Volume: 59 Issue: 3 Pages: 951-959

    • DOI

      10.3233/jad-161242

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Background and distribution of lobar microbleeds in cognitive dysfunction.2017

    • Author(s)
      Matsuyama H, Ii Y, Maeda M, Umino M, Ueda Y, Tabei KI, Kida H, Satoh M, Shindo A, Taniguchi A, Takahashi R, Tomimoto H1
    • Journal Title

      Brain Behav.

      Volume: 7 Issue: 11

    • DOI

      10.1002/brb3.856

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ipilimumab-induced hypophysitis involving the optic tracts and tuber cinereum evaluated using 3D fluid-attenuated inversion recovery.2017

    • Author(s)
      Tanaka F, Kogue R, Maeda M, Umino M, Nakai Y, Takeshita A, Sakuma H.
    • Journal Title

      Radiol Case Rep.

      Volume: 13 Issue: 1 Pages: 261-264

    • DOI

      10.1016/j.radcr.2017.11.007

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cervical carotid plaque evaluation using 3D T1-weighted black-blood magnetic resonance imaging: Comparison of turbo field-echo and turbo spin-echo sequences.2016

    • Author(s)
      Inoue K, Maeda M, Umino M, Takase S, Yamahata T, Sakuma H.
    • Journal Title

      Eur J Radiol.

      Volume: 85 Issue: 5 Pages: 1035-9

    • DOI

      10.1016/j.ejrad.2016.03.007

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 心房細動アブレーション後に生じる皮質/皮質下微小梗塞の前方視的研究2020

    • Author(s)
      小久江良太, 前田正幸, 海野真記, 加藤奈津子, 新堂晃大, 伊井裕一郎, 藤井英太郎, 伊藤正明, 冨本秀和, 佐久間肇
    • Organizer
      日本神経放射線学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 定量的磁化率マッピングにおけるCompressed SENSEのDenoising強度による比較検討.2019

    • Author(s)
      磯嶋志保, 井上勝博, 高瀬伸一, 山畑経博, 海野真記, 小久江良太, 前田正幸.
    • Organizer
      日本磁気共鳴医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 3D FLAIRによる泡状外脊索症の評価.2019

    • Author(s)
      小久江良太, 前田正幸, 海野真記, 佐久間肇, 土屋一洋.
    • Organizer
      日本神経放射線学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Small high-signal lesion posterior to the intracranial vertebral artery incidentally identified by 3D FLAIR: Analysis of the relationship to the spinal accessory nerve by 3D balanced fast field echo MR imaging2019

    • Author(s)
      Ryota Kogue, Masayuki Maeda, Maki Umino, Kazuhiro Tsuchiya, Hajime Sakuma
    • Organizer
      Miyazaki Phoenix Neuroradiology Meeting
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 3D FLAIRによる泡状外脊索症の評価2019

    • Author(s)
      小久江良太、前田正幸、海野真記、佐久間肇、土屋一洋
    • Organizer
      第48回日本神経放射線学会
    • Related Report
      2018 Research-status Report
  • [Presentation] Pseudo-Continuous Arterial Spin Labeling: Clinical Application and Usefulness for Head and Neck Entities2018

    • Author(s)
      Umino M, Maeda M, Inoue K, Nakayama R, Nomoto Y, Sakuma H.
    • Organizer
      第77回日本医学放射線学会総会
    • Related Report
      2018 Research-status Report
  • [Presentation] Comparison of compressed SENSE and SENSE in quantitative susceptibility mapping (QSM)2018

    • Author(s)
      Isoshima S, Inoue K, Yamashita T, Takase S, Suwa T, Obara M, Umino M, Maeda M.
    • Organizer
      第46回日本磁気共鳴医学会大会
    • Related Report
      2018 Research-status Report
  • [Presentation] Pseudocontinuous Arterial Spin Labeling: Clinical Applications and Usefulness in the Evaluation of Head and Neck Lesions2018

    • Author(s)
      Umino M, Nakayama R, Inoue K, Kogue R, Maeda M, Sakuma H.
    • Organizer
      56th Annual Meeting of American Society of Neuroradiology (ASNR)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Small high signal lesions adjacent to the intracranial vertebral artery incidentally identified by 3D FLAIR: analysis of 150 patients2018

    • Author(s)
      Kogue R, Maeda M, Umino M, Tsuchiya K, Sakuma H.
    • Organizer
      56th Annual Meeting of American Society of Neuroradiology (ASNR)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Pseudocontinuous Arterial Spin Labeling: Clinical Applications and Usefulness in Head and Neck Entities2018

    • Author(s)
      Umino M, Maeda M, Inoue K, Nakayama R, Nomoto Y, Sakuma H.
    • Organizer
      104th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Small high-signal lesion posterior to the intracranial vertebral artery incidentally identified by 3D FLAIR: Analysis of the relationship to the spinal accessory nerve by 3D balanced fast field echo MR imaging2018

    • Author(s)
      Kogue R, Maeda M, Umino M, Tsuchiya K, Sakuma H.
    • Organizer
      104th Scientific Assembly and Annual Meeting of the Radiological Society of North America (RSNA)
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research
  • [Presentation] Cervical carotid-plaque volume using 3D T1 black-blood MRI: comparison between manual and automated measurements2018

    • Author(s)
      Masayuki Maeda, Shiho Isoshima, Katsuhiro Inoue, Ryohei Nakayama, Maki Umino, Hajime Sakuma
    • Organizer
      The World Congress of Neuroradiology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of cervical carotid-plaque volume using 3D T1 black-blood MRI: comparison between manual and automated measurements2017

    • Author(s)
      Shiho Isoshima, Masayuki Maeda, Katsuhiro Inoue, Ryohei Nakayama, Shinichi Takase, Tsunehiro Yamahata, Hajime Sakuma
    • Organizer
      ISMRM 25th Annual Meeting & Exhibition
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Evaluation of longitudinal high signal plaque volumes of cervical carotid artery using 3D T1-weighted black-blood imaging: comparison of manual and automated software measurements2017

    • Author(s)
      Katsuhiro Inoue, Shiho Isoshima, Ryohei Nakayama , Maki Umino, Shinichi Takase, Tsunehiro Yamahata, Masayuki Maeda
    • Organizer
      日本磁気共鳴学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Evaluation of cervical carotid plaque volume using 3D T1-VISTA: Comparison of manual measurement and automatic measurement by the in-house software2016

    • Author(s)
      Isoshima S, Inoue K, Nakayama R, Takase S, Yamahata T, Maeda M
    • Organizer
      日本磁気共鳴医学会
    • Place of Presentation
      大宮ソニック(埼玉県・さいたま市)
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
  • [Presentation] Clinical application of 3D T1-weighted black-blood MRI in head and neck arterial lesions2016

    • Author(s)
      Maeda M
    • Organizer
      American Society of Neuroradiology
    • Place of Presentation
      ワシントン DC (米国)
    • Year and Date
      2016-05-21
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Clinical applications of 3D T1-weighted black-blood MRI in head and neck arterial lesions2016

    • Author(s)
      Maeda M
    • Organizer
      Japan-Korea-Taiwan Workshop Frontiers in Neuroimaging
    • Place of Presentation
      ソウル(韓国)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Book] 画像診断 2020年1月号 Vol.40 No.12020

    • Author(s)
      田中史根、前田正幸、松原年生
    • Total Pages
      120
    • Publisher
      学研メディカル秀潤社
    • ISBN
      9784780905243
    • Related Report
      2019 Annual Research Report
  • [Book] 頭蓋・顔面病変の画像診断 : 誰も教えてくれなかった!2019

    • Author(s)
      前田正幸
    • Total Pages
      164
    • Publisher
      メジカルビュー社
    • ISBN
      9784758316071
    • Related Report
      2019 Annual Research Report
  • [Book] 臨床画像 2019年11月号 Vol.35 No.112019

    • Author(s)
      前田正幸
    • Total Pages
      136
    • Publisher
      メジカルビュー社
    • Related Report
      2019 Annual Research Report
  • [Book] 画像診断2018年3月増刊号(Vol.38No.4) 頭部の鑑別診断のポイント2018

    • Author(s)
      前田正幸
    • Total Pages
      244
    • Publisher
      学研メディカル秀潤社
    • ISBN
      9784780909586
    • Related Report
      2017 Research-status Report
  • [Book] 知っておきたい顎・歯・口腔の画像診断2017

    • Author(s)
      前田正幸
    • Total Pages
      368
    • Publisher
      学研メディカル秀潤社
    • ISBN
      9784780909395
    • Related Report
      2017 Research-status Report
  • [Book] 下垂体の画像診断2017

    • Author(s)
      前田正幸
    • Total Pages
      243
    • Publisher
      Medical View
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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