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Cryoablation for myoma uteri under reflux flow of hot saline solution into the intrauterine cavity

Research Project

Project/Area Number 16K10352
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionKochi University

Principal Investigator

YAMAGAMI TAKUJI  高知大学, 教育研究部医療学系臨床医学部門, 教授 (10257537)

Co-Investigator(Kenkyū-buntansha) 吉松 梨香  高知大学, 教育研究部医療学系臨床医学部門, 助教 (10607592)
岡本 芳晴  鳥取大学, 農学部, 教授 (50194410)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords凍結療法 / 子宮筋腫 / インターベンショナルラジオロジー
Outline of Final Research Achievements

Uterine temperature during cryoablation tended to be higher in cases perforemd under reflux flow of hot saline solution into the intrauterine cavity. Damage to the uterine was same or more serious in cases without reflux flow compared with cases with reflux flow. In the area temperature was higher than -30℃ damage to the mormal tissue was more mild. On the other hand, in the area temperature was lower than -30℃ damage to the mormal tissue was stronger.
From this study, when cryoablation for uterine myoma is performed, it might be suggested that reflux flow of hot saline solution is useful to prevent damage to the normal tissues.

Academic Significance and Societal Importance of the Research Achievements

腎癌に対する凍結療法は、平成24年3月に保険適用となって以来、急速に広まりつつある。一方、子宮筋腫に対しても、本治療法は新しい低侵襲性治療として期待が高まっている。特に治療の際の痛みが非常に少ないという大きな利点がある。しかし、新しい治療法であるため、どのような凍結療法プログラムを組むことが、子宮筋腫に対して最も治療効果が高くなるか明らかではない。また、子宮内膜や卵巣への影響など未知の問題も多い。本研究で、子宮腔内に加温水を還流しつつ凍結療法を行うことにより、病変のみを凍結し正常子宮内膜をより温存することができる可能性が示唆された点が意義深い。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (9 results)

All 2019 2018 2016

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results)

  • [Journal Article] Protection from injury of organs adjacent to a renal tumor during percutaneous cryoablation2019

    • Author(s)
      Yamagami T, Yoshimatsu R, Kajiwara K, Yamanishi T, Minamiguchi H, Karashima T, Inoue K.
    • Journal Title

      Int J Urol.

      Volume: 26 Issue: 8 Pages: 785-790

    • DOI

      10.1111/iju.14013

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Time-Dependent Effects of Cryoablation for Renal Tumor on Overall and Split Renal Function2019

    • Author(s)
      Yoshimatsu R, Yamagami T, Nishimori M, Ogi K, Murata Y, Iwasa H, Kajiwara K, Yamanishi T, Minamiguchi H, Karashima T, Inoue K
    • Journal Title

      J Vasc Interv Radiol

      Volume: 30 Issue: 3 Pages: 460-465

    • DOI

      10.1016/j.jvir.2018.10.017

    • Related Report
      2018 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prediction of the ablated area prior to radiofrequency ablation for liver tumor under CT guidance2018

    • Author(s)
      Yoshimatsu R, Doi A, Yamanishi T, Nishimori M, Ogi K, Kajiwara K. Tamura T, Minamiguchi H, Yamagami T.
    • Journal Title

      Minim Invasive Ther Allied Technol

      Volume: 27 Issue: 1 Pages: 22-26

    • DOI

      10.1080/13645706.2017.1407799

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Change in Imaging Findings on Angiography-Assisted CT During Balloon-Occluded Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma2016

    • Author(s)
      Yoshimatsu R, Yamagami T, Ishikawa M, Kajiwara K, Aikata H, Chayama K, Awai K
    • Journal Title

      Cardiovasc Intervent Radiol

      Volume: 39 Issue: 6 Pages: 865-874

    • DOI

      10.1007/s00270-015-1279-9

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Therapeutic response to a novel enzyme-targeting radiosensitization treatment (Kochi Oxydol-Radiation Therapy for Unresedctable carcinomas) in patients with recurrent breast cancer2016

    • Author(s)
      Aoyama N, Ogawa Y, Yasuoka M, Takahashi M, Iwasa H, Miyatake K, Yamanishi T, Hamada N, Tamura T, Nishioka A, Yamagami T
    • Journal Title

      Oncology Letters

      Volume: 11 Issue: 1 Pages: 1-6

    • DOI

      10.3892/ol.2016.4589

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Time-Dependent Effects of Cryoablation for Renal Tumor on Overall and Split Renal Function2019

    • Author(s)
      Yoshimatsu R, Yamagami T, Nishimori M, Ogi K, Murata Y, Iwasa H, Kajiwara K, Yamanishi T, Minamiguchi H, Karashima T, Inoue K
    • Organizer
      第48回日本IVR学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 異なる位置で交差する2本の凍結針により形成されるice ballの検討2019

    • Author(s)
      山下政矩、三浦寛司、廣田達哉、浅井俊輔、山端康之、辻悠佑、山田恵、高松洋、福永鷹信、山上卓士
    • Organizer
      第48回日本IVR学会総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Usefulness of transarterial infusion of iodized oil and gelatin particles for marking before CT-guided percutaneous cryoablation of renal cell carcinoma2019

    • Author(s)
      Kajiwara K, Yoshimatsu R, Nishimori M, Yamanishi T, Mianmiguchi H, Karashima T, Inoue K, Awai K, Yamagami T
    • Organizer
      CIRSE 2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Prediction of the ablated area prior to radiofrequency ablation for hepatocellular carcinoma under CT fluoroscopic guidance2018

    • Author(s)
      Yamagami T, Yoshimatsu R, Doi A, Yamanishi T, Kajiwara K, Minamiguchi H
    • Organizer
      SMIT2018-IBEC2018 Joint Conferecne 2018
    • Related Report
      2018 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2021-02-19  

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