| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The clinical application of carbon ion (C-ion) beams is effective and safety cancer therapy. Because C-ion beams are concentrated to irradiate tumor region. However, this radiotherapy potentially causes adverse reactions. Some of FGF have protective effects against radiation injury. FGF1 is a candidate radioprotector for radiation-induced damage. FGF1/CPP-C chimeric protein was created to enhance the intracellular signaling mode of FGF1 instead of FGFR signaling. The present study investigated the protective effects of FGF1/CPP-C on the intestinal damage by C-ion radiotherapy.
The FGF1/CPP-C treatment promoted crypt survival after C-ion irradiation significantly through inhibition of C-ion-induced apoptosis and downstream signaling pathway of FGFRs, reduction of DSBs of DNA and suppression of the activation of cell-cycle regulatory molecules. These results suggest that the intracellular signaling mode of FGF1/CPP-C attenuates the intestinal adverse effects of C-ion radiotherapy.
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