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Establishment of evaluation methods for spine and spinal cord disease by using multi-modal MR imaging technique

Research Project

Project/Area Number 16K10328
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionJuntendo University

Principal Investigator

HORI Masaaki  順天堂大学, 医学部, 准教授 (40334867)

Research Collaborator STIKOV Nikola  
COHEN-ADAD Julien  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords脊髄MRI / 拡散定量値 / ミエリン定量 / NODDI / g-ratio / 再生医療 / MRI / 脊髄 / 微細構造変化 / 定量的評価 / マルチモーダル / 定量化 / 髄鞘イメージ / 脊髄脊椎疾患
Outline of Final Research Achievements

Quantitative analysis using multi-modal MR imaging seemed to be promising tool, i.e. for monitoring of regenerating process of injured spinal cord. However, its application for in vivo clinical use has been difficult. We tried to optimize multi-modal MR imaging technique including diffusion weighted imaging, such as simultaneous multi-slice(SMS) readout segmentation of long variable echo-trains and myelin-specific MR imaging and related post imaging analysis procedure, and to apply these results for the clinical spine and spinal cord imaging in vivo. Moreover, unexpected new technique for imaging analysis (i.e. Spinal Cord Toolbox, quantitative spinal cord imaging analysis tool) has been added to our study during investigation. Our results showed that multi-modal MR imaging and analysis provided the information of microstructural changes in the spinal cord in vivo in patients with cervical spondylosis, which macrostructural conventional MR imaging did not provided.

Academic Significance and Societal Importance of the Research Achievements

本研究の結果はマルチモーダル磁気共鳴イメージングによる脊髄内の微細構造解析が、臨床でも使用可能であることを示した。
現在臨床で多く用いられる形態的なMRIでは捉えることが困難な、病的状態における脊髄内の微細構造変化を評価することが可能であることを意味しており、今後普及すると考えられる神経再生医療などにおける、定量的かつ客観的なモニタリングの手法として重要な意義がある結果として認識できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (12 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (5 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Int'l Joint Research] NeuroPoly(カナダ)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] Polytechnique Montréal(カナダ)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] Polytechnique Montréal(カナダ)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Automatic segmentation of the spinal cord and intramedullary multiple sclerosis lesions with convolutional neural networks2019

    • Author(s)
      Gros Charley、...Hori Masaaki、...、Cohen-Adad Julien
    • Journal Title

      NeuroImage

      Volume: 184 Pages: 901-915

    • DOI

      10.1016/j.neuroimage.2018.09.081

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Spatial distribution of multiple sclerosis lesions in the cervical spinal cord2019

    • Author(s)
      Eden Dominique、...、Hori Masaaki、...、Cohen-Adad Julien
    • Journal Title

      Brain

      Volume: 142 Issue: 3 Pages: 633-646

    • DOI

      10.1093/brain/awy352

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 特集 画像診断の別の貌-定量化と正常値のまとめ,適正使用と被曝 脊髄2018

    • Author(s)
      堀 正明, 萩原 彰文, 神谷 昂平, 鶴島 康晃, 福永 一星, 鶴田 航平, 青木 茂樹
    • Journal Title

      脊椎脊髄ジャーナル

      Volume: 31 Issue: 9 Pages: 811-817

    • DOI

      10.11477/mf.5002200955

    • ISSN
      0914-4412
    • Year and Date
      2018-09-25
    • Related Report
      2018 Annual Research Report
  • [Journal Article] Application of Quantitative Microstructural MR Imaging with Atlas-based Analysis for the Spinal Cord in Cervical Spondylotic Myelopathy2018

    • Author(s)
      Hori M, Hagiwara A, Fukunaga I, Ueda R, Kamiya K, Suzuki Y, Liu W, Murata K, Takamura T, Hamasaki N, Irie R, Kamagata K, Kumamaru KK, Suzuki M, Aoki S.
    • Journal Title

      Sci Rep

      Volume: 8 Issue: 1 Pages: 5213-5213

    • DOI

      10.1038/s41598-018-23527-8

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Application of neurite orientation dispersion and density imaging or diffusion tensor imaging to quantify the severity of cervical spondylotic myelopathy and to assess postoperative neurologic recovery.2018

    • Author(s)
      Okita G, Ohba T, Takamura T, Ebata S, Ueda R, Onishi H, Haro H, Hori M.
    • Journal Title

      Spine J

      Volume: 18 Issue: 2 Pages: 268-275

    • DOI

      10.1016/j.spinee.2017.07.007

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 軽度頚椎症患者の障害側を各種MRI定量値の値をもとにU-netで推測する2018

    • Author(s)
      堀正明, 大塚裕次朗,福永一星, 萩原彰文,入江隆介, 神谷昂平 , 鎌形康司,隈丸加奈子,鈴木通真, 和田昭彦,青木茂樹
    • Organizer
      第47回日本神経放射線学会
    • Related Report
      2017 Research-status Report
  • [Presentation] Application of Quantitative Microstructural MR Imaging with Atlas-based Analysis for Spinal Cord in Cervical Spondylotic Myelopathy2017

    • Author(s)
      Masaaki Hori , Issei Fukunaga , Ryo Ueda , Kouhei Kamiya , Yuichi Suzuki , Katsutoshi Murata , Tomohiro Takamura , Nozomi Hamasaki , Ryusuke Irie , Kanako Kunishima Kumamaru , Michimasa Suzuki , Shigeki Aoki
    • Organizer
      ISMRM 25th Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantitative MR Imaging in Spinal Cord: the Basics and Clinical Applications2016

    • Author(s)
      堀正明、野尻龍二、鶴島康晃、萩原彰文、隈丸加奈子、鎌形康司、入江 隆介、鈴木通真、青木茂樹
    • Organizer
      第102回北米放射線学会
    • Place of Presentation
      米国シカゴ
    • Year and Date
      2016-11-27
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 脊髄脊椎MRIの現状と展望2016

    • Author(s)
      堀正明
    • Organizer
      第25回山梨画像診断研究会
    • Place of Presentation
      山梨県甲府市
    • Related Report
      2016 Research-status Report
    • Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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