| Project/Area Number |
16K10316
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
渡邉 尚武 滋賀医科大学, 医学部, 客員助教 (60570364)
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| Project Period (FY) |
2016-10-21 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 動脈硬化 / 高脂血症剤 / MRI / 病理 / 高脂血症 / ウサギ / 抗コレステロール血症 / WHHL-MIウサギ / マクロファージ / 造影 / RAM11 / 画像 / 動物 / WHHL / BLADE/PROPELLER / 医療 |
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| Outline of Final Research Achievements |
Results: The proportion of collagen fiber in vascular walls of the Probucol diet (+) group of rabbits was significantly less compared to the Probucol diet (-) group. The correlation coefficient between FS-T2WI SWR and the proportion of elastic fiber to collagen fiber in the vascular wall (PEF/CF) was 0.48. The correlation coefficient between FS-T1WI SWR and (PEF/CF) was 0.31, Gd-enhanced T1WI SWR and (PEF/CF) was -0.34.
Conclusion: We think that Probucol reduces collagen fiber in the arterial wall, and these results correlate with arteriosclerosis and SWR of FS-T2WI.
It is deemed useful to evaluate arteriosclerosis objectively by using MRI, and T2- weighted images using radial scan (BLADE) is especially useful.
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| Academic Significance and Societal Importance of the Research Achievements |
動脈硬化病変の治療効果判定は、血中の脂質の測定で行われることが一般的である。直接血管壁の評価を行っているわけではない。MRIを用いて治療効果の判定を行うことが出来れば、全身の血管の治療効果の過程を可視化することが出来、有用性が高い。我々は、治療効果の判定にMRIを使用できることを証明した。
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