Effect of Clarithromycin on prevention of radiation pneumonitis
| Project/Area Number |
16K10403
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Tokai University |
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Principal Investigator |
TAKEDA Atsuya 東海大学, 医学部, 客員教授 (80296699)
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| Co-Investigator(Kenkyū-buntansha) |
奥 洋平 東海大学, 医学部, 客員講師 (10468473)
秋庭 健志 東海大学, 医学部, 講師 (40276845)
国枝 悦夫 東海大学, 医学部, 教授 (70170008)
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| Project Period (FY) |
2016-04-01 – 2021-03-31
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| Project Status |
Completed (Fiscal Year 2020)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 定位放射線治療 / 放射線肺臓炎 / 障害予防 / クラリスロマイシン / 抗炎症作用 / 放射線治療 / 肺臓炎 / クラリス / 放射線肺臓炎予防 / 体幹部定位放射線治療 / 肺がん / 肺癌 |
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| Outline of Final Research Achievements |
Radiation pneumonitis is a critical pulmonary toxicity after irradiation of the lung. We administered Clarithromycin to patients with high-risk factors for radiation pneumonitis, andThe purposes of this project is to 1: retrospectively investigate whether CAM mitigated radiation pneumonitis following stereotactic body radiotherapy (SBRT), 2: design a prospective study to investigate the efficacy of Clarithromycin on preventing radiation pneumonitis. However, prospective studies were not performed because of the difficulty due to the restriction of the Rinshyo-Kenkyu Low, which is in effect during the study period.
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| Academic Significance and Societal Importance of the Research Achievements |
早期肺癌に対する体幹部定位放射線治療は、手術適応外患者に対する標準治療法とされ、また手術ハイリスク患者においても同等の生存率が報告されており今後さらなる適応拡大が期待される。しかし致死的有害事象もすくなかずあり、そのうち多数は放射線肺臓炎が原因となっている。そのため体幹部定位放射線治療における放射線肺臓炎の予防は重要な課題である。クラリスロマイシンの少量投与をおこなう本研究により放射線肺臓炎高リスク患者に対して体幹部定位放射線治療を行う際に、放射線肺臓炎の頻度減少が期待されれば、特発性肺線維症患者併発早期肺癌患者において根治的治療を行えるチャンスが増えるなど治療パラダイムを変える可能性がある。
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Report
(6 results)
Research Products
(31 results)
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[Journal Article] Stereotactic body radiotherapy for lung cancer patients with idiopathic interstitial pneumonias.2017
Author(s)
Tsurugai Y, Takeda A, Sanuki N, Enomoto T, Kaneko T, Hara Y, Mizuno T, Saeki N, Aoki Y, Oku Y, Akiba T, Kunieda E
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Journal Title
Radiother Oncol.
Volume: 125
Issue: 2
Pages: 310-316
DOI
Related Report
Peer Reviewed
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[Journal Article] Stereotactic body radiotherapy (SBRT) for T3 and T4N0M0 non-small cell lung cancer2016
Author(s)
Eriguchi T, Takeda A, Sanuki N, Nishimura S, Takagawa Y, Enomoto T, Saeki N, Yashiro K, Mizuno T, Aoki Y, Oku Y, Yokosuka T, Shigematsu N
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Journal Title
J Radiat Res
Volume: 57(3)
Issue: 3
Pages: 265-72
DOI
Related Report
Peer Reviewed
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[Presentation] Excellent Survival! Multi-Institutional Study of Stereotactic Body Radiation Therapy for Medically Operable and Young (70 Years Old or Younger) Patients With Stage I Non-Small Cell Lung Cancer.2016
Author(s)
Onishi H, Shioyama Y, Matsumoto Y, Takayama K, Matsuo Y, Miyakawa A, Yamashita H, Matsushita H, Aoki M, Nihei K, Kimura T, Ishiyama H, Murakami, Nakata K, Takeda A, Uno T, Nomiya T, Takanaka T, Seo Y
Organizer
The 58th American Society of Therapeutic Radiation Oncology Annual Meeting
Place of Presentation
USABoston Convention and Exhibition Center（USA Boston）
Year and Date
2016-09-25
Related Report
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