Radiobiological analysis for new technological development of proton beam therapy

• Project/Area Number: 16K10412
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Radiation science
• Research Institution: National Cancer Center Japan
• Principal Investigator: Akimoto Tetsuo 国立研究開発法人国立がん研究センター, 先端医療開発センター, 分野長 (10261851)
• Co-Investigator(Kenkyū-buntansha): 茂木 厚 国立研究開発法人国立がん研究センター, 東病院, 医員 (10433997)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 放射線治療 / 放射線生物 / 陽子線治療 / 細胞応答 / ブラッグピーク / 放射線感受性 / 放射線応答 / 陽子線 / 感受性増感 / 拡大ブラッグピーク / 生物学的効果比 （RBE） / ブラックピーク / RBE / DNA損傷修復 / LET

Outline of Final Research Achievements

The main purpose of this research is to analyze the differences in the biological effect of a high-energy proton beam on the target cells placed at different positions on the SOBP, using two human esophageal cancer cell lines with differing radiosensitivities, and to investigate enhancement by chemotherapeutic agents of the sensitivity of cancer cells to proton beam irradiation and clarify the differences in the responses of the chemotherapy-treated cells to proton beam irradiation according to the position of the cells on the SOBP. The results of this research demonstrate that the RBE of a high-energy proton beam and the cellular responses, including the DNA damage repair processes, to high-energy proton beam irradiation, differ according to the position on the SOBP. In addition, the results research showed that the effect of 5-FU in enhancing the effect of proton beam irradiation on cancer cells may be constant for all positions on the SOBP.

Academic Significance and Societal Importance of the Research Achievements

陽子線照射に関する細胞応答の解析は、陽子線照射が可能な施設が世界的に限られていること、生物研究環境が整った施設が少ないことなどから、十分に行われてきたとは言えない。陽子線治療の線量は厳密に日々検証されているが、検証には限界がある。そのため、本研究課題は現状の陽子線治療の物理学的検証の限界を補完する意義を有している。今後の陽子線治療の普及や臨床的な適応拡大を考えると、本研究で明らかにした陽子線治療の3 次元的な空間的照射位置とその生物学的特性の解明は、今後の陽子線治療の臨床応用や臨床試験実施などでも欠かせず、本研究の成果が今後の陽子線治療と化学療法併用の重要な基礎データとなり得ると考えられる。

Research Products

• [Journal Article] Impact of intraoperative indocyanine green fluorescence angiography on anastomotic leakage after laparoscopic sphincter-sparing surgery for malignant rectal tumors. (2020)
  • Author(s): Hasegawa H, Tsukada Y, Wakabayashi M, Nomura S, Sasaki T, Nishizawa Y, Ikeda K, Akimoto T, Ito M.
  • Journal Title: Int J Colorectal Dis. Volume: 35 Issue: 3 Pages: 3-3
  • DOI: 10.1007/s00384-019-03490-0
• [Journal Article] Proton Beam Therapy for Histologically or Clinically Diagnosed Stage I Non-Small Cell Lung Cancer (NSCLC): The First Nationwide Retrospective Study in Japan (2020)
  • Author(s): Ohnishi Kayoko、Nakamura Naoki、Harada Hideyuki、Tokumaru Sunao、Wada Hitoshi、Arimura Takeshi、Iwata Hiromitsu、Sato Yoshitaka、Sekino Yuta、Tamamura Hiroyasu、Mizoe Jun-etsu、Ogino Takashi、Ishikawa Hitoshi、Kikuchi Yasuhito、Okimoto Tomoaki、Murayama Shigeyuki、Akimoto Tetsuo、Sakurai Hideyuki
  • Journal Title: International Journal of Radiation Oncology*Biology*Physics Volume: 106 Issue: 1 Pages: 82-89
  • DOI: 10.1016/j.ijrobp.2019.09.013
  • NAID: 120007132698
  • Peer Reviewed / Open Access
• [Journal Article] Impact of Proton Beam Irradiation of an Anatomic Subsegment of the Liver for Hepatocellular Carcinoma (2019)
  • Author(s): Hojo Hidehiro、Raturi Vijay、Nakamura Naoki、Arahira Satoko、Akita Tsunemichi、Mitsunaga Shuichi、Nakamura Masaki、Motegi Atsushi、Kageyama Shun-ichiro、Zenda Sadamoto、Okumura Masayuki、Ikeda Masafumi、Akimoto Tetsuo
  • Journal Title: Practical Radiation Oncology Volume: S1879-8500 Issue: 4 Pages: 30276-0
  • DOI: 10.1016/j.prro.2019.09.012
• [Journal Article] Nutritional support dependence after curative chemoradiotherapy in head and neck cancer: supplementary analysis of a phase II trial (JCOG0706S1) (2019)
  • Author(s): Imamura Yoshinori、Kiyota Naomi、Ogawa Gakuto、Akimoto Tetsuo、Fujii Masato、Hanai Nobuhiro、Iwae Shigemichi、Monden Nobuya、Matsuura Kazuto、Onozawa Yusuke、Hayashi Ryuichi、Tahara Makoto、Minami Shujiro、Eba Junko、Japan Clinical Oncology Group (JCOG) Head and Neck Cancer Study Group
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 49 Issue: 11 Pages: 1009-1015
  • DOI: 10.1093/jjco/hyz121
• [Journal Article] Phase II feasibility study of preoperative concurrent chemoradiotherapy with cisplatin plus 5-fluorouracil and elective lymph node irradiation for clinical stage II/III esophageal squamous cell carcinoma. (2019)
  • Author(s): Hashimoto J, Kato K, Ito Y, Kojima T, Akimoto T, Daiko H, Hamamoto Y, Matsushita H, Katano S, Hara H, Tanaka Y, Saito Y, Nagashima K, Igaki H.
  • Journal Title: Int J Clin Oncol. Volume: 24 Issue: 1 Pages: 60-67
  • DOI: 10.1007/s10147-018-1336-x
• [Journal Article] Expression of Monocarboxylate Transporter 1 Is Associated With Better Prognosis and Reduced Nodal Metastasis in Pancreatic Ductal Adenocarcinoma (2019)
  • Author(s): Sukeda Aoi、Nakamura Yuka、Nishida Yasunori、Kojima Motohiro、Gotohda Naoto、Akimoto Tetsuo、Ochiai Atsushi
  • Journal Title: Pancreas Volume: 48 Issue: 8 Pages: 1102-1110
  • DOI: 10.1097/mpa.0000000000001369
• [Journal Article] HER2 heterogeneity is a poor prognosticator for HER2-positive gastric cancer (2019)
  • Author(s): Kaito Akio、Kuwata Takeshi、Tokunaga Masanori、Shitara Kohei、Sato Reo、Akimoto Tetsuo、Kinoshita Takahiro
  • Journal Title: World Journal of Clinical Cases Volume: 7 Issue: 15 Pages: 1964-1977
  • DOI: 10.12998/wjcc.v7.i15.1964
• [Journal Article] Extra-perigastric Extranodal Metastasis is a Significant Prognostic Factor in Node-Positive Gastric Cancer. (2019)
  • Author(s): Tonouchi A, Sugano M, Tokunaga M, Sugita S, Watanabe M, Sato R, Kaito A, Akimoto T, Ochiai A, Kinoshita T, Kuwata T.
  • Journal Title: World J Surg. Volume: 43 Issue: 10 Pages: 2499-2505
  • DOI: 10.1007/s00268-019-05076-x
• [Journal Article] Frequency and predictors of detecting early locoregional recurrence/disease progression of oral squamous cell carcinoma with high-risk factors on imaging tests before postoperative adjuvant radiotherapy. (2019)
  • Author(s): Kibe Y, Nakamura N, Kuno H, Hiyama T, Hayashi R, Zenda S, Motegi A, Hojo H, Nakamura M, Ariji T, Oyoshi H, Akimoto T.
  • Journal Title: Int J Clin Oncol. Volume: 24 Issue: 10 Pages: 1182-1189
  • DOI: 10.1007/s10147-019-01479-x
  • Peer Reviewed
• [Journal Article] A review of head and neck cancer staging system in the TNM classification of malignant tumors (eighth edition) (2019)
  • Author(s): Head and Neck Cancer Study Group、Monden N、Asakage T、Kiyota N、Homma A、Matsuura K、Hanai N、Kodaira Ti、Zenda S、Fujii H、Tahara M、Yokota T、Akimoto T、Iwae S、Onitsuka T、Ogawa T、Okano S、Takahashi S、Shimizu Y、Yonezawa K、Hayashi R
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 49 Issue: 7 Pages: 589-595
  • DOI: 10.1093/jjco/hyz052
  • Peer Reviewed
• [Journal Article] Liver phantom design and dosimetric verification in participating institutions for a proton beam therapy in patients with resectable hepatocellular carcinoma: Japan Clinical Oncology Group trial (JCOG1315C) (2019)
  • Author(s): Nishio T, Tachibana H, Kase Y, Hotta K, Nakamura M, Tamura M, Terunuma T, Toshito T, Yamashita H, Ishikura S, Fuji H, Akimoto T, Nishimura Y.
  • Journal Title: Radiother Oncol. Volume: 29 Pages: 98-104
  • DOI: 10.1016/j.radonc.2019.06.005
  • Peer Reviewed
• [Journal Article] Hypofractionated proton beam therapy for centrally located lung cancer. (2019)
  • Author(s): Nakamura N, Hotta K, Zenda S, Baba H, Kito S, Akita T, Motegi A, Hojo H, Nakamura M, Parshuram RV, Okumura M, Akimoto T.
  • Journal Title: J Med Imaging Radiat Oncol. Volume: 63 Issue: 4 Pages: 552-556
  • DOI: 10.1111/1754-9485.12901
• [Journal Article] National survey on total-body irradiation prior to reduced-intensity stem cell transplantation in Japan: The Japanese Radiation Oncology Study Group. (2019)
  • Author(s): Kawaguchi H, Soejima T, Ishibashi N, Akiba T, Hasegawa M, Isobe K, Ito H, Imai M, Ejima Y, Hata M, Sasai K, Shimoda E, Oguchi M, Akimoto T; Japanese Radiation Oncology Study Group.
  • Journal Title: J Radiat Res. Volume: 60 Issue: 5 Pages: 509-516
  • DOI: 10.1093/jrr/rrz028
• [Journal Article] Organ-preserving approach via radiotherapy for small cell carcinoma of the bladder: an analysis based on the Japanese Radiation Oncology Study Group (JROSG) survey. (2019)
  • Author(s): Akamatsu H, Nakamura K, Ebara T, Inaba K, Itasaka S, Jingu K, Kosaka Y, Murai T, Nagata K, Soejima T, Takahashi S, Toyoda T, Toyoshima S, Nemoto K, Akimoto T.
  • Journal Title: J Radiat Res. Volume: 60 Issue: 4 Pages: 509-516
  • DOI: 10.1093/jrr/rrz018
  • Peer Reviewed / Open Access
• [Journal Article] Impact of EGFR Mutation and ALK Translocation on Recurrence Pattern After Definitive Chemoradiotherapy for Inoperable Stage III Non-squamous Non-small-cell Lung Cancer. (2019)
  • Author(s): Nakamura M, Kageyama SI, Niho S, Okumura M, Hojo H, Motegi A, Nakamura N, Zenda S, Yoh K, Goto K, Akimoto T.
  • Journal Title: Clin Lung Cancer. Volume: printing Issue: 3 Pages: e256-e264
  • DOI: 10.1016/j.cllc.2019.02.021
  • Peer Reviewed
• [Journal Article] Carboplatin, S-1 and concurrent thoracic radiotherapy for elderly patients with locally advanced non-small cell lung cancer: a multicenter Phase I/II study (2019)
  • Author(s): Niho Seiji、Hosomi Yukio、Okamoto Hiroaki、Nihei Keiji、Tanaka Hiroshi、Hida Toyoaki、Umemura Shigeki、Goto Koichi、Akimoto Tetsuo、Ohe Yuichiro
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 49 Issue: 7 Pages: 614-619
  • DOI: 10.1093/jjco/hyz039
• [Journal Article] Clinicopathological features and endoscopic characteristics of inverted sessile serrated adenomas/polyps. (2019)
  • Author(s): Takashima K, Oono Y, Kojima M, Ikematsu H, Akimoto T, Yano T.
  • Journal Title: Endosc Int Open Volume: 7 Issue: 03 Pages: E330-E336
  • DOI: 10.1055/a-0820-2179
  • Peer Reviewed / Open Access
• [Journal Article] Induction TPF chemotherapy followed by CRT with fractionated administration of cisplatin in patients with unresectable locally advanced head and neck cancer. (2019)
  • Author(s): Okano S, Enokida T, Onoe T, Ota Y, Motegi A, Zenda S, Akimoto T, Tahara M.
  • Journal Title: Int J Clin Oncol. Volume: 24 Issue: 7 Pages: 789-797
  • DOI: 10.1007/s10147-019-01418-w
• [Journal Article] Effect of 5-fluorouracil on cellular response to proton beam in esophageal cancer cell lines according to the position of spread-out Bragg peak. (2019)
  • Author(s): Hojo H, Dohmae T, Hotta K, Kageyama SI, Baba H, Kohno R, Motegi A, Tsuchihara K, Akimoto T.
  • Journal Title: Acta Oncol Volume: 58(4) Issue: 4 Pages: 475-482
  • DOI: 10.1080/0284186x.2018.1555373
  • Peer Reviewed
• [Journal Article] Predictive factors for hyperprogressive disease during nivolumab as anti-PD1 treatment in patients with advanced gastric cancer. (2019)
  • Author(s): Sasaki A, Nakamura Y, Mishima S, Kawazoe A, Kuboki Y, Bando H, Kojima T, Doi T, Ohtsu A, Yoshino T, Kuwata T, Akimoto T, Shitara K.
  • Journal Title: Gastric Cancer. Volume: 22 Issue: 4 Pages: 793-802
  • DOI: 10.1007/s10120-018-00922-8
  • NAID: 40021925994
  • Peer Reviewed
• [Journal Article] A primary analysis of a multicenter, prospective, single-arm, confirmatory trial of hypofractionated whole breast irradiation after breast-conserving surgery in Japan: JCOG0906. (2019)
  • Author(s): Nozaki M, Kagami Y, Shibata T, Nakamura K, Ito Y, Nishimura Y, Kawaguchi Y, Saito Y, Nagata Y, Matsumoto Y, Akimoto T, Hiraoka M; Radiation Therapy Study Group, Japan Clinical Oncology Group.
  • Journal Title: Jpn J Clin Oncol Volume: 49 Issue: 1 Pages: 57-62
  • DOI: 10.1093/jjco/hyy160
  • Peer Reviewed
• [Journal Article] Clinical impact of cachexia in unresectable locally advanced head and neck cancer: supplementary analysis of a phase II trial (JCOG0706-S2) (2019)
  • Author(s): Matsuzuka Takashi、Kiyota Naomi、Mizusawa Junki、Akimoto Tetsuo、Fujii Masato、Hasegawa Yasuhisa、Iwae Shigemichi、Monden Nobuya、Matsuura Kazuto、Onozawa Yusuke、Hayashi Ryuichi、Tahara Makoto、Japan Clinical Oncology Group(JCOG) Head and Neck Cancer Study Group
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 49 Issue: 1 Pages: 37-41
  • DOI: 10.1093/jjco/hyy145
  • Peer Reviewed / Open Access
• [Journal Article] 陽子線治療 肝細胞がん. (2019)
  • Author(s): 秋元哲夫
  • Journal Title: 先進医療NAVIGATOR がん先進医療の最前線 Volume: B42 Pages: 55-58
• [Journal Article] 頭頸部癌領域の粒子線治療の適応 (2019)
  • Author(s): 秋元哲夫
  • Journal Title: 日本耳鼻咽喉科学会誌 Volume: 122 Pages: 246-248
  • NAID: 130007629711
• [Journal Article] Usefulness of hybrid deformable image registration algorithms in prostate radiation therapy (2018)
  • Author(s): Motegi Kana、Tachibana Hidenobu、Motegi Atsushi、Hotta Kenji、Baba Hiromi、Akimoto Tetsuo
  • Journal Title: Journal of Applied Clinical Medical Physics Volume: 20 Issue: 1 Pages: 229-236
  • DOI: 10.1002/acm2.12515
  • Peer Reviewed / Open Access
• [Journal Article] Radiotherapy increases plasma levels of tumoral cell-free DNA in non-small cell lung cancer patients. (2018)
  • Author(s): Kageyama S, Nihei K, Karasawa K,, Sawada T, Koizumi F, Yamaguchi S, Kato S, Hojo H, Motegi A, Tsuchihara K, Akimoto T.
  • Journal Title: Oncotarget Volume: 10;9(27) Issue: 27 Pages: 19368-19378
  • DOI: 10.18632/oncotarget.25053
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Correction: Radiotherapy increases plasma levels of tumoral cell-free DNA in non-small cell lung cancer patients. (2018)
  • Author(s): Kageyama SI, Nihei K, Karasawa K, Sawada T, Koizumi F, Yamaguchi S, Kato S, Hojo H, Motegi A, Tsuchihara K, Akimoto T.
  • Journal Title: Oncotarget Volume: 9(34) Issue: 34 Pages: 23844-23844
  • DOI: 10.18632/oncotarget.25378
  • Peer Reviewed / Open Access
• [Journal Article] Radiotherapy increases plasma levels of tumoral cell-free DNA in non-small cell lung cancer patients. (2018)
  • Author(s): Kageyama SI, Nihei K, Karasawa K, Sawada T, Koizumi F, Yamaguchi S, Kato S, Hojo H, Motegi A, Tsuchihara K, Akimoto T.
  • Journal Title: Oncotarget. Volume: 9(27) Pages: 19368-19378
  • Peer Reviewed
• [Journal Article] Difference in the relative biological effectiveness and DNA damage repair processes in response to proton beam therapy according to the positions of the spread out Bragg peak. (2017)
  • Author(s): Hojo H, Dohmae T, Hotta K, Kohno R, Motegi A, Yagishita A, Makinoshima H, Tsuchihara K, Akimoto T
  • Journal Title: Radiat Oncol Volume: 12(1) Pages: 111-116
  • Peer Reviewed
• [Journal Article] Dosimetric comparison between proton beam therapy and photon radiation therapy for locally advanced esophageal squamous cell carcinoma (2017)
  • Author(s): Hirano Y, Onozawa M, Hojo H, Motegi A, Zenda S, Hotta K, Moriya S, Tachibana H, Nakamura N, Kojima T, Akimoto T
  • Journal Title: Radiat Oncol Volume: 13(1) Issue: 1 Pages: 474-4481
  • DOI: 10.1186/s13014-018-0966-5
  • Peer Reviewed / Open Access
• [Journal Article] Feasibility of dynamic adaptive passive scattering proton therapy with computed tomography image guidance in the lung (2017)
  • Author(s): Moriya S, Tachibana H, Hotta K, Nakamura N, Sakae T, Akimoto T.
  • Journal Title: Med Phys Volume: 44(9) Issue: 9 Pages: 4474-4481
  • DOI: 10.1002/mp.12444
  • Peer Reviewed
• [Journal Article] Proton beam therapy for olfactory neuroblastoma. (2017)
  • Author(s): Naoki Nakamura, Sadamoto Zenda, Makoto Tahara, Susumu Okano, Ryuichi Hayashi, Hidehiro Hojo, Kenji Hotta, Satoe Kito, Atsushi Motegi, Satoko Arahira, Hidenobu Tachibana, and Tetsuo Akimoto
  • Journal Title: Radiother Oncol Volume: 122(3) Issue: 3 Pages: 368-372
  • DOI: 10.1016/j.radonc.2016.12.020
  • Peer Reviewed / Open Access
• [Journal Article] Proton beam therapy for bone sarcomas of the skull base and spine: A retrospective nationwide multicenter study in Japan. (2017)
  • Author(s): Demizu Y, Mizumoto M, Onoe T, Nakamura N, Kikuchi Y, Shibata T, Okimoto T, Hideyuki S, Akimoto T, Ono K, Daimon T, Murayama S.
  • Journal Title: Cancer Sci. Volume: [Epub ahead of print] Issue: 5 Pages: 233-237
  • DOI: 10.1111/cas.13192
  • NAID: 120007129041
  • Peer Reviewed / Open Access
• [Presentation] 頭頸部癌に対する粒子線治療の進歩と可能性 (2019)
  • Author(s): 石川一樹，古平 毅，秋元哲夫，清田尚臣，石倉 聡
  • Organizer: 第43回日本頭頸部癌学会
• [Presentation] Clinical Efficacy of Proton beam therapy (2019)
  • Author(s): 秋元哲夫
  • Organizer: 第1回日中先進医療技術フォーラム
  • Invited
• [Presentation] Technical Advancement of Proton beam therapy and Radiotherapeutic technique (2019)
  • Author(s): 秋元哲夫
  • Organizer: 第1回日中先進医療技術フォーラム
  • Invited
• [Presentation] Current status and future direction of proton beam therapy in Japan (2019)
  • Author(s): 秋元哲夫
  • Organizer: THE 19th ANNUAL NATIONAL CANCER CONTROL CONFERENCE
• [Presentation] 救済外科療法困難な症例に対する放射線治療 (2019)
  • Author(s): 秋元哲夫
  • Organizer: 第17回日本臨床腫瘍学会学術集会
• [Presentation] 頭頸部癌における粒子線治療の役割 (2019)
  • Author(s): 秋元哲夫
  • Organizer: 日本頭頸部外科学会 第8回教育セミナー
• [Presentation] Phase I dose-escalation trial of proton beam therapy with concurrent full-dose chemotherapy for patients with cStage IB/Ⅱ/ (2019)
  • Author(s): Akimoto T, Kojima T, Hojo H, Onozawa M, Okumura M, Nakamura M, Motegi A, Hotta K, Baba H, Zenda S, Fujita T, Nakamura N,
  • Organizer: 61st ASTRO Annual meeting
  • Int'l Joint Research
• [Presentation] Single nucleotide polymorphism (SNP) as a predictive factor for radiation-induced toxicities (2019)
  • Author(s): 秋元哲夫
  • Organizer: 第78回日本癌学会学術総会
• [Presentation] 放射線治療効果の増強を目指した基礎・橋渡し・臨床研究 (2019)
  • Author(s): 秋元哲夫
  • Organizer: 日本放射線影響学会第62回大会
• [Presentation] 高リスク前立腺癌に対する粒子線治療 (2019)
  • Author(s): 秋元哲夫
  • Organizer: 第84回日本泌尿器学会東部総会
  • Invited
• [Presentation] 放射線生物 (2018)
  • Author(s): 秋元哲夫
  • Organizer: 日本医学放射線学会秋季臨床大会
  • Invited
• [Presentation] Proton beam therapy for esophageal squamous cell carcinoma (2018)
  • Author(s): Akimoto T
  • Organizer: Annual Scientific Meeting of TASTRO
  • Invited
• [Presentation] Current status and future direction of proton beam therapy in Japan (2018)
  • Author(s): Akimoto T
  • Organizer: Japan-Russia Medical Symposium
  • Invited
• [Presentation] Proton beam therapy for head and neck cancer. (2018)
  • Author(s): Akimoto T
  • Organizer: 日本癌治療学会総会
  • Invited
• [Presentation] Current status and future perspective of proton beam therapy in Japan (2017)
  • Author(s): Akimoto T
  • Organizer: 56th Annual Conference of the Particle Therapy Co-Operative Group
  • Int'l Joint Research / Invited
• [Presentation] Esophageal squamous cell carcinoma (2017)
  • Author(s): Akimoto T
  • Organizer: ESMO Asia
  • Int'l Joint Research / Invited
• [Presentation] Evaluation of cellular response to proton beam in esophageal cancer cell lines (2016)
  • Author(s): Hojo H, Dohmae T, Hotta K, Baba H, Akimoto T
  • Organizer: ASTRO 58th Annual Meeting
  • Place of Presentation: USA, Boston
  • Year and Date: 2016-09-22
  • Int'l Joint Research