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Research and Development of effective training systems for minimally invasive therapies, such as radiofrequency ablation and others

Research Project

Project/Area Number 16K10363
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionJuntendo University

Principal Investigator

Shiina Shuichiro  順天堂大学, 医学(系)研究科(研究院), 教授 (70251238)

Co-Investigator(Kenkyū-buntansha) 崔 仁煥  順天堂大学, 医学部, 非常勤講師 (10255664)
石井 重登  順天堂大学, 医学部, 助手 (70625136)
金澤 亮  順天堂大学, 医学部, 助手 (30773600)
武田 裕子  順天堂大学, 医学部, 教授 (70302411)
今井 康晴  東京医科大学, 医学部, 准教授 (60439742)
高和 正  順天堂大学, 医学部, 准教授 (70458884)
清水 基規  順天堂大学, 医学部, 非常勤助手 (00809254)
永松 洋明  順天堂大学, 医学部, 准教授 (90289421)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsラジオ波焼灼術 / 肝癌 / 低侵襲治療 / トレーニングシステム / トレーニングプログラム / アンケート調査 / 治療技術の標準化 / スコアリング・システム / ラジオ波焼灼術(RFA) / 効果測定 / マイクロ波焼灼術(MWA) / ラジオ波治療 / ステント治療 / リザーバー治療
Outline of Final Research Achievements

Image-guided ablations, such as radiofrequency ablation (RFA) and microwave ablation (MWA), are highly operator-dependent. To disseminate skills for ablations we held 12 domestic training programs and 6 international ones. The programs were composed of lectures, live demonstrations and case studies. Lecture contents were about current status of ablations, ablation devices, ultrasonography, etc. In live demonstrations, ablations were performed on diverse cases: tumor below the diaphragm, in the caudate lobe, adjacent to the heart, portal vein or hepatic vein, over 5 centimeters etc. We demonstrated the importance of having appropriate patient posture, the usefulness of our dedicated probe and operation table, and ways to perform ablations under Sonazoid-guidance and with fusion imaging. In case studies, difficult to ablate cases from participants' hospitals were discussed. Our programs provided opportunities to understand basic concepts and learn essential technical tips in ablations.

Academic Significance and Societal Importance of the Research Achievements

このような技術や知識を学ぶトレーニングプログラムは他には存在せず、多くの受講者が集まった。韓国肝臓学会はこのプログラムを有用と評価し受講者の旅費等をサポートするようになった。プログラムにより受講者のモチベーションが上がり、人工胸腹水、fusion imagingなどの技術を学ぶことにより、受講後には多くの施設で症例数が増加した。根治性が高く低侵襲のラジオ波焼灼術の恩恵を多くの患者が得ることができるようになった。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (25 results)

All 2019 2018 2017 2016 Other

All Journal Article (9 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 8 results) Presentation (15 results) (of which Int'l Joint Research: 12 results,  Invited: 11 results) Remarks (1 results)

  • [Journal Article] Asia-Pacific clinical practice guidelines on the management of hepatocellular carcinoma: a 2017 update.2017

    • Author(s)
      Omata M1,2, Cheng AL3, Kokudo N4, Kudo M5, Lee JM6, Jia J7, Tateishi R8, Han KH9, Chawla YK10, Shiina S11, Jafri W12, Payawal DA13, Ohki T14, Ogasawara S15, Chen PJ16, Lesmana CRA17,18, Lesmana LA17, Gani RA18, Obi S19, Dokmeci AK20, Sarin SK21.
    • Journal Title

      HEPATOLOGY INTERNATIONAL

      Volume: 巻: 11 号: 4 Issue: 4 Pages: 317-370

    • DOI

      10.1007/s12072-017-9799-9

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful local treatment for repeated hepatic recurrences of cholangiolocellular carcinoma: a report on a long-term survivor.2017

    • Author(s)
      Shinohara K, Ebata T, Yokoyama Y, Igami T, Sugawara G, Mizuno T Yamaguchi J, Shimoyama Y, Shiina S, Tateishi R Arano T, Nagino M.
    • Journal Title

      Surg Case Rep

      Volume: 3 Issue: 1 Pages: 120-120

    • DOI

      10.1186/s40792-017-0391-2

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of MUC1 Expression on the Progression of Intraductal Papillary Mucinous Neoplasm With Worrisome Features During Follow-up.2017

    • Author(s)
      Tomishima K, Sai JK, Kanazawa R, Miura H, Shimizu R, Sato K, Ishii S, Saito H, Ito T, Fukumura Y, Shiina S, Watanabe S.
    • Journal Title

      Pancreas.

      Volume: 46巻 9号 Issue: 9 Pages: 1127-1132

    • DOI

      10.1097/mpa.0000000000000902

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hepatocellular carcinoma recurrence after curative treatments in patients with chronic hepatitis C who underwent direct-acting antiviral therapy2017

    • Author(s)
      Minami, T ; Tateishi, R ; Wake, T ; Nishibatake, M ; Nakagomi, R ; Sato, M ; Uchino, K ; Enooku, K ] ; Nakagawa, H ; Asaoka, Y ; Shiina, S
    • Journal Title

      HEPATOLOGY

      Volume: 66

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gadoxetic Acid-Enhanced MR Imaging Predicts Simeprevir-Induced Hyperbilirubinemia During Hepatitis C Virus Treatment: A Pilot Study2016

    • Author(s)
      Okubo H, Kitamura T, Ando H, Fukada H, Igusa Y, Kokubu S, Miyazaki A, Fujimura A, Shiina S, Watanabe S
    • Journal Title

      J Clin Pharmacol

      Volume: 57 Issue: 3 Pages: 369-375

    • DOI

      10.1002/jcph.811

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hepatocellular Carcinoma: The Role of Interventional Oncology.2016

    • Author(s)
      Donadon M, Solbiati L, Dawson L, Barry A, Sapisochin G, Greig PD, Shiina S, Fontana A, Torzilli G.
    • Journal Title

      Liver Cancer

      Volume: NOV6(1) Issue: 1 Pages: 34-43

    • DOI

      10.1159/000449346

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The impact of direct-acting antivirals on early tumor recurrence after radiofrequency ablation in hepatitis C-related hepatocellular carcinoma2016

    • Author(s)
      Minami T, Tateishi R, Nakagomi R, Fujiwara N, Sato M, Enooku K, Nakagawa H, Asaoka Y, Kondo Y, Shiina S, Koike K
    • Journal Title

      J Hepatol.

      Volume: 65 Issue: 6 Pages: 1272

    • DOI

      10.1016/j.jhep.2016.07.043

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impact of serum ferritin level on hepatocarcinogenesis in chronic hepatitis C patients.2016

    • Author(s)
      Uchino K, Tateishi R, Fujiwara N, Minami T, Sato M, Enooku K, Nakagawa H, Asaoka Y, Kondo Y, Yoshida H, Moriya K, Shiina S, Omata M, Koike K.
    • Journal Title

      Hepatol Res.

      Volume: Apr;46(4): Pages: 259-68

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 【大腸癌肝転移-最新の治療ストラテジー】 治療の実際 ラジオ波焼灼術(RFA)2016

    • Author(s)
      1.椎名秀一朗、佐藤公紀、清水遼、林学、谷木信仁、近藤祐嗣、浅岡良成、建石良介、小池和彦
    • Journal Title

      臨床外科

      Volume: 71 No4 Pages: 433-437

    • Related Report
      2016 Research-status Report
  • [Presentation] ラジオ波(RFA)および新世代マイクロ波(MWA)トレ―ニングプログラム2019

    • Author(s)
      椎名秀一朗
    • Organizer
      第53回日本成人病(生活習慣病)学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 順天堂IVO(ラジオ波&マイクロ波)トレ―ニングプログラム2018

    • Author(s)
      椎名秀一朗
    • Organizer
      第37回Microwave Surgery 研究会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Juntendo RFA Training Program2018

    • Author(s)
      Shiina, Shuichiro
    • Organizer
      APASL STC Yokohama
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Factors for respiratory depression and severe body movement during percutaneous radiofrequency ablation under deep sedation2017

    • Author(s)
      Sato K, Taniki N, Shimizu R, Hayashi M, Kanazawa R, Ishii S, Hatanaka T, Sai JK, Watanabe S, Shiina S.
    • Organizer
      APASL 2017, Shanghai, China
    • Place of Presentation
      Shanghai International Convention Center, 上海
    • Year and Date
      2017-02-15
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Usefulness of Radiofrequency Ablation Training Program for Liver Tumors2017

    • Author(s)
      Shuichiro Shiina
    • Organizer
      The Asian Pacific Association for the Study of the Liver Nagasaki 2017c
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Radiofrequency Ablation2017

    • Author(s)
      Shuichiro Shiina
    • Organizer
      The Asian Pacific Association for the Study of the Liver Nagasaki 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 「RFAの可能性を広げるー可変型だからできることー」2017

    • Author(s)
      椎名 秀一朗
    • Organizer
      第53回肝癌研究会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Radiofrequency ablation (RFA).2017

    • Author(s)
      Shuichiro Shiina
    • Organizer
      the Asian-Pacific Hepato-Pancreato-Biliary Association
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Radiofrequency ablation: over 10 years results, future perspective and training2017

    • Author(s)
      Shuichiro Shiina
    • Organizer
      The Asian Pacific Association for the Study of the Liver Mongolia 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 順天堂ラジオ波焼灼術トレ―ニングプログラム2017

    • Author(s)
      椎名 秀一朗
    • Organizer
      Microwave Surgery 研究会2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Radiofrequency ablation: TJ experience of over 12,000 treatments in 18 years2017

    • Author(s)
      Shuichiro Shiina
    • Organizer
      ACTA 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] International Radiofrequency Ablation (RFA) training program for liver tumors at Juntendo University, Japan. APDW20162016

    • Author(s)
      25.Shimizu R, Taniki N, Hayashi M, Kanazawa R, Miura H, Sato K, Ishii S, Hatanaka T, Sai JK, Watanabe S, Shiina S.
    • Organizer
      APDW2016
    • Place of Presentation
      神戸商工会議所会館 イベントホール, 神戸
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] HCC:20 years of thermal ablation: RFA: Results and lessons learned.2016

    • Author(s)
      Shiina S.
    • Organizer
      INTERNATIONAL ONCOLOGY SANS FRONTIERES
    • Place of Presentation
      ATA Hotel Expo Fiera, Milan Italy
    • Year and Date
      2016-07-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Radiofrequency ablation for liver tumors: over 10-year experience and future perspective.2016

    • Author(s)
      Shiina S.
    • Organizer
      APAITO (The 2nd Scientific Meeting of Asia-Pacific Association of Image-Guided Therapy in Oncology)
    • Place of Presentation
      Multifunctional Hall,Qingdao China
    • Year and Date
      2016-05-26
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] New Local Ablative Therapy for HCC2016

    • Author(s)
      Shiina S
    • Organizer
      APASL(Asian-Pacific Association for the Study of the Liver) Single-Topic Conference
    • Place of Presentation
      Paradise Hotel Busan, Korea
    • Year and Date
      2016-04-08
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Remarks] 順天堂大学大学院医学研究科 画像診断・治療学の医局公式ブログ

    • URL

      http://juntendo-livercancer.jp/

    • Related Report
      2016 Research-status Report

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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