Fundamental research for accelerator-based boron neutron capture therapy and consideration of the protocol for the clinical trial
Project/Area Number |
16K10410
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Radiation science
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Research Institution | National Cancer Center Japan |
Principal Investigator |
Hiroshi Igaki 国立研究開発法人国立がん研究センター, 中央病院, 医長 (90361344)
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Co-Investigator(Kenkyū-buntansha) |
中村 哲志 国立研究開発法人国立がん研究センター, 中央病院, 医学物理士 (20638374)
伊丹 純 国立研究開発法人国立がん研究センター, 中央病院, 科長 (40505377)
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Project Period (FY) |
2016-04-01 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | ホウ素中性子捕捉療法 / 直線加速器 / リチウムターゲット / 悪性黒色腫 / 血管肉腫 / 臨床試験 / 治験 / 放射線治療 / 中性子 / 加速器 |
Outline of Final Research Achievements |
In this research project, we have prepared for the start of a clinical trial of boron neutron capture therapy (BNCT) using accelerator-based neutron irradiation system installed in the National Cancer Center. The energy spectrum of the neutron beam was measured, and its biological effects were evaluated by cell and animal experiments and the physical data of the energy spectrum of the neutron beam. Based on these funcamental data, the protocol of a clinical trial of BNCT was constructed. In November 2019, we have started the clinical trial of BNCT for skin melanoma and angiosarcoma.
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Academic Significance and Societal Importance of the Research Achievements |
BNCT用の加速器型中性子照射装置は京都大学と住友重機械工業がすでに開発し、治験が終了している。本研究で開発した装置は先行する京都大学/住重製装置とまったく異なる中性子発生メカニズムを有し、新規のBNCT用中性子照射装置開発が促進される。また、発生する中性子エネルギーが格段に低く、装置に付帯する減速体が小型となるため、当院の装置が医療機器として承認されれば、医療従事者の被曝低減に寄与し、BNCT装置の回転ガントリー化とBNCT装置の普及も促進される。さらに、先行装置とは臨床試験の対象疾患が異なるため、BNCTの適応拡大にも寄与し、がん治療モダリティの選択肢拡大に貢献する。
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Report
(5 results)
Research Products
(98 results)
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[Journal Article] 皮膚悪性腫瘍ガイドライン第3版 メラノーマ診療ガイドライン20192019
Author(s)
中村 泰大, 浅井 純, 井垣 浩, 猪爪 隆史, 並川 健二郎, 林 礼人, 福島 聡, 藤村 卓, 伊東 孝通, 今福 惠輔, 田中 亮多, 寺本 由紀子, 皆川 茜, 宮川 卓也, 宮下 梓, 和田 誠, 古賀 弘志, 菅谷 誠
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Journal Title
The Japanese Journal of Dermatology
Volume: 129
Issue: 9
Pages: 1759-1843
DOI
NAID
ISSN
0021-499X, 1346-8146
Year and Date
2019-08-20
Related Report
Peer Reviewed
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[Journal Article] Japanese Dermatological Association Guidelines: Outlines of guidelines for cutaneous melanoma 2019.2019
Author(s)
Nakamura Y, Asai J, Igaki H, Inozume T, Namikawa K, Hayashi A, Fukushima S, Fujimura T, Ito T, Imafuku K, Tanaka R, Teramoto Y, Minagawa A, Miyagawa T, Miyashita A, Wada M, Koga H, Sugaya M.
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Journal Title
J Dermatol.
Volume: 47
Issue: 2
Pages: 89-103
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Dummy-run for standardizing plan quality of intensity-modulated radiotherapy for postoperative uterine cervical cancer: Japan Clinical Oncology Group study (JCOG1402).2019
Author(s)
Okamoto H, Murakami N, Isohashi F, Kasamatsu T, Hasumi Y, Iijima K, Nishioka S, Nakamura S, Nakamura M, Nishio T, Igaki H, Nakayama Y, Itami J, Ishikura S, Nishimura Y, Toita T.
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Journal Title
Radiat Oncol.
Volume: 14
Issue: 1
Pages: 133-133
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical Practice Guidelines for Hepatocellular Carcinoma: The Japan Society of Hepatology 2017 (4th JSH-HCC Guidelines) a 2019 update2019
Author(s)
Kokudo N, Takemura N, Hasegawa K, Takayama T, Kubo S, Shimada M, Nagano H, Hatano E, Izumi N, Kaneko S, Kudo M, Iijima H, Genda T, Tateishi R, Torimura T, Igaki H, Kobayashi S, Sakurai H, Murakami T, Watadani T, Matsuyama Y
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Journal Title
Hepatol Res
Volume: 49(10)
Issue: 10
Pages: 1109-1113
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Hemorrhage from ascending colon and gluteal muscle associated with sorafenib and radiotherapy: Radiation dose distribution corresponded with colonoscopy findings and computed tomography images.2019
Author(s)
Kashihara T, Murakami N, Iizumi S, Sakamoto Y, Nakamura S, Iijima K, Takahashi K, Inaba K, Okuma K, Igaki H, Nakayama Y, Okusaka T, Uno T, and Itami J.
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Journal Title
Practical Radiation Oncology
Volume: In-press
Issue: 4
Pages: 214-219
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Induction chemotherapy with docetaxel, cisplatin and fluorouracil followed by concurrent chemoradiotherapy for unresectable sinonasal undifferentiated carcinoma: Two cases of report.2019
Author(s)
Watanabe S, Honma Y, Murakami N, Igaki H, Mori T, Hirano H, Okita N, Shoji H, Iwasa S, Takashima A, Kato K, Kobayashi K, Matsumoto F, Yoshimoto S, Itami J, Boku N.
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Journal Title
World J Clin Cases.
Volume: 7(6)
Issue: 6
Pages: 765-772
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Hyaluronic gel injection into the vesicovaginal septum for high-dose-rate brachytherapy of uterine cervical cancer: an effective approach for bladder dose reduction.2019
Author(s)
Murakami N, Shima S, Kashihara T, Tselis N, Kato T, Takagawa Y, Masui K, Yoshida K, Takahashi K, Inaba K, Okuma K, Igaki H, Nakayama Y, Itami J.
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Journal Title
J Contemp Brachytherapy
Volume: 11
Issue: 1
Pages: 1-7
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Dependence of neutrons generated by 7Li(p, n) reaction on Li thickness under free-air condition in accelerator-based boron neutron capture therapy system employing solid-state Li target.2019
Author(s)
Nakamura S, Igaki H, Okamoto H, Wakita A, Ito M, Imamichi S, Nishioka S, Iijima K, Nakayama H, Takemori M, Kobayashi K, Abe Y, Okuma K, Takahashi K, Inaba K, Murakami N, Nakayama Y, Nishio T, Masutani M, and Itami J.
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Journal Title
Physica Medica
Volume: 58
Pages: 121-130
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Monte Carlo modeling of a 60Co MRI-guided radiotherapy system on Geant4 and experimental verification of dose calculation under a magnetic field of 0.35 T.2019
Author(s)
Okamoto H, Nishioka S, Iijima K, Nakamura S, Sakasai T, Miura Y, Takemori M, Nakayama H, Morishita Y, Shimizu M, Abe Y, Igaki H, Nakayama Y, and Itami J.
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Journal Title
Journal of Radiation Research
Volume: 60(1)
Issue: 1
Pages: 116-123
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Efforts toward Patient Safety: Development of System and Education of Non-Technical Skill2018
Author(s)
Okamoto H, Nakamura S, Nishioka S, Iijima K, Takemori M, Nakayama H, Aikawa A, Shibata Y, Kato T, Abe Y, Igaki H, Nakayama Y, and Itami J.
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Journal Title
Japanese Journal of Medical Physics (Igakubutsuri)
Volume: 38
Issue: 2
Pages: 62-67
DOI
ISSN
1345-5354, 2186-9634
Year and Date
2018-10-31
Related Report
Peer Reviewed / Open Access
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[Journal Article] Long-term Results of External Beam Radiotherapy for Prostate Cancer with Prostate-specific Antigen of More Than 50 ng/ml and Without Evidence of Lymph Node or Distant Metastasis2018
Author(s)
Umezawa R, Inaba K, Nakamura S, Wakita A, Okamoto H, Shima S, Tsuchida K, Kashihara T, Kobayashi K, Harada K, Takahashi K, Murakami N, Ito Y, Igaki H, Jingu K, Itami J.
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Journal Title
Anticancer Research
Volume: 38
Issue: 4
Pages: 2303-2309
DOI
Related Report
Peer Reviewed
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[Journal Article] Importance of the site of positive surgical margin in salvage external beam radiation therapy for biochemical recurrence of prostate cancer after radical prostatectomy.2018
Author(s)
Kashihara T, Nakamura S, Wakita A, Okamoto H, Inaba K, Umezawa R, Shima S, Tsuchida K, Kobayashi K, Takahashi K, Murakami N, Ito Y, Fujimoto H, Uno T, and Itami J.
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Journal Title
Cancer Medicine
Volume: 7(5)
Issue: 5
Pages: 1273-1730
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Image-guided interstitial high-dose-rate brachytherapy for locally recurrent uterine cervical cancer: A single-institution study.2018
Author(s)
Umezawa R, Murakami N, Nakamura S, Wakita A, Okamoto H, TSuchida K, Kashihara T, Kobayashi K, Harada K, Takahashi K, Inaba K, Ito Y, Igaki H, Masui K, Yoshida K, Jingu K, Tselis N, and Itami J.
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Journal Title
Brachytherapy
Volume: 17(2)
Issue: 2
Pages: 368-376
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] A management method for the statistical results of patient-specific quality assurance for intensity-modulated radiation therapy2017
Author(s)
Nakamura S, Okamoto H, Wakita A, Umezawa R, Takahashi K, Inaba K, Murakami N, Kato T, Igaki H, Ito Y, Abe Y, and Itami J
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Journal Title
Journal of Radiation Research
Volume: 印刷中
Issue: 4
Pages: 572-578
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Evaluation of radioactivity in the bodies of mice induced by neutron exposure from an epi-thermal neutron source of an accelerator-based boron neutron capture therapy system2017
Author(s)
Nakamura S, Imamichi S, Masumoto K, Ito M, Wakita A, Okamoto H, Nishioka S, Iijima K, Kobayashi K, Abe Y, Igaki H, Kurita K, Nishio T, Masutani M, Itami J.
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Journal Title
Proceedings of the Japan Academy, Series B
Volume: 93
Issue: 10
Pages: 821-831
DOI
NAID
ISSN
0386-2208, 1349-2896
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A management method for the statistical results of patient-specific quality assurance for intensity-modulated radiation therapy.2017
Author(s)
Nakamura S, Okamoto H, Wakita A, Umezawa R, Takahashi K, Inaba K, Murakami N, Kato T, Igaki H, Ito Y, Abe Y, Itami J.
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Journal Title
J Radiat Res.
Volume: 印刷中
Related Report
Peer Reviewed
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[Journal Article] Patterns of recurrence after selective postoperative radiation therapy for patients with head and neck squamous cell carcinoma2016
Author(s)
Murakami N, Matsumoto F, Yoshimoto S, Ito Y, Mori T, Ueno T, Tuchida K, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Umezawa R, Takahashi K, Inaba K, Igaki H, Itami J
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Journal Title
BMC Cancer
Volume: 16
Issue: 1
Pages: 192-195
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Salvage High-dose-rate Interstitial Brachytherapy for Pelvic Recurrent Cervical Carcinoma After Hysterectomy.2016
Author(s)
Murakami N, Kato T, Miyamoto Y, Nakamura S, Wakita A, Okamoto H, Tsuchida K, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Takahashi K, Umezawa R, Inaba K, Ito Y, Igaki H, Itami J.
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Journal Title
Anticancer Res.
Volume: 36
Pages: 2413-2421
Related Report
Peer Reviewed
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[Journal Article] After low and high dose-rate interstitial brachytherapy followed by IMRT radiotherapy for intermediate and high risk prostate cancer.2016
Author(s)
Nakamura S, Murakami N, Inaba K, Wakita A, Kobayashi K, Takahashi K, Okamoto H, Umezawa R, Morota M, Sumi M, Igaki H, Ito Y, Itami J.
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Journal Title
BMC Cancer
Volume: 16
Issue: 1
Pages: 296-296
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Dose reconstruction technique using non-rigid registration to evaluate spatial correspondence between high-dose region and late radiation toxicity: a case of tracheobronchial stenosis after external beam radiotherapy combined with endotracheal brachythera.2016
Author(s)
Kobayashi K, Murakami N, Inaba K, Wakita A, Nakamura S, Okamoto H, Sato J, Umezawa R, Takahashi K, Igaki H, Ito Y, Shigematsu N, Itami J
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Journal Title
Journal of Contemporary Brachytherapy
Volume: 8
Pages: 156-63
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Long-term observations of radiation-induced creatinine clearance reduction and renal parenchymal volume atrophy.2016
Author(s)
Inaba K, Okamoto H, Wakita A, Tsuchida K, Kashihara T, Kobayashi K, Harada K, Kitaguchi M, Sekii S, Umezawa R, Takahashi K, Murakami N, Ito Y, Igaki H, Uno T, Itami J.
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Journal Title
Radiother Oncol.
Volume: 120
Issue: 1
Pages: 145-149
DOI
Related Report
Peer Reviewed
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[Journal Article] In vivo spatial correlation between (18)F-BPA and (18)F-FDG uptakes in head and neck cancer.2016
Author(s)
Kobayashi K, Kurihara H, Watanabe Y, Murakami N, Inaba K, Nakamura S, Wakita A, Okamoto H, Umezawa R, Takahashi K, Igaki H, Ito Y, Yoshimoto S, Shigematsu N, Itami J.
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Journal Title
Appl Radiat Isot.
Volume: 115
Pages: 138-146
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Prospective study of postoperative whole breast radiotherapy for Japanese large-breasted women: a clinical and dosimetric comparisons between supine and prone positions and a dose measurement using a breast phantom.2016
Author(s)
Takahashi K, Morota M, Kagami Y, Okamoto H, Sekii S, Inaba K, Murakami N, Igaki H, Ito Y, Uno T, Itami J.
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Journal Title
BMC Cancer.
Volume: 16
Issue: 1
Pages: 757-757
DOI
Related Report
Peer Reviewed
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[Journal Article] The role of interstitial brachytherapy in the management of primary radiation therapy for uterine cervical cancer.2016
Author(s)
Murakami N, Kobayashi K, Kato T, Nakamura S, Wakita A, Okamoto H, Shima S, Tsuchida K, Kashihara T, Harada K, Takahashi K, Umezawa R, Inaba K, Ito Y, Igaki H, Itami J.
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Journal Title
J Contemp Brachytherapy.
Volume: 8
Pages: 391-398
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] MR-guided online adaptive stereotactic body radiotherapy for pancreatic cancer2020
Author(s)
Igaki H, Nishioka S, Sakasai T, Inaba K, Okamoto H, Kuwahara J, Miura Y, Okuma K, Iijima K, Nakayama H, Takemori M, Nakamura S, Kashihara T, Abe Y, Katsuta S, Itami J.
Organizer
Asian ViewRay Users Meeting Tokyo 2020.2.8.
Related Report
Int'l Joint Research
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[Presentation] A clinical trial of lithium-targeted accelerator-based boron neutron capture therapy at National Cancer Center Hospital.2019
Author(s)
Igaki H, Nakamura S, Imamichi S, Nakamura M, Uehara K, Kashihara T, Nishioka S, Iijima K, Goka T, Fujii R, Takahashi K, Inaba K, Okuma K, Murakami N, Nakayama T, Imahori T, Katsuta S, Okamoto H, Abe Y, Masutani M, Itami J.
Organizer
10th young researchers BNCT meeting
Related Report
Int'l Joint Research
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[Presentation] Early clinical experience of magnetic resonance-guided online adaptive stereotactic body radiotherapy for pancreas cancer in Japan.2019
Author(s)
Igaki H, Okamoto H, Sakasai T, Nishioka S, Inaba K, Miura Yuki, Kuwahara J, Okuma K, Nakayama Y, Abe Y, Itami J.
Organizer
ViewRay 2019 Users' Meeting
Related Report
Int'l Joint Research
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[Presentation] Comparison between SUVmax, TNR, and TBR in 18F-BPA PET. Which index is correlated best with 18FDG uptake?2018
Author(s)
Igaki H, Nakamura S, Kurihara H, Abe Y, Uematsu M, Shima S, Kashihara T, Takagawa Y, Iijima K, Nishioka S, Fujii R, Nakamura M, Takahashi K, Inaba K, Murakami N, Okuma K, Nakayama Y, Morita T, Okamoto H, Imahori Y, Itami J.
Organizer
The 18th International Congress on Neutron Capture Therapy
Related Report
Int'l Joint Research
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[Presentation] Whole brain radiotherapy for brain metastases from melanoma in the era of molecular-targeted therapy2016
Author(s)
Hiroshi Igaki, Koji Inaba, Kiyoshi Shima, Keisuke Tsuchida, Kazuma Kobayashi, Ken Harada, Rei Umezawa, Kana Takahashi, Naoya Murakami, Yoshinori Ito, Jun Itami
Organizer
日本放射線腫瘍学会第29回学術大会
Place of Presentation
国立京都国際会館(京都府京都市)
Year and Date
2016-11-25
Related Report
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[Presentation] Time course changes in 18F-BPA uptake dynamics by PET scan.2016
Author(s)
Igaki H, Kurihara H, Nakamura S, Fujii R, Wakita A, Tsuchida K, Kashihara T, Kobayashi K, Harada K, Takahashi K, Inaba K, Umezawa R, Murakami N, Ito Y, Okamoto H, Imahori Y, Itami J.
Organizer
The 17th International Congress on Neutron Capture Therapy
Place of Presentation
Columbia, MO, USA.
Year and Date
2016-10-02
Related Report
Int'l Joint Research
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