Establishment of early detection and treatment assessment of pulmonary hypertension by PC-cine MRI

Research Project

Project/Area Number	16K10323
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Radiation science
Research Institution	University of the Ryukyus
Principal Investigator	Murayamma Sadayuki 琉球大学, 医学(系)研究科(研究院), 教授 (60239548)
Co-Investigator(Kenkyū-buntansha)	山直也札幌医科大学, 医学部, 講師 (20404709) 畠中正光札幌医科大学, 医学部, 教授 (40253413) 岩澤多恵横浜市立大学, 医学研究科, 客員教授 (40625175) 土屋奈々絵琉球大学, 医学部附属病院, 医員 (70647354)
Project Period (FY)	2016-04-01 – 2019-03-31
Project Status	Completed (Fiscal Year 2018)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000) Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	PC-MRI / 肺高血圧症 / 治療効果 / 肺高血圧 / MRI / フェーズコントラストMRI / 肺動脈 / 流速測定
Outline of Final Research Achievements	Phase contrast MRI (PC-MRI) can determine pulmonary hemodynamics noninvasively. Pulmonary hypertension causes changes in pulmonary hemodynamics and is a factor for acute exacerbation and death in interstitial lung diseases (ILD). The purpose of this study was to determine the association between pulmonary hemodynamics measured by PC-MRI and episodes of acute exacerbations and death in patients with ILD related pulmonary hypertension. Reduction in right cardiac output, as detected by PC-MRI, was associated with acute exacerbation and increased mortality in ILD. MR examination to detect right ventricular dysfunction is useful for predicting the poor prognosis in fibrotic ILD patients, even if they are not combined with pulmonary hypertension.
Academic Significance and Societal Importance of the Research Achievements	本研究により，PC-MRIが間質性肺炎に関連した肺高血圧症の予後評価に有用であることが判明した。肺高血圧症の確定診断や予後評価には侵襲的な右心カテーテル検査が必須であるが，非侵襲的な検査方法であるPC-MRIによる評価を組み合わせて利用することにより，経過観察目的の右心カテーテル検査の頻度を少なくできる可能性がある。これにより，患者負担および医療費の軽減が期待できる。