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Development of optimal radiotherapy protocols for cervical cancer patients with highly precise radiotherapy

Research Project

Project/Area Number 16K10398
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Radiation science
Research InstitutionUniversity of the Ryukyus

Principal Investigator

Toita Takafumi  琉球大学, 医学(系)研究科(研究院), 客員教授 (30237036)

Co-Investigator(Kenkyū-buntansha) 垣花 泰政  琉球大学, 医学(系)研究科(研究院), 助教 (20185713)
有賀 拓郎  琉球大学, 医学部附属病院, 特命講師 (60647337)
前本 均  琉球大学, 医学部附属病院, 医員 (70774470)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords子宮頸癌 / 根治的放射線治療 / 中央遮蔽 / 画像誘導小線源治療 / 前向き臨床試験 / 腔内照射 / 放射線治療 / 高精度放射線治療 / 臨床試験
Outline of Final Research Achievements

We investigated interfraction uterine motion using treatment planning CT and cone beam CT (CBCT) to determined the predictive factors affecting uterine movement during external beam RT for patients with cervical cancer treated with definitive RT. We evaluated the oncologic outcomes and complications of cervical cancer patients in terms of CT-based 3D-image-guided brachytherapy parameters. We performed national survey and demonstrated present status of 3D-IGBT for cervical cancer in Japan. We achieved final results of a prospective clinical study of definitive RT consisting of 3D-CRT with no CS and 3D-IGBT for 40 patients with cervical cancer.

Academic Significance and Societal Importance of the Research Achievements

子宮頸癌への強度変調放射線治療(IMRT)適用に支障と考えられた治療中の子宮(ターゲット)移動の詳細を明らかにした。3次元計画腔内照射(3D-IGBT)の適用で中央遮蔽なしの外部照射が日本人でも実施可能なこと、グローバルより低い線量スケジュールで同等の効果を得ること、のエビデンスを臨床試験で得た。3D-IGBT(タンデムとオボイド)の問題点が示され、組織内照射を加えたHybrid-3IGBTの必要性が示唆された。以上の結果は、IMRTと3D-IGBT(Hybrid)を組み合わせた高精度放射線治療の臨床試験の立案に生かされ、今後更に安全で効果の高い子宮頸癌根治照射の開発に寄与すると考えられる。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (31 results)

All 2019 2018 2017 2016

All Journal Article (14 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 13 results,  Open Access: 7 results,  Acknowledgement Compliant: 2 results) Presentation (14 results) (of which Int'l Joint Research: 1 results,  Invited: 12 results) Book (3 results)

  • [Journal Article] A multi-institutional observational study on the effects of three-dimensional radiotherapy and weekly 40-mg/m2 cisplatin on postoperative uterine cervical cancer patients with high-risk prognostic factors.2019

    • Author(s)
      Isohashi F, Takano T, Onuki M, Arimoto T, Kawamura N, Hara R, Kawano Y, Ota Y, Inokuchi H, Shinjo H, Saito T, Fujiwara S, Sawasaki T, Ando K, Horie K, Okamoto H, Murakami N, Hasumi Y, Kasamatsu T, Toita T.
    • Journal Title

      Int J Clin Oncol.

      Volume: 24 Issue: 5 Pages: 575-582

    • DOI

      10.1007/s10147-018-01380-z

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Appropriate radiation dose for symptomatic relief and local control in patients with adult T cell leukemia/lymphoma.2019

    • Author(s)
      Maemoto H, Ariga T, Nakachi S, Toita T, Hashimoto S, Heianna J, Shiina H, Kusada T, Makino W, Kakinohana Y, Miyagi T, Yamamoto Y, Morishima S, Masuzaki H, Murayama S.
    • Journal Title

      J Radiat Res

      Volume: 60 Issue: 1 Pages: 98-108

    • DOI

      10.1093/jrr/rry068

    • NAID

      120006845629

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] National survey of intracavitary brachytherapy for intact uterine cervical cancer in Japan.2018

    • Author(s)
      Toita T, Ohno T, Ikushima H, Nishimura T, Uno T, Ogawa K, Onishi H, Dokiya T, Itami J; Working Group of the Japanese Group of Brachytherapy/Japan Society for Radiation Oncology (JGB/JASTRO).
    • Journal Title

      J Radiat Res.

      Volume: 59 Issue: 4 Pages: 469-476

    • DOI

      10.1093/jrr/rry035

    • NAID

      120006959732

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Positional uncertainty of vaginal cuff and feasibility of implementing portable bladder scanner in postoperative cervical cancer patients2018

    • Author(s)
      Okamoto Hiroyuki、Murakami Naoya、Carvajal C. Claudia、Miura Yuki、Wakita Akihisa、Nakamura Satoshi、Nishioka Shie、Iijima Kotaro、Inaba Koji、Ito Yoshinori、Kato Tomoyasu、Toita Takafumi、Itami Jun
    • Journal Title

      Phys Med

      Volume: 45 Pages: 1-5

    • DOI

      10.1016/j.ejmp.2017.11.018

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] National survey of intracavitary brachytherapy for intact uterine cervical cancer in Japan.2018

    • Author(s)
      Takafumi Toita, Tatsuya Ohno, Hitoshi Ikushima, Tetsuo Nishimura, Takashi Uno, Kazuhiko Ogawa, Hiroshi Onishi, Takushi Dokiya, Jun Itami; The Working Group of the Japanese Group of Brachytherapy/Japan Society for Radiation Oncology (JGB/JASTRO)
    • Journal Title

      J Radiat Res

      Volume: in press

    • NAID

      120006959732

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Radiotherapy for vaginal cancer: a multi-institutional survey study of the Japanese Radiation Oncology Study Group2017

    • Author(s)
      Ikushima Hitoshi、Wakatsuki Masaru、Ariga Takuro、Kaneyasu Yuko、Tokumaru Sunao、Isohashi Fumiaki、Ii Noriko、Uno Takashi、Ohno Tatsuya、Arisawa Kokichi、Toita Takafumi
    • Journal Title

      Int J Clin Oncol

      Volume: 23 Issue: 2 Pages: 314-320

    • DOI

      10.1007/s10147-017-1205-z

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Concurrent weekly cisplatin versus triweekly cisplatin with radiotherapy for locally advanced squamous-cell carcinoma of the cervix: a retrospective analysis from a single institution2017

    • Author(s)
      Kinjyo Yoshino、Nagai Yutaka、Toita Takafumi、Kudaka Wataru、Ariga Takuro、Shimoji Yuko、Nakasone Tadaharu、Taira Yusuke、Arakaki Yoshihisa、Nakamoto Tomoko、Wakayama Akihiko、Ooyama Takuma、Maemoto Hitoshi、Heianna Joichi、Aoki Yoichi
    • Journal Title

      Br J Radiol

      Volume: 90 Issue: 1076 Pages: 20170241-20170241

    • DOI

      10.1259/bjr.20170241

    • NAID

      120006847308

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Computed tomography?based image-guided brachytherapy for cervical cancer: correlations between dose?volume parameters and clinical outcomes2017

    • Author(s)
      Kusada Takeaki、Toita Takafumi、Ariga Takuro、Maemoto Hitoshi、Hashimoto Seiji、Shiina Hideki、Kakinohana Yasumasa、Heianna Joichi、Nagai Yutaka、Kudaka Wataru、Aoki Yoichi、Murayama Sadayuki
    • Journal Title

      J Radiat Res

      Volume: 59 Issue: 1 Pages: 67-76

    • DOI

      10.1093/jrr/rrx065

    • NAID

      120006845628

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 進行・再発子宮頸癌に対する放射線治療の役割2017

    • Author(s)
      戸板孝文、有賀拓郎、草田武朗、前本均、椎名秀樹、平安名常一、垣花泰政、橋本成司、村山貞之、久高亘、青木陽一
    • Journal Title

      臨床放射線

      Volume: 62 Pages: 1647-1652

    • Related Report
      2017 Research-status Report
  • [Journal Article] Recommendations for high-risk clinical target volume definition with computed tomography for three-dimensional image-guided brachytherapy in cervical cancer patients2016

    • Author(s)
      Tatsuya Ohno, Masaru Wakatsuki, Takafumi Toita, Yuko Kaneyasu, Ken Yoshida, Shingo Kato, Noriko Ii, Sunao Tokumaru, Hitoshi Ikushima, Takashi Uno, Shin-ei Noda, Tomoko Kazumoto, Yoko Harima
    • Journal Title

      J Radiat Res

      Volume: 56 Issue: 3 Pages: 1-10

    • DOI

      10.1093/jrr/rrw109

    • NAID

      120006959731

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Predictive factors of uterine movement during definitive radiotherapy for cervical cancer.2016

    • Author(s)
      Maemoto H, Toita T, Ariga T, Heianna J, Yamashiro T, Murayama S.
    • Journal Title

      J Radiat Res

      Volume: 2016 Issue: 3 Pages: 1-5

    • DOI

      10.1093/jrr/rrw101

    • NAID

      120006847256

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Phase II study of concurrent chemoradiotherapy with weekly cisplatin and paclitaxel in patients with locally advanced uterine cervical cancer: The JACCRO GY-01 trial.2016

    • Author(s)
      Umayahara K, Takekuma M, Hirashima Y, Noda SE, Ohno T, Miyagi E, Hirahara F, Hirata E, Kondo E, Tabata T, Nagai Y, Aoki Y, Wakatsuki M, Takeuchi M, Toita T, Takeshima N, Takizawa K.
    • Journal Title

      Gynecol Oncol.

      Volume: 140 Issue: 2 Pages: 253-258

    • DOI

      10.1016/j.ygyno.2015.12.008

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Proposed definition of the vaginal cuff and paracolpium clinical target volume in postoperative uterine cervical cancer.2016

    • Author(s)
      Murakami N, Norihisa Y, Isohashi F, Murofushi K, Ariga T, Kato T, Inaba K, Okamoto H, Ito Y, Toita T, Itami J.
    • Journal Title

      Pract Radiat Oncol.

      Volume: 6 Issue: 1 Pages: 5-11

    • DOI

      10.1016/j.prro.2015.04.008

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic Factors and Treatment Outcome for Patients with Stage IVB Cervical Cancer.2016

    • Author(s)
      Oishi S, Kudaka W, Toita T, Ariga T, Nakamoto T, Wakayama A, Nagai Y, Kaneshima I, Nishihira K, Aoki Y.
    • Journal Title

      Anticancer Res.

      Volume: 36 Pages: 3471-5

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 婦人科がんにおける放射線治療の役割2018

    • Author(s)
      戸板孝文
    • Organizer
      日本産科婦人科学会第70回学術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 子宮頸がんの放射線治療 臨床における位置づけと現状、そしてこれからの課題2018

    • Author(s)
      戸板孝文
    • Organizer
      第136回放射線治療かたろう会一泊研修
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 婦人科がんに対する小線源治療の安定供給と医療制度面の問題.2018

    • Author(s)
      戸板孝文
    • Organizer
      日本放射線腫瘍学会小線源治療部会第20回学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 子宮頸癌のCTV delineation2018

    • Author(s)
      戸板孝文
    • Organizer
      JCRミッドサマーセミナー2018
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 婦人科腫瘍における化学放射線療法2018

    • Author(s)
      戸板孝文
    • Organizer
      第60回日本婦人科腫瘍学会学術講演会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 島嶼県沖縄の放射線治療―現状と課題―2018

    • Author(s)
      戸板孝文
    • Organizer
      日本放射線腫瘍学会第31回学術大会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 研修医セミナー 最近の放射線治療の進歩2017

    • Author(s)
      戸板孝文
    • Organizer
      第76回日本医学放射線学会総会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 婦人科腫瘍に対する放射線治療: 高精度放射線治療の現状と課題. 合同企画III: 日本放射線腫瘍学会: 婦人科腫瘍に対する高精度放射線治療の現状と今後の展望.2017

    • Author(s)
      戸板孝文
    • Organizer
      第59回日本婦人科腫瘍学会学術講演会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 子宮頸癌の放射線治療 高い根治性と安全性の両立を目指して. シンポジウム4. 「それぞれの癌」:がん治療にまつわるUpdate 放射線治療は根治を目指す-2017

    • Author(s)
      戸板孝文
    • Organizer
      第55回日本癌治療学会学術集会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] 子宮頸癌広汎子宮全摘出術後:放射線療法 vs 化学療法. 放射線治療の立場から. クリニカルディベート2016

    • Author(s)
      戸板孝文
    • Organizer
      第13回日本婦人科がん会議
    • Place of Presentation
      伊勢志摩観光ホテル(三重県志摩市)
    • Year and Date
      2016-09-30
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Clinical roles and perspectives of radiotherapy for cervical cancer. 特別講演2016

    • Author(s)
      戸板孝文
    • Organizer
      第112回日本医学物理学会学術大会
    • Place of Presentation
      沖縄コンベンションセンター(沖縄県宜野湾市)
    • Year and Date
      2016-09-09
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] 子宮頸癌腔内照射:2D治療計画から3D治療計画の移行期における多施設臨床試験デザイン上の問題点. シンポジウム Brachytherapyの多施設研究の問題点2016

    • Author(s)
      戸板孝文
    • Organizer
      第18回日本放射線腫瘍学会小線源治療部会学術大会
    • Place of Presentation
      ホテルエルセラーン大阪(大阪府大阪市)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Research-status Report
    • Invited
  • [Presentation] Predictive factors for inter-fraction uterine motion in definitive radiotherapy for cervical cancer.2016

    • Author(s)
      Maemoto H, Toita T, et al..
    • Organizer
      ESTRO35
    • Place of Presentation
      Turin, Italy
    • Year and Date
      2016-04-30
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Quantification of uterine motion during a course of definitive radiotherapy2016

    • Author(s)
      前本均、戸板孝文、他
    • Organizer
      第75回日本医放射線学会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Research-status Report
  • [Book] 子宮頸・子宮体・卵巣・腟・外陰. 編集:井上俊彦、小川和彦、小泉雅彦. 放射線治療学. 改訂6版2017

    • Author(s)
      戸板孝文
    • Total Pages
      439
    • Publisher
      南山堂
    • Related Report
      2017 Research-status Report
  • [Book] 子宮頸癌. 第7章各領域の治療. 婦人科腫瘍. 編集:大西洋. がん放射線療法2017. 改訂第7版2017

    • Author(s)
      戸板孝文
    • Total Pages
      1336
    • Publisher
      学研メディカル秀潤社
    • Related Report
      2017 Research-status Report
  • [Book] 放射線治療を受ける患者さんに知っていただきたいこと. 編集:杉山徹. 女性のがんの治療2017

    • Author(s)
      戸板孝文
    • Total Pages
      116
    • Publisher
      ヴァンメディカル
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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