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Assessment of the efficacy of RFA combined with intratumoral administration of cisplatin.

Research Project

Project/Area Number 16K10360
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionOsaka City University

Principal Investigator

Hamamoto Shinichi  大阪市立大学, 大学院医学研究科, 講師 (80711788)

Research Collaborator MURAI kazuki  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肺腫瘍 / RFA / シスプラチン / ラジオ波凝固療法 / 抗癌剤局所投与 / 肺癌 / 医療 / 癌
Outline of Final Research Achievements

The purpose of this study is to evaluate the feasibility of combination therapy of RFA and intratumoral cisplatin injection to lung tumor. VX2 tumor colonized rabbit models were prepared, and RFA and intratumoral cisplatin injection was performed. Rabbits modeles were randomly assigned to 4 groups of control group (untreated group), RFA alone group, intratumoral cisplatin injection group, RFA + ciplatin injection group. Survivals were evaluated by by the Kaplan-Meier method. The median survival time of the control group, RFA alone group, intratumoral cisplatin injection group, RFA + intratumoral cisplatin injection group were (24.5 / 40.0 / 31.0 / 80.0 days), respectively. The survival rates on the 20th, 40th, 60th, and 80th days were (62.5%, 0%, 0%, 0% / 100%, 50%, 25%, 25% / 62.5%, 25%, 12.5% , 12.5% / 100%, 100%, 75%, 62.5%). The survival time of the combination therapy group was significantly longer than the other 3 groups.

Academic Significance and Societal Importance of the Research Achievements

肺腫瘍に対するRFAは広く行われているが、約1~2割の局所再発が見られ、より成績を向上させることが求められている。今回、我々は、ウサギ腫瘍モデルを使用し、RFAとシスプラチン局所投与で予後の延長が得られることを示せた。肺RFAやシスプラチンの局所投与は、現在の臨床的な技術では容易であり、また、シスプラチンは臨床でも広く使用されている薬剤である。よって、今後、肺癌患者に対する臨床応用への基礎データとなり得るといえる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (5 results)

All 2019 2018 2016

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Therapeutic Effects of CT-guided Radiofrequency Ablation with Concurrent Platinum-Doublet Chemotherapy in a Rabbit VX2 Lung Tumor Model.2016

    • Author(s)
      Ueki A, Okuma T, Hamamoto S, Miki Y.
    • Journal Title

      Radiology.

      Volume: 印刷中 Issue: 2 Pages: 391-398

    • DOI

      10.1148/radiol.2016160414

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Subpleural Injection of Lidocaine Can Relieve Strong Pain During RFA for Lung Tumors. 2019

    • Author(s)
      Shinichi Hamamoto
    • Organizer
      Asian Pacific Society of Cardiovascular and Interventional Radiology (APSCVIR)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Radiofrequency ablation(RFA) for lung tumor with artificial pneumothorax2018

    • Author(s)
      Shinichi Hamamoto
    • Organizer
      Cardiovascular intervention Radiology(CIRSE2018)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Research of RFA to a lung tumor near bronchus2018

    • Author(s)
      Shinichi Hamamoto
    • Organizer
      Asian Pacific Society of Cardiovascular and Interventional Radiology (APSCVIR)
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Radiofrequency ablation to the pericardial lung tumor2018

    • Author(s)
      濵本晋一
    • Organizer
      日本IVR学会
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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