Hybrid intervention for severe venous thromboembolism with stent-filter
| Project/Area Number |
16K10365
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2020-03-31
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| Project Status |
Completed (Fiscal Year 2019)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 静脈血栓塞栓症 / Intervention / Interventional Radiology / Thrombectomy / Aspiration / Interventiona Radiology / 放射線 / 循環器・高血圧 / 臨床 |
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| Outline of Final Research Achievements |
The purpose of this research was to make a hybrid interventional therapy for severe venous thromboembolism with a newly-developed stent-filter. Development and fundamental research was achieved, but animal experiment was failed and difficult to move on to the clinical process. On the other hand, we retrospectively analyzed the late outcomes of hybrid catheter intervention, and showed that the 10-year survival rate was 74.5±9.0 %, by Kaplan-Mayer survival analysis, which was comparable with surgical embolectomy.
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| Academic Significance and Societal Importance of the Research Achievements |
重症静脈血栓塞栓症は、急性期死亡率が極めて高いため迅速で的確な診断と治療が不可欠である。治療として抗凝固療法、血栓溶解療法、外科的血栓摘除術が選択されてきたが十分な成果を得ているとは言えない。IVR(画像下治療)が注目されている。カテーテルからの新しい治療法で、我々のハイブリッドIVR治療はその完成形である。臨床応用に至り、成果を上げられれば重症患者の救命率の向上に大きな役割を果たす。
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Report
(5 results)
Research Products
(29 results)
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[Journal Article] Multicenter investigation of the incidence of inferior vena cava filter fracture2018
Author(s)
J Koizumi,T Hara, T Sekiguchi, T Ichikawa, H Tajima, N Takenoshita, M Tanikake, Y Suyama,T Kaji, K Kato, M Sone, Y Arai, H Anai, K Kichikawa, H Fujieda,T Nishibe, N Yamada, M Nakamura, T Nakano,T Kunieda,T Kuriyama,T Sugimoto,M Takayama, T Kobayashi, S Goto, M Kanazawa, M Itou, K Shirato
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Journal Title
Japanese Journal of Radiology
Volume: 36
Issue: 11
Pages: 661-668
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] Present Status and Clinical Assessment of Interventional Radiology for the Treatment of Acute Massive Pulmonary Thromboembolism.2018
Author(s)
Hiroyuki Tajima, Tadashi Kaneshiro,Naoko Takenoshita, Hiroshi Kawamata, Aya Yamane,Akifumi Kitsuwa, Saiko Isshiki, Taro Ichikawa,Tatsuo Ueda, Daisuke Yasui, Takahiko Mine,Shiro Onozawa, Satoru Murata, Ken Nakazawa
Organizer
The 47th Annual Meeting of the Japanese Society of Interventional Radiology and the 13th International Symposium of Interventional Radiology
Related Report
Int'l Joint Research / Invited
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[Presentation] Clinical Assessment of Interventional Radiology for the Treatment of Acute Venous Thromboembolism.2018
Author(s)
Hiroyuki Tajima, Tadashi Kaneshiro, Naoko Takenoshita, Aya Yamane, Akifumi Kitsuwa, Saiko Isshiki, Taro Ichikawa, Tatsuo Ueda, Daisuke Yasui, Hidemasa Saito, Izumi Tanaka, Shiro Onozawa, Satoru Murata
Organizer
Progress in Radiology 2018
Related Report
Int'l Joint Research / Invited
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