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Investigation of body fluid biomarkers for bone marrow failure in acute radiation syndrome using metabolomics

Research Project

Project/Area Number 16K10339
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionHirosaki University

Principal Investigator

Monzen Satoru  弘前大学, 保健学研究科, 講師 (20514136)

Research Collaborator Mariya Yasushi  
Wojcik Andrzej  
Chiba Mitsuru  
Tatara Yota  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords急性放射線骨髄障害 / 骨髄抑制 / メタボローム / 造血細胞 / 骨髄微小環境 / メタボロミクス解析 / 造血前駆細胞 / 致死放射線量 / 重症度予測 / 尿中代謝産物 / 被ばく医療 / 線量依存性 / 放出パーターベーション / メタボロミクス / 生体内パーターベーション / 造血システム
Outline of Final Research Achievements

The aim of this study was to identify specific radiation biomarkers for acute radiation syndrome, especially as predictive markers for severity, using the metabolome technique. A metabolome analysis was performed for body fluid extracted from a mouse model, and the time and/or radiation dose characteristics after exposure to ionising radiation were estimated. We found that microRNAs in serum and some nucleic acid/lipid oxidations in urine significantly changed within 72 h after exposure to a dose range inducible to bone marrow failure and lethal dose when compared with the findings in non-irradiated controls. These results suggest that some metabolites in body fluids might be useful as quick triage tools in a radiation emergency or as markers of the side effects of radiotherapy.

Academic Significance and Societal Importance of the Research Achievements

本研究課題の成果は、極めて多量の電離放射線に曝された場合(例えば不慮の放射線事故や癌放射線治療での骨髄近傍への照射)、発症が想定される血液の血球減少を早期に予測するための被ばくマーカーとして役立つことが想定され、特に致死線量は明確に推定できるかもしれない。もし被ばく後早期にその医療対応が進めば、被ばく事故での救命や癌治療副作用の軽減が期待できる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (42 results)

All 2019 2018 2017 2016 Other

All Int'l Joint Research (3 results) Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 5 results,  Acknowledgement Compliant: 1 results) Presentation (31 results) (of which Int'l Joint Research: 6 results) Remarks (1 results)

  • [Int'l Joint Research] ストックホルム大学(スウェーデン)

    • Related Report
      2018 Annual Research Report
  • [Int'l Joint Research] ストックホルム大学・放射線防護研究センター(スウェーデン)

    • Related Report
      2017 Research-status Report
  • [Int'l Joint Research] ストックホルム大学・放射線防護研究センター(スウェーデン)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Malondialdehyde: a urinary toxic biomarker for unexpected exposure to high-dose ionizing radiation2019

    • Author(s)
      Monzen S, Chiba M, Mariya Y
    • Journal Title

      Rinsho Byori

      Volume: 67(3) Pages: 212-215

    • NAID

      40021862154

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Urinal biomarker, 8-Hydroxy-2’-Deoxyguanosine, for unexpected exposure dose of ionizing radiation2018

    • Author(s)
      Monzen S, Terada K, Morino Y, Chiba M
    • Journal Title

      Cytometry Research

      Volume: 28 Issue: 1 Pages: 41-45

    • DOI

      10.18947/cytometryresearch.28.1_41

    • NAID

      130007378932

    • ISSN
      0916-6920, 2424-0664
    • Year and Date
      2018-05-25
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protective Effect of the c-mpl Agonist Romiplostim on Megakaryocytopoiesis of Human CD34+ Hematopoietic Progenitor Cells Exposed to Ionizing Radiation.2018

    • Author(s)
      Monzen S, Kimura S, Yamaguchi M, Kashiwakura I
    • Journal Title

      J Interferon Cytokine Res

      Volume: 38 Issue: 5 Pages: 206-212

    • DOI

      10.1089/jir.2017.0104

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A radioresistant fraction of acute promyelocytic leukemia cells exhibit CD38 cell-surface antigen and mRNA expression2018

    • Author(s)
      Monzen Satoru、Chiba Mitsuru、Ueno Tatsuya、Morino Yuki、Terada Kenji、Yamaya Hiroki、Hosokawa Yoichiro
    • Journal Title

      Oncology Letters

      Volume: 15(5) Pages: 6709-6714

    • DOI

      10.3892/ol.2018.8099

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum miR-375-3p increase in mice exposed to a high dose of ionizing radiation2018

    • Author(s)
      Chiba Mitsuru、Monzen Satoru、Iwaya Chihiro、Kashiwagi Yuri、Yamada Sunao、Hosokawa Yoichiro、Mariya Yasushi、Nakamura Toshiya、Wojcik Andrzej
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 1302-1302

    • DOI

      10.1038/s41598-018-19763-7

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ascorbic acid does not reduce the anticancer effect of radiotherapy.2017

    • Author(s)
      Hosokawa Y, Saga R, Monzen S, Terashima S, Tsuruga E.
    • Journal Title

      Biomed Rep.

      Volume: 6(1) Issue: 1 Pages: 103-107

    • DOI

      10.3892/br.2016.819

    • NAID

      120006559351

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anti-tumor and anti-invasion effects of a combination of 4-methylumbelliferone and ionizing radiation in human fibrosarcoma cells.2017

    • Author(s)
      Saga R, Monzen S, Chiba M, Yoshino H, Nakamura T, Hosokawa Y.
    • Journal Title

      Oncol Lett.

      Volume: 13(1) Issue: 1 Pages: 410-416

    • DOI

      10.3892/ol.2016.5385

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 放射線被ばく時の急性骨髄障害における治療法の検討2018

    • Author(s)
      門前暁, 千葉満, 真里谷靖
    • Organizer
      第65回日本臨床検査医学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 尿中代謝産物を利用したバイオドシメトリ―の検討2018

    • Author(s)
      門前暁, 寺田賢司, 森野友貴, 佐藤孝徳, 千葉満
    • Organizer
      日本放射線影響学会第61回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 高線量率被ばくマウスの骨髄中造血前駆細胞の損傷の特徴2018

    • Author(s)
      森野友貴, 寺田賢司, 佐藤孝徳, 千葉満, Wojcik Andrzej, 門前暁
    • Organizer
      日本放射線影響学会第61回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 急性放射線障害に対する医療技術の検討 ~骨髄障害の重症化軽減を目指して~2018

    • Author(s)
      森野 友貴, 千葉 満, Andrzej Wojcik, 真里谷 靖, 門前 暁
    • Organizer
      平成30年度放射線安全取扱部会年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 尿を用いたバイオドシメトリの検討2018

    • Author(s)
      佐藤 孝徳, 寺田賢司, 真里谷 靖, 門前 暁
    • Organizer
      平成30年度放射線安全取扱部会年次大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] CHARACTERISTICS OF BONE MARROW SUBPOPULATION IN A MOUSE MODEL UNDER HIGH DOSE RATE IONIZING RADIATION EXPOSURE2018

    • Author(s)
      Morino Y, Monzen S, Chiba M, Kamatsuka M, Fukui A, Mariya Y, Wojcik A
    • Organizer
      The 33rd World Congress of Biomedical Laboratory Science (IFBLS)
    • Related Report
      2018 Annual Research Report
  • [Presentation] 尿中代謝物に着目した放射線被ばくの線量評価マーカーの探索2017

    • Author(s)
      門前 暁, 寺田 賢司, 多和田 侑介, 真里谷 靖, Andrzej Wojcik
    • Organizer
      2017年度生命科学系学会合同年次大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 去勢抵抗性前立腺癌骨転移患者に対するRa-223内照射と腫瘍・骨代謝・酸化ストレスマーカーの経時的推移2017

    • Author(s)
      真里谷 靖, 門前 暁, 千葉 満
    • Organizer
      第64回日本臨床検査医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 尿中代謝産物をバイオマーカーとした放射線被ばく影響の評価2017

    • Author(s)
      門前 暁, 千葉 満, 真里谷 靖
    • Organizer
      第64回日本臨床検査医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 被ばくバイオマーカーとしての血中循環microRNAの検討2017

    • Author(s)
      千葉 満, 門前 暁, 真里谷 靖
    • Organizer
      第64回日本臨床検査医学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] biomarker of acute radiation syndrome: miR-375-3p increases in mouse serum by exposure to lethal/sublethal dose2017

    • Author(s)
      Chiba M, Monzen S, Mariya Y
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Urinary biomarkers of lethal/sublethal ionizing radiation doses2017

    • Author(s)
      Monzen S, Chiba M, Mariya Y
    • Organizer
      The 29th World Congress of World Association of Societies of Pathology and Laboratory Medicine (WASPaLM2017)
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 高線量率放射線による骨髄細胞の損傷とsubpopulationの特徴2017

    • Author(s)
      森野 友貴, 高坂 望美, 鎌塚 みさと, 福井 麻未, 千葉 満, Andrzej Wojcik, 門前 暁
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 放射線治療における線量最適化を目的とした細胞外micro RNA発現の利用検討2017

    • Author(s)
      上野 達也, 門前 暁, 千葉 満, 細川 洋一郎
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 尿中代謝産物に着目した放射線被ばくマーカーの探索2017

    • Author(s)
      寺田 賢司, 多和田 侑介, 千葉 満, 真里谷 靖, 門前 暁
    • Organizer
      日本放射線影響学会第60回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 尿中代謝物に着目した緊急時バイオドシメトリの基礎的検証2017

    • Author(s)
      門前 暁, 寺田 賢司, 多和田 侑介, 真里谷 靖, 千葉 満, Andrzej Wojcik
    • Organizer
      平成29年度放射線安全取扱部会年次大会
    • Related Report
      2017 Research-status Report
  • [Presentation] Serum microRNAs for early diagnosis of acute radiation syndrome2017

    • Author(s)
      Chiba M, Monzen S
    • Organizer
      The 9th JARI Annual Meeting, The 4th JSEV Annual Meeting
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 放射線被ばく線量推定のための尿中バイオマーカーの探索2017

    • Author(s)
      門前暁, 多和田侑介, 千葉満, 高坂望美, 森野友貴, 山屋大樹, 上野達也, Wojcik Andrzej
    • Organizer
      第27回日本サイトメトリー学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 生物学的評価による放射線治療線量の最適化のための基礎的検討2017

    • Author(s)
      上野達也, 門前暁, 千葉満, 細川洋一郎
    • Organizer
      第27回日本サイトメトリー学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 致死線量放射線被ばくバイオマーカーとしての血中循環microRNA2017

    • Author(s)
      千葉満, 門前暁
    • Organizer
      第27回日本サイトメトリー学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Basic investigation to optimize radiation dose using biological information in radiotherapy2017

    • Author(s)
      Ueno T, Monzen S, Chiba M, Hosokawa Y
    • Organizer
      the 73th annual scientific congress of the Japanese Society of Radiological Technology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 放射線被ばくに対する生物学的線量評価の有効性の確認と新たな取組み.2016

    • Author(s)
      門前 暁, 千葉 満, Lovisa Lundholm, Andrzej Wojcik.
    • Organizer
      平成28年度放射線安全取扱部会年次大会.
    • Place of Presentation
      鎌倉芸術館(神奈川県鎌倉市)
    • Year and Date
      2016-11-10
    • Related Report
      2016 Research-status Report
  • [Presentation] ヒト白血病細胞における放射線抵抗性獲得後の細胞外小胞mRNA発現の特徴.2016

    • Author(s)
      門前 暁, 千葉 満, Wojcik Andrzej, 真里谷 靖, 細川 洋一郎.
    • Organizer
      日本放射線影響学会第59回大会.
    • Place of Presentation
      JMSアステールプラザ(広島県広島市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 血清中循環microRNA に着目した急性放射線症候群バイオマーカー.2016

    • Author(s)
      千葉 満, 門前 暁.
    • Organizer
      日本放射線影響学会第59回大会.
    • Place of Presentation
      JMSアステールプラザ(広島県広島市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report
  • [Presentation] ヒト前立腺癌細胞株に対するX 線照射によるヒアルロン酸への影響.2016

    • Author(s)
      村田 晃祥, 上野 達也, 嵯峨 涼, 門前 暁, 細川 洋一郎.
    • Organizer
      日本放射線影響学会第59回大会.
    • Place of Presentation
      JMSアステールプラザ(広島県広島市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report
  • [Presentation] ヒト線維肉腫細胞に対する4-methylumbelliferone 投与と放射線併用による放射線増感効果.2016

    • Author(s)
      嵯峨 涼, 門前 暁, 千葉 満, 上野 達也, 村田 晃祥, 中村 敏也, 細川 洋一郎.
    • Organizer
      日本放射線影響学会第59回大会.
    • Place of Presentation
      JMSアステールプラザ(広島県広島市)
    • Year and Date
      2016-10-26
    • Related Report
      2016 Research-status Report
  • [Presentation] 血清中循環microRNAに着目した新たな生物学的被ばく線量評価法の検討.2016

    • Author(s)
      千葉満, 門前暁.
    • Organizer
      第63回日本臨床検査医学会学術集会.
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
  • [Presentation] 分化型甲状腺癌患者における放射性ヨウ素内用療法の効果及び有害事象を予測する因子の探索.2016

    • Author(s)
      門前暁, 千葉満, 真里谷靖.
    • Organizer
      第63回日本臨床検査医学会学術集会.
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
  • [Presentation] Serum microRNAs for early diagnosis of acute radiation syndrome Serum miR-375-3p as a biomarker for early diagnosis of acute radiation syndrome.2016

    • Author(s)
      Chiba M, Monzen S
    • Organizer
      The 32nd World Congress of Biomedical Laboratory Science (IFBLS2016)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2016-08-31
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Predictive biomarkers for detecting adverse effects using radioisotope ablation in patients with papillary thyroid carcinoma.2016

    • Author(s)
      Monzen S, Chiba M, Hosokawa Y, Mariya Y.
    • Organizer
      The 32nd World Congress of Biomedical Laboratory Science (IFBLS2016)
    • Place of Presentation
      神戸ポートアイランド(兵庫県神戸市)
    • Year and Date
      2016-08-31
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Introduction to the Education of Radiological Technologist using e-learning System in University of Health Sciences.2016

    • Author(s)
      Monzen S, Matsutani H
    • Organizer
      the 72th annual scientific congress of the Japanese Society of Radiological Technology
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Remarks] 弘前大学 研究者総覧

    • URL

      http://hue2.jm.hirosaki-u.ac.jp/html/100000121_ja.html

    • Related Report
      2017 Research-status Report 2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2022-02-22  

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