| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The aim of this study was to identify specific radiation biomarkers for acute radiation syndrome, especially as predictive markers for severity, using the metabolome technique. A metabolome analysis was performed for body fluid extracted from a mouse model, and the time and/or radiation dose characteristics after exposure to ionising radiation were estimated. We found that microRNAs in serum and some nucleic acid/lipid oxidations in urine significantly changed within 72 h after exposure to a dose range inducible to bone marrow failure and lethal dose when compared with the findings in non-irradiated controls. These results suggest that some metabolites in body fluids might be useful as quick triage tools in a radiation emergency or as markers of the side effects of radiotherapy.
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