| Project/Area Number |
16K10347
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kyoto College of Medical Science |
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Principal Investigator |
Shibata Toshiya 京都医療科学大学, 医療科学部, 教授 (60162632)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 生体肝移植 / LDLT / 吻合部狭窄 / IVR / intervention / 可溶性ドレナージカテーテル / 脈管吻合部狭窄 / 経皮的バルーン拡張術 / メタリックステント挿入術 / 胆管狭窄 / 門脈狭窄 / 肝静脈狭窄 / 生体吸収性ステント / フレキシマカテーテル / インターベンショナルラジオロジー(IVR) |
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| Outline of Final Research Achievements |
Interventional radiology, such as percutaneous balloon dilatation or stent placement is an effective treatment for anastomotic venous or biliary stricture after living liver donor transplantation. However, there are a few cases where recurrent stricture occurs after repeated interventions. The purpose of our study was initially to apply absorb stent for the treatment recurrent anastomotic stricture. But off-label use of coronary absorb stent was difficult. So, animal studies using a Flexima catheter which is a biliary drainage catheter with dissolution of the catheter tip were performed. In the animal studies, dissolution of the catheter tip and patency of the wider lumen was achieved. A dissolve biliary catheter can be used for recurrent biliary stricture after living liver donor transplantation in the future.
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| Academic Significance and Societal Importance of the Research Achievements |
小児胆道閉鎖症例では、左葉生体肝移植が施行されることが多く胆管吻合は胆管-空腸吻合が行われる。胆管-空腸吻合後の術後胆管狭窄に対しては一般的にPTBD（percutaneous transhepatic biliary drainage）が施行される。PTBDルートでinner drainageが可能となっても、ドレナージカテーテルは体外にでた状態で日常生活を送ることになり、小児患者にとって苦痛が大きい。将来可溶性ドレナージチューブが治療に用いられると、より容易にカテーテルフリーの状態が達成できる可能性があり、患者さんのQOL向上に役立つものと考えられる。
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