Hybrid intervention for severe venous thromboembolism with stent-filter

• Project/Area Number: 16K10365
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: Nippon Medical School
• Principal Investigator: Tajima Hiroyuki 日本医科大学, 医学部, 教授 (00188244)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 静脈血栓塞栓症 / Intervention / Interventional Radiology / Thrombectomy / Aspiration / Interventiona Radiology / 放射線 / 循環器・高血圧 / 臨床

Outline of Final Research Achievements

The purpose of this research was to make a hybrid interventional therapy for severe venous thromboembolism with a newly-developed stent-filter. Development and fundamental research was achieved, but animal experiment was failed and difficult to move on to the clinical process. On the other hand, we retrospectively analyzed the late outcomes of hybrid catheter intervention, and showed that the 10-year survival rate was 74.5±9.0 %, by Kaplan-Mayer survival analysis, which was comparable with surgical embolectomy.

Academic Significance and Societal Importance of the Research Achievements

重症静脈血栓塞栓症は、急性期死亡率が極めて高いため迅速で的確な診断と治療が不可欠である。治療として抗凝固療法、血栓溶解療法、外科的血栓摘除術が選択されてきたが十分な成果を得ているとは言えない。IVR(画像下治療)が注目されている。カテーテルからの新しい治療法で、我々のハイブリッドIVR治療はその完成形である。臨床応用に至り、成果を上げられれば重症患者の救命率の向上に大きな役割を果たす。

Research Products

• [Journal Article] Late clinical outcome of hybrid catheter intervention for acute massive pulmonary thromboembolism (2020)
  • Author(s): Hiroyuki Tajima, Tatsuo Ueda, Takahiro Mine,Shiro Onozawa, Satoru Murata, Ken Nakazawa
  • Journal Title: Interventional Radiology Volume: ー
  • NAID: 130007867103
  • Peer Reviewed
• [Journal Article] Multicenter investigation of the incidence of inferior vena cava filter fracture (2018)
  • Author(s): J Koizumi,T Hara, T Sekiguchi, T Ichikawa, H Tajima, N Takenoshita, M Tanikake, Y Suyama,T Kaji, K Kato, M Sone, Y Arai, H Anai, K Kichikawa, H Fujieda,T Nishibe, N Yamada, M Nakamura, T Nakano,T Kunieda,T Kuriyama,T Sugimoto,M Takayama, T Kobayashi, S Goto, M Kanazawa, M Itou, K Shirato
  • Journal Title: Japanese Journal of Radiology Volume: 36 Issue: 11 Pages: 661-668
  • DOI: 10.1007/s11604-018-0764-x
  • NAID: 50013030587
  • Peer Reviewed
• [Journal Article] 肺血栓塞栓症および深部静脈血栓症の診断、治療、予防に関するガイドライン(2017年改訂版). (2018)
  • Author(s): 田島廣之、竹之下尚子、金城忠志
  • Journal Title: 救急医学臨時増刊号 Volume: 42 Pages: 1271-1278
• [Journal Article] 手技詳説―血管IVR-胸部.急性肺血栓塞栓症. (2018)
  • Author(s): 中澤賢、田島廣之
  • Journal Title: 臨床放射線 Volume: 63 Pages: 1400-1403
• [Journal Article] Endovenous Treatment for Acute Massive Pulmonary Thromboembolism (2017)
  • Author(s): Tajima H, Kaneshiro T, Takenoshita N, Ichikawa T, Isshiki S, Murata S, Onozawa S, Nakazawa K.
  • Journal Title: Annals of Vascular Diseases Volume: 10 Issue: 4 Pages: 338-344
  • DOI: 10.3400/avd.ra.17-00082
  • NAID: 130006282017
  • ISSN: 1881-641X, 1881-6428
  • Peer Reviewed / Open Access
• [Journal Article] 静脈疾患の検査.血管造影. (2017)
  • Author(s): 金城忠志、竹之下尚子、田島廣之
  • Journal Title: 日本臨床増刊号 Volume: 75 Pages: 213-217
• [Journal Article] カテーテル治療の効果とテクニック (2016)
  • Author(s): 山本剛、田島廣之
  • Journal Title: Heart View Volume: 20 Pages: 73-78
• [Journal Article] 特集 静脈血栓塞栓症（ＶＴＥ）．急性肺血栓塞栓症のＩＶＲ（画像下治療）． (2016)
  • Author(s): 田島廣之、金城忠志、竹ノ下尚子、市川太郎、一色彩子、菊池有史、佐藤直樹、村田智、小野澤志郎、三樹いずみ、山本剛、中沢賢
  • Journal Title: 血管外科（Metropolitan Vascular and Endovascular Surgery）－血管外科症例検討会雑誌－ Volume: 35 Pages: 24-30
• [Presentation] IVR(画像下治療)の進歩と発展 (2020)
  • Author(s): 田島廣之
  • Organizer: 日本医科大学定年退職者講演会
  • Invited
• [Presentation] 静脈血栓塞栓症に対するカテーテル的治療と下大静脈フィルター (2019)
  • Author(s): 1.田島廣之、竹ノ下尚子、金城忠志、川俣博志
  • Organizer: 第39回日本静脈学会総会
  • Invited
• [Presentation] 下大静脈フィルター使用/回収状況は変化したか？ (2019)
  • Author(s): 2.竹ノ下尚子、田島廣之、金城忠志、川俣博志、一色彩子、中摩健二、石原嗣郎
  • Organizer: 第39回日本静脈学会総会
  • Invited
• [Presentation] 血管病変の画像診断と治療―静脈血栓塞栓症を中心にー (2019)
  • Author(s): 田島廣之、竹ノ下尚子、金城忠志、川俣博志
  • Organizer: 第30回末梢血管画像・血管内治療研究会
  • Invited
• [Presentation] Late clinical outcome of manual aspiration thrombectomy and hybrid catheter intervention for life-threatening acute massive pulmonary thromboembolism (2019)
  • Author(s): H. Tajima, T. Kaneshiro, N. Takenoshita, H Kawamata1, T. Ueda, S. Onozawa, S. Murata, N. Tajima
  • Organizer: CIRSE 2019
  • Invited
• [Presentation] 静脈血栓塞栓症ガイドライン2017年改訂版について (2019)
  • Author(s): 田島廣之
  • Organizer: 比企地区抗凝固療法検討会
  • Invited
• [Presentation] Present Status and Clinical Assessment of Interventional Radiology for the Treatment of Acute Massive Pulmonary Thromboembolism. (2018)
  • Author(s): Hiroyuki Tajima, Tadashi Kaneshiro,Naoko Takenoshita, Hiroshi Kawamata, Aya Yamane,Akifumi Kitsuwa, Saiko Isshiki, Taro Ichikawa,Tatsuo Ueda, Daisuke Yasui, Takahiko Mine,Shiro Onozawa, Satoru Murata, Ken Nakazawa
  • Organizer: The 47th Annual Meeting of the Japanese Society of Interventional Radiology and the 13th International Symposium of Interventional Radiology
  • Int'l Joint Research / Invited
• [Presentation] Clinical Assessment of Interventional Radiology for the Treatment of Acute Venous Thromboembolism. (2018)
  • Author(s): Hiroyuki Tajima, Tadashi Kaneshiro, Naoko Takenoshita, Aya Yamane, Akifumi Kitsuwa, Saiko Isshiki, Taro Ichikawa, Tatsuo Ueda, Daisuke Yasui, Hidemasa Saito, Izumi Tanaka, Shiro Onozawa, Satoru Murata
  • Organizer: Progress in Radiology 2018
  • Int'l Joint Research / Invited
• [Presentation] 静脈血栓塞栓症における治療の進歩―特にＩＶＲについてー (2018)
  • Author(s): 田島廣之
  • Organizer: 川崎市放射線医会講演会
  • Invited
• [Presentation] 肺血栓塞栓症と深部静脈血栓症「肺血栓塞栓症の画像診断」 (2017)
  • Author(s): 田島廣之、金城忠志、竹ノ下尚子、一色彩子、市川太郎、佐藤直樹
  • Organizer: 第４４回日本集中治療医学会学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2017-03-09
  • Invited
• [Presentation] Clinical assessment of interventional radiology for acute massive pulmonary embolism (2017)
  • Author(s): H Tajima, N Takenoshita, T Kaneshiro
  • Organizer: APSCVIR 2018
  • Int'l Joint Research / Invited
• [Presentation] Management of acute ilio-femoral DVT (2017)
  • Author(s): H Tajima, N Takenoshita, T Kaneshiro
  • Organizer: APSCVIR 2018
  • Int'l Joint Research / Invited
• [Presentation] 急性肺血栓塞栓症に対するカテーテル治療の実際 (2017)
  • Author(s): 田島廣之
  • Organizer: 第37回日本静脈学会総会
  • Invited
• [Presentation] Late clinical outcome of hybrid catheter intervention for acute massive pulmonary thromboembolism. (2017)
  • Author(s): ．H. Tajima, T. Kaneshiro, N. Takenoshita, I. Miki, T. Ueda, S. Onozawa, S. Murata, N. Tajima
  • Organizer: CIRSE 2017
  • Int'l Joint Research
• [Presentation] 重症急性肺血栓塞栓症に対するＩＶＲ（画像下治療）の治療成績とその評価． (2016)
  • Author(s): 田島廣之、金城忠志、竹ノ下尚子、三樹いずみ、上田達夫、村田智、小野澤志郎、山本剛
  • Organizer: 第３６回日本静脈学会総会
  • Place of Presentation: 弘前
  • Year and Date: 2016-06-23
  • Invited
• [Presentation] Interventional Radiology for the Treatment of Acute Massive Pulmonary Thromboembolism (2016)
  • Author(s): H Tajima, T Kaneshiro, N Takenoshita
  • Organizer: APCCVIR
  • Place of Presentation: Suzhou
  • Year and Date: 2016-04-21
  • Int'l Joint Research / Invited
• [Presentation] Interventional Radiology for the Treatment of Deep Vein Thrombosis (2016)
  • Author(s): H Tajima, T Kaneshiro, N Takenoshita
  • Organizer: APCCVIR
  • Place of Presentation: Suzhou
  • Year and Date: 2016-04-21
  • Int'l Joint Research / Invited
• [Presentation] Diagnostic and Interventional Radiology of Venous Thromboembolism (2016)
  • Author(s): H Tajima
  • Organizer: The 75th Annual Meeting of the Japan Radiological Society
  • Place of Presentation: Yokohama
  • Year and Date: 2016-04-14
  • Int'l Joint Research / Invited
• [Presentation] 静脈血栓塞栓症に対するＩＶＲ（画像下治療）の実際 (2016)
  • Author(s): 田島廣之
  • Organizer: 第３３回飛鳥放射線医学セミナー
  • Place of Presentation: 奈良
  • Invited
• [Book] 新臨床静脈学 (2019)
  • Author(s): 田島廣之、竹ノ下尚子、金城忠志
  • Publisher: メジカルビュー社
• [Book] 血栓循環器学Q&A (2019)
  • Author(s): 編集 伊藤浩
  • Total Pages: 156
  • Publisher: 文光堂
  • ISBN: 9784830619472