Nuclear factor kappa B and tolerance -Immunosuppression of cancer growth and post-organ transplant-

• Project/Area Number: 16K10421
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: General surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Ochiai Takanori 東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (20447486)
• Co-Investigator(Kenkyū-buntansha): 山岡 昇司 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (90263160) ; 田中 真二 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30253420) ; 田邉 稔 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (50197513)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 肝細胞癌 / 大腸癌肝転移 / PDL1 / NF-κB / 手術 / 外科 / 免疫寛容 / 癌 / 移植

Outline of Final Research Achievements

Heapto-Biliary-Pancratic cancer is still difficult to cure, therefore multidisciplinary treatment is required. The treatment results of intractable cancer, far advanced cancer and recurrent cancer such as Heapto-Biliary-Pancratic malignancy varies in institutions, depending on surgical technique, experiences and treatment strategy at present. In this study, we clarified that multidisciplinary treatment mainly on aggressive surgical treatment with chemotherapy was effective for an intractable cancer such as the colorectal liver metastases and hepatocellular carcinoma.

Academic Significance and Societal Importance of the Research Achievements

現代の医療において、難治癌、高度進行癌、再発癌に対する治療方針は、施設により手術適応も異なるのが現状であり、手術経験や技量のほか、治療戦略も治療成績に大きく影響を及ぼす因子である。本研究では、肝細胞癌やステージIVである大腸癌肝転移といった難治癌に対して、積極的な手術療法を中心とした集学的治療が有効であることをあらためて明らかにした。

Research Products

• [Journal Article] Emergency Cholecystectomy for Patients on Antiplatelet Therapy. (2017)
  • Author(s): Akahoshi K, Ochiai T, Takaoka A, Kitamura T, Ban D, Kudo A, Tanaka S, Tanabe M.
  • Journal Title: The American Surgeon Volume: 85 Pages: 486-490
  • Peer Reviewed
• [Journal Article] Surgical pitfalls of jejunal vein anatomy in pancreaticoduodenectomy (2017)
  • Author(s): Ishikawa Yoshiya、Ban Daisuke、Matsumura Satoshi、Mitsunori Yusuke、Ochiai Takanori、Kudo Atsushi、Tanaka Shinji、Tanabe Minoru
  • Journal Title: Journal of Hepato-Biliary-Pancreatic Sciences Volume: 24 Issue: 7 Pages: 394-400
  • DOI: 10.1002/jhbp.451
  • Peer Reviewed
• [Journal Article] Acquired resistance with epigenetic alterations under long-term anti-angiogenic therapy for hepatocellular carcinoma. (2017)
  • Author(s): Ohata Y, Akiyama Y, Shimada S, Mogushi K, Nakao K, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S.
  • Journal Title: Molecular Cancer Therapeutics Volume: in press Issue: 6 Pages: 1155-1165
  • DOI: 10.1158/1535-7163.mct-16-0728
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ARID2 modulates DNA damage response in human hepatocellular carcinoma cells. (2017)
  • Author(s): Oba A, Shimada S, Akiyama Y, Nishikawaji T, Mogushi K, Ito H, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Asahara H, Kaida A, Miura M, Tanabe M, Tanaka S.
  • Journal Title: Journal of Hepatology Volume: in press Issue: 5 Pages: 942-951
  • DOI: 10.1016/j.jhep.2016.12.026
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Refractory Long-Term Cholangitis After Pancreaticoduodenectomy: A Retrospective Study (2017)
  • Author(s): Ueda Hiroki、Ban Daisuke、Kudo Atsushi、Ochiai Takanori、Tanaka Shinji、Tanabe Minoru
  • Journal Title: World Journal of Surgery Volume: 41 Issue: 7 Pages: 1882-1889
  • DOI: 10.1007/s00268-017-3912-z
  • Peer Reviewed
• [Journal Article] Proteasome activity is required for the initiation of precancerous pancreatic lesions. (2016)
  • Author(s): Furuyama T, Tanaka S, Shimada S, Akiyama Y, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Kudo A, Fukamachi H, Arii S, Kawaguchi Y, Tanabe M.
  • Journal Title: Scientific Reports Volume: 6 Issue: 1 Pages: 27044-27044
  • DOI: 10.1038/srep27044
  • NAID: 120006775931
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Preoperative direct bilirubin to prothrombin time ratio index to prevent liver failure after minor hepatectomy. (2016)
  • Author(s): Furuyama T, Kudo A, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Tanaka S, Tanabe M.
  • Journal Title: Journal of Hepatobiliary Pancreatic Sciences Volume: 23 Issue: 12 Pages: 763-770
  • DOI: 10.1002/jhbp.400
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] 肝癌破裂 (2016)
  • Author(s): 落合 高徳, 大畠 慶映, 佐藤 拓, 渡辺 秀一, 巌 康仁, 光法 雄介, 小野 宏晃, 松村 聡, 伴 大輔, 工藤 篤, 田中 真二, 田邉 稔
  • Journal Title: 臨床外科 Volume: 71 Pages: 309-313
• [Presentation] The optimal surgical management for colorectal liver metastases in the era of multidisciplinary treatment (2019)
  • Author(s): Takanori Ochiai, Takafumi Shigeno, Masayoshi Sakano, Takahiro Igaki, Norimichi Chiyonobu, Itaru Saito, Katsumasa Saito, and Shigeru Yamazaki
  • Organizer: 14th Annual Academic Surgical Congress
  • Int'l Joint Research
• [Presentation] 肝切除施行率と長期生存 大腸癌肝転移に対する治療戦略 (2018)
  • Author(s): 落合 高徳, 二瓶 健太郎, 坂野 正佳, 井垣 尊弘, 山名 浩樹, 松本 亮, 大畠 慶映, 齋藤 賢将, 入江 工, 飯田 聡, 山崎 繁
  • Organizer: 第80回日本臨床外科学会総会
• [Presentation] 長期生存例から解析した大腸癌肝転移の治療指針 (2018)
  • Author(s): 落合 高徳, 坂野 正佳, 二瓶 健太郎, 井垣 尊弘, 山名 浩樹, 松本 亮, 大畠 慶映,斎藤 賢将, 飯田 聡, 山崎 繁
  • Organizer: 第16回日本消化器外科学会大会
• [Presentation] 化学療法の奏効率と生存率を基にした大腸癌肝転移に対する治療戦略 (2018)
  • Author(s): 落合 高徳, 二瓶 健太郎, 坂野 正佳, 井垣 尊弘, 山名 浩樹, 松本 亮, 大畠 慶映, 斎藤 賢将, 入江 工, 飯田 聡, 山崎 繁
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] H2/H3大腸癌肝転移に対する治療方針 (2018)
  • Author(s): 落合 高徳, 坂野 正佳, 二瓶 健太郎, 井垣 尊弘, 山名 浩樹, 松本 亮, 大畠 慶映,斎藤 賢将, 飯田 聡, 山崎 繁
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] 大腸癌肝転移に対する肝切除と周術期化学療法の有効性 (2018)
  • Author(s): 落合 高徳, 滋野 高史, 坂野 正佳, 井垣 尊弘, 松本 亮, 千代延 記道, 斎藤 至, 斎藤 賢将, 山崎 繁
  • Organizer: 第56回日本癌治療学会学術集会
• [Presentation] Treatment strategy of colorectal cancer with liver metastases based on the response and the survival rates by chemotherapy (2018)
  • Author(s): akanori Ochiai, Takafumi Shigeno, Masayoshi Sakano, Takahiro Igaki, Ryo Matsumoto, Norimichi Chiyonobu, Itaru Saito, Katsumasa Saito and Shigeru Yamazaki
  • Organizer: Asian Pacific Digestive Week 2018
  • Int'l Joint Research
• [Presentation] Combination of liver resection and perioperative chemotherapy prolonged the survival of patients with colorectal liver metastases. (2018)
  • Author(s): Takanori Ochiai, Iida Satoru, and Shigeru Yamazaki
  • Organizer: Society of Surgical Oncology 71st Annual Cancer Symposium
  • Int'l Joint Research
• [Presentation] Combination of liver resection and perioperative chemotherapy prolonged the survival of patients with colorectal liver metastases. (2018)
  • Author(s): Takanori Ochiai, Satoru Iida, Shigeru Yamazaki
  • Organizer: The 71st Society of Surgical Oncology
  • Int'l Joint Research
• [Presentation] Surgical strategy of hepatic resection with inferior vena cava resection for liver cancers (2017)
  • Author(s): T. Ochiai, D. Asano, J. Yoshino, S. Watanabe, Y. Ishikawa, N. Chiyonobu, Y. Mizuno, T. Sato, H. Ueda, Y. Iwao, H. Ono, Y. Mitsunori, S. Matsumura, D. Ban, A. Kudo, S. Tanaka, M. Tanabe.
  • Organizer: Academic Surgical Congress 2017
  • Place of Presentation: Las Vegas (USA)
  • Year and Date: 2017-02-07
• [Presentation] Clinicopahotlogic analysis of intrahepatic recurrence of hepatocellular carcinoma after radiofrequency ablation therapy treated with hepatic resection. (2017)
  • Author(s): Takanori Ochiai, Hiroaki Ono, Yusuke Mitsunori, Satoshi Matsumura, Daisuke Ban, Atsushi Kudo, Shinji Tanaka, and Minoru Tanabe
  • Organizer: World Congress of Surgery 2017
  • Int'l Joint Research
• [Presentation] 肝細胞癌腹膜播種症例における外科的切除の検討 (2017)
  • Author(s): 落合高徳 吉野潤、浅野大輔、渡辺秀一、石川喜也、水野裕貴、千代延記道、佐藤拓、上田浩樹、巌康仁、小野宏晃、光法雄介、 松村聡、藍原有弘、伴大輔、工藤篤、田中真二、田邉稔
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] Stage IVA肝細胞癌手術症例の前治療/術後補助療法の有無に基づいた解析 (2017)
  • Author(s): 落合高徳、千代延記道、水野裕貴、上田浩樹、 大畠慶映、佐藤拓、大庭篤志、赤星径一、 伊藤浩光、松村聡、光法雄介、藍原有弘、伴大輔、工藤篤、田中真二、田邉稔
  • Organizer: 第15回日本消化器外科学会大会
• [Presentation] RFA後再発の臨床病理学的特徴と至適な肝切除のタイミング (2016)
  • Author(s): 落合高徳、渡辺秀一、石川喜也、千代延記道、水野裕貴、大畠慶映、佐藤拓、上田浩樹、大庭篤志、赤星径一、巌康仁、伊藤浩光、小野宏晃、光法雄介、松村聡、藍原有弘、伴大輔、工藤篤、田中真二、田邉稔
  • Organizer: JDDW 2016
  • Place of Presentation: 兵庫県神戸市
  • Year and Date: 2016-11-03
• [Presentation] 再肝切除を施行した肝細胞癌50例の臨床病理学的検討 (2016)
  • Author(s): 千代延記道、落合高徳、渡邊秀一、石川喜也、水野裕貴、佐藤拓、大畠慶映、上田浩樹、大庭篤志、赤星径一、巌康仁、伊藤浩光、松村聡、光法雄介、藍原有弘、伴大輔、工藤篤、田中真二、田邉稔
  • Organizer: 第28回日本肝胆膵外科学会学術集会
  • Place of Presentation: 大阪府大阪市
  • Year and Date: 2016-06-02