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Diffusional Kurtosis Imaging, Neurite orientation and dispersion and density imaging-based whole brain analysis reveals occult brain damages in multiple sclerosis

Research Project

Project/Area Number 16K10327
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionJuntendo University

Principal Investigator

YOSHIDA MARIKO  順天堂大学, 医学部, 非常勤助教 (30755525)

Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords多発性硬化症 / 視神経炎 / DKI / NODDI / TBSS / ミエリンマップ / コネクトーム / 視神経脊髄炎 / g-ratio / DTI / NABT / optic pathway / visual evoked potentials / 脳神経疾患 / 脳・神経 / 神経科学 / 画像診断
Outline of Final Research Achievements

MRI can quantify pathological changes occurring the normal appearing brain tissue (NABT) and normal appearing gray matter (NAGM) in multiple sclerosis (MS).In this research, we demonstrated the ability of neurite orientation dispersion and density imaging (NODDI) combined with diffusional kurtosis imaging(DKI) and synthetic MRI, were able to detect in vivo evaluation of MS patients.In another study, we evaluated the brain network topology in MS using connectomes with connectivity strengths based on the ratio of the inner to outer myelinated axon diameter (i.e., g-ratio), thereby providing enhanced sensitivity to demyelination compared with the conventional measures of connectivity.
They provide more precise diffusional information derived from the WM and GM microstructural changes of the brain tissue than conventional diffusion analysis such as fractional anisotropy (FA) acquired by diffusion tensor imaging (DTI).

Academic Significance and Societal Importance of the Research Achievements

MS患者において、拡散テンソル解析に加えてDKIやsynthetic MRI併用によるNODDI、コネクトーム解析を行った報告は未だ少ない。脳内の異常を定量的に評価できる拡散解析は、病態生理の解明に寄与し学術的にも意義がある。これまでの研究で、MS患者のNABTや皮質の異常を鋭敏に捉えことができ、臨床症状との相関を得た。これらの指標による変化がどのような微細構造の変化に基づいているのか解明できる可能性がある。今後これらのイメージングがMS患者の治療において反応性の評価や早期診断に有用であることが確立されればMS患者の新規治療薬の有効性の評価や早期の治療開始の判断に有用であることが期待される。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (10 results)

All 2019 2016

All Journal Article (8 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results,  Open Access: 7 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] MR g-ratio-weighted connectome analysis in patients with multiple sclerosis2019

    • Author(s)
      Kamagata Koji、Zalesky Andrew、Yokoyama Kazumasa、Andica Christina、Hagiwara Akifumi、Shimoji Keigo、Kumamaru Kanako K.、Takemura Mariko Y.、Hoshino Yasunobu、Kamiya Kouhei、Hori Masaaki、Pantelis Christos、Hattori Nobutaka、Aoki Shigeki
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 13522-13522

    • DOI

      10.1038/s41598-019-50025-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Brain tissue and myelin volumetric analysis in multiple sclerosis at 3T MRI with various in-plane resolutions using synthetic MRI.2019

    • Author(s)
      Saccenti L, Andica C, Hagiwara A, Yokoyama K, Takemura MY, Fujita S, Maekawa T, Kamagata K, Le Berre A, Hori M, Hattori N, Aoki S.
    • Journal Title

      Neuroradiology.

      Volume: 11 Issue: 11 Pages: 1219-1227

    • DOI

      10.1007/s00234-019-02241-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Three-dimensional high-resolution simultaneous quantitative mapping of the whole brain with 3D-QALAS: An accuracy and repeatability study2019

    • Author(s)
      Fujita Shohei、Hagiwara Akifumi、Hori Masaaki、Warntjes Marcel、Kamagata Koji、Fukunaga Issei、Andica Christina、Maekawa Tomoko、Irie Ryusuke、Takemura Mariko Yoshida、Kumamaru Kanako Kunishima、Wada Akihiko、Suzuki Michimasa、Ozaki Yutaka、Abe Osamu、Aoki Shigeki
    • Journal Title

      Magnetic Resonance Imaging

      Volume: 63 Pages: 235-243

    • DOI

      10.1016/j.mri.2019.08.031

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gray Matter Alterations in Early and Late Relapsing-Remitting Multiple Sclerosis Evaluated with Synthetic Quantitative Magnetic Resonance Imaging2019

    • Author(s)
      Andica Christina、Hagiwara Akifumi、Kamagata Koji、Yokoyama Kazumasa、Shimoji Keigo、Saito Asami、Takenaka Yuki、Nakazawa Misaki、Hori Masaaki、Cohen-Adad Julien、Takemura Mariko Yoshida、Hattori Nobutaka、Aoki Shigeki
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 8147-8147

    • DOI

      10.1038/s41598-019-44615-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 3D quantitative synthetic MRI‐derived cortical thickness and subcortical brain volumes: Scan?rescan repeatability and comparison with conventional T 1 ‐weighted images2019

    • Author(s)
      Fujita Shohei、Hagiwara Akifumi、Hori Masaaki、Warntjes Marcel、Kamagata Koji、Fukunaga Issei、Goto Masami、Takuya Haruyama、Takasu Kohei、Andica Christina、Maekawa Tomoko、Takemura Mariko Yoshida、Irie Ryusuke、Wada Akihiko、Suzuki Michimasa、Aoki Shigeki
    • Journal Title

      Journal of Magnetic Resonance Imaging

      Volume: ahead of print Issue: 6 Pages: 1-9

    • DOI

      10.1002/jmri.26744

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Improving the Quality of Synthetic FLAIR Images with Deep Learning Using a Conditional Generative Adversarial Network for Pixel-by-Pixel Image Translation2019

    • Author(s)
      Hagiwara A.、Otsuka Y.、Hori M.、Tachibana Y.、Yokoyama K.、Fujita S.、Andica C.、Kamagata K.、Irie R.、Koshino S.、Maekawa T.、Chougar L.、Wada A.、Takemura M.Y.、Hattori N.、Aoki S.
    • Journal Title

      American Journal of Neuroradiology

      Volume: 40 Issue: 2 Pages: 224-230

    • DOI

      10.3174/ajnr.a5927

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alterations of the optic pathway between unilateral and bilateral optic nerve damage in multiple sclerosis as revealed by the combined use of advanced diffusion kurtosis imaging and visual evoked potentials2016

    • Author(s)
      Mariko Yoshida, Masaaki Hori, Kazumasa Yokoyama, Nozomi Hamasaki, Michimasa Suzuki, Koji Kamagata, Kouhei Kamiya, Yuriko Suzuki, Shinsuke Kyogoku, Yoshitaka Masutani, Nobutaka Hattori, Shigeki Aoki
    • Journal Title

      Magnetic resonance imaging

      Volume: 未定 Pages: 24-30

    • DOI

      10.1016/j.mri.2016.04.011

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 視神経脊髄炎関連疾患(neuromyelitis optica spectrum disorder:NMOSD)2016

    • Author(s)
      吉田茉莉子, 青木茂樹
    • Journal Title

      脊椎脊髄ジャーナル

      Volume: 29 Pages: 889-899

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] White Matter Analysis of Multiple Sclerosis with Quantitative Synthetic MRI and Neurite Orientation Dispersion and Density Imaging2019

    • Author(s)
      Akifumi Hagiwara, Koji Kamagata, Masaaki Hori, Christina Andica, Mana Kuramochi, Mariko Yoshida Takemura, Osamu Abe, Shigeki Aoki
    • Organizer
      7th International Congress on Magnetic Resonance Imaging (ICMRI 2019) and 24th Scientific Meeting of KSMRM
    • Related Report
      2018 Research-status Report
  • [Presentation] 多発性硬化症患者のSynthetic MRIとNODDIによる白質障害の評価:TBSS解析2019

    • Author(s)
      萩原 彰文、鎌形康司、堀 正明、横山和正、クリスティナ アンディカ、竹村(吉田)茉莉子、前川朋子、藤田翔平、入江隆介、和田昭彦、阿部 修、青木 茂樹
    • Organizer
      第48回日本神経放射線学会 2019年2月14日
    • Related Report
      2018 Research-status Report

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Published: 2016-04-21   Modified: 2021-02-19  

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