Development of optimal radiotherapy protocols for cervical cancer patients with highly precise radiotherapy
| Project/Area Number |
16K10398
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
Toita Takafumi 琉球大学, 医学(系)研究科(研究院), 客員教授 (30237036)
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| Co-Investigator(Kenkyū-buntansha) |
垣花 泰政 琉球大学, 医学(系)研究科(研究院), 助教 (20185713)
有賀 拓郎 琉球大学, 医学部附属病院, 特命講師 (60647337)
前本 均 琉球大学, 医学部附属病院, 医員 (70774470)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 子宮頸癌 / 根治的放射線治療 / 中央遮蔽 / 画像誘導小線源治療 / 前向き臨床試験 / 腔内照射 / 放射線治療 / 高精度放射線治療 / 臨床試験 |
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| Outline of Final Research Achievements |
We investigated interfraction uterine motion using treatment planning CT and cone beam CT (CBCT) to determined the predictive factors affecting uterine movement during external beam RT for patients with cervical cancer treated with definitive RT. We evaluated the oncologic outcomes and complications of cervical cancer patients in terms of CT-based 3D-image-guided brachytherapy parameters. We performed national survey and demonstrated present status of 3D-IGBT for cervical cancer in Japan. We achieved final results of a prospective clinical study of definitive RT consisting of 3D-CRT with no CS and 3D-IGBT for 40 patients with cervical cancer.
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| Academic Significance and Societal Importance of the Research Achievements |
子宮頸癌への強度変調放射線治療（IMRT）適用に支障と考えられた治療中の子宮（ターゲット）移動の詳細を明らかにした。3次元計画腔内照射（3D-IGBT）の適用で中央遮蔽なしの外部照射が日本人でも実施可能なこと、グローバルより低い線量スケジュールで同等の効果を得ること、のエビデンスを臨床試験で得た。3D-IGBT（タンデムとオボイド）の問題点が示され、組織内照射を加えたHybrid-3IGBTの必要性が示唆された。以上の結果は、IMRTと3D-IGBT（Hybrid）を組み合わせた高精度放射線治療の臨床試験の立案に生かされ、今後更に安全で効果の高い子宮頸癌根治照射の開発に寄与すると考えられる。
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] A multi-institutional observational study on the effects of three-dimensional radiotherapy and weekly 40-mg/m2 cisplatin on postoperative uterine cervical cancer patients with high-risk prognostic factors.2019
Author(s)
Isohashi F, Takano T, Onuki M, Arimoto T, Kawamura N, Hara R, Kawano Y, Ota Y, Inokuchi H, Shinjo H, Saito T, Fujiwara S, Sawasaki T, Ando K, Horie K, Okamoto H, Murakami N, Hasumi Y, Kasamatsu T, Toita T.
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Journal Title
Int J Clin Oncol.
Volume: 24
Issue: 5
Pages: 575-582
DOI
Related Report
Peer Reviewed
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[Journal Article] Appropriate radiation dose for symptomatic relief and local control in patients with adult T cell leukemia/lymphoma.2019
Author(s)
Maemoto H, Ariga T, Nakachi S, Toita T, Hashimoto S, Heianna J, Shiina H, Kusada T, Makino W, Kakinohana Y, Miyagi T, Yamamoto Y, Morishima S, Masuzaki H, Murayama S.
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Journal Title
J Radiat Res
Volume: 60
Issue: 1
Pages: 98-108
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Recommendations for high-risk clinical target volume definition with computed tomography for three-dimensional image-guided brachytherapy in cervical cancer patients2016
Author(s)
Tatsuya Ohno, Masaru Wakatsuki, Takafumi Toita, Yuko Kaneyasu, Ken Yoshida, Shingo Kato, Noriko Ii, Sunao Tokumaru, Hitoshi Ikushima, Takashi Uno, Shin-ei Noda, Tomoko Kazumoto, Yoko Harima
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Journal Title
J Radiat Res
Volume: 56
Issue: 3
Pages: 1-10
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Phase II study of concurrent chemoradiotherapy with weekly cisplatin and paclitaxel in patients with locally advanced uterine cervical cancer: The JACCRO GY-01 trial.2016
Author(s)
Umayahara K, Takekuma M, Hirashima Y, Noda SE, Ohno T, Miyagi E, Hirahara F, Hirata E, Kondo E, Tabata T, Nagai Y, Aoki Y, Wakatsuki M, Takeuchi M, Toita T, Takeshima N, Takizawa K.
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Journal Title
Gynecol Oncol.
Volume: 140
Issue: 2
Pages: 253-258
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Proposed definition of the vaginal cuff and paracolpium clinical target volume in postoperative uterine cervical cancer.2016
Author(s)
Murakami N, Norihisa Y, Isohashi F, Murofushi K, Ariga T, Kato T, Inaba K, Okamoto H, Ito Y, Toita T, Itami J.
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Journal Title
Pract Radiat Oncol.
Volume: 6
Issue: 1
Pages: 5-11
DOI
Related Report
Peer Reviewed
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