Novel production of Cu-67 for cancer therapy using fast neutrons generated by the irradiation of deuterons
| Project/Area Number |
16K10374
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
HASHIMOTO Kazuyuki 国立研究開発法人量子科学技術研究開発機構, 高崎量子応用研究所 東海量子ビーム応用研究センター, 上席研究員(定常) (80414530)
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| Co-Investigator(Kenkyū-buntansha) |
飯田 靖彦 鈴鹿医療科学大学, 薬学部, 教授 (60252425)
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| Research Collaborator |
NAGAI Yasuki
TSUKADA Kazuaki
SUGO Yumi
KAWABATA Masako
SAEKI Hideya
OHTA Akio
MOTOISHI Shoji
SATO Shunichi
FUJISAWA Yutaka
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | RI製造 / 加速器 / 中性子 / がん治療 / 銅67 / 核医学 / 無機工業化学 / 量子ビーム / 癌 / 薬学 |
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| Outline of Final Research Achievements |
Copper-67 is an attractive radionuclide for cancer therapy, because of emissions of medium energy beta particle and gamma rays suitable for imaging. However, the use of Cu-67 in clinical research has been limited due to the difficulty in obtaining a sufficient amount of Cu-67. In this study, we have investigated the production of Cu-67 by the Zn-68(n,x)Cu-67 (x=n’p or d)reaction using fast neutrons from the nat-Be(d,n) or nat-C(d,n) reaction. The highly-purified Cu-67 was obtained from an irradiated Zn-68 oxide sample by the combination of dry thermochromatography and three wet column chromatography (cation exchange resin, chelate resin and anion exchange resin). Furthermore, it was estimated that the specific radioactivity of Cu-67 produced with an accelerator capable of 40 MeV, 2 mA deuteron beams is quite higher than that produced so far with a proton beams.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究成果の学術的意義は、新しい放射性同位元素（RI）製造法である加速器中性子を利用した基礎研究の成果を踏まえ、量及び質、共に臨床応用に応えられる実用レベルのCu-67製造法システムの基盤技術を確立させた点にある。
Cu-67製造・分離システムの基盤技術の確立により、Cu-67の実用化及び国産化へ一歩近づいたと言える。今後、加速器の整備等を図ることにより研究に必要なCu-67の製造を可能にし、Cu-67を用いた放射性薬剤開発の速やかな進展に大きく寄与するとともに、医療用RI医薬品の多くが海外で開発されてきた中で、国産初の新規治療用放射性医薬品の開発に資する。
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Report
(4 results)
Research Products
(8 results)
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[Presentation] Quality control tests of 99mTc-radiopharmacuticals, biodistribution of 67CuCl2 in mice, and accelerator neutrons2018
Author(s)
Yasuki Nagai, Kazuyuki Hashimoto, Masako Kawabata, Kazuaki Tsukada, Yuichi Hatsukawa, Yumi Sugo, Yuto Nakahara, Hideya Saeki, Shoji Motoishi
Organizer
Annual Meeting of Society of Nuclear Medicine and Molecular Imaging (SNMMI 2018), [Philadelphia, USA]
Related Report
Int'l Joint Research
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