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Nuclear factor kappa B and tolerance -Immunosuppression of cancer growth and post-organ transplant-

Research Project

Project/Area Number 16K10421
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Ochiai Takanori  東京医科歯科大学, 大学院医歯学総合研究科, 非常勤講師 (20447486)

Co-Investigator(Kenkyū-buntansha) 山岡 昇司  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (90263160)
田中 真二  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30253420)
田邉 稔  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (50197513)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords肝細胞癌 / 大腸癌肝転移 / PDL1 / NF-κB / 手術 / 外科 / 免疫寛容 / 癌 / 移植
Outline of Final Research Achievements

Heapto-Biliary-Pancratic cancer is still difficult to cure, therefore multidisciplinary treatment is required. The treatment results of intractable cancer, far advanced cancer and recurrent cancer such as Heapto-Biliary-Pancratic malignancy varies in institutions, depending on surgical technique, experiences and treatment strategy at present. In this study, we clarified that multidisciplinary treatment mainly on aggressive surgical treatment with chemotherapy was effective for an intractable cancer such as the colorectal liver metastases and hepatocellular carcinoma.

Academic Significance and Societal Importance of the Research Achievements

現代の医療において、難治癌、高度進行癌、再発癌に対する治療方針は、施設により手術適応も異なるのが現状であり、手術経験や技量のほか、治療戦略も治療成績に大きく影響を及ぼす因子である。本研究では、肝細胞癌やステージIVである大腸癌肝転移といった難治癌に対して、積極的な手術療法を中心とした集学的治療が有効であることをあらためて明らかにした。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (23 results)

All 2019 2018 2017 2016

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 7 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (15 results) (of which Int'l Joint Research: 5 results)

  • [Journal Article] Emergency Cholecystectomy for Patients on Antiplatelet Therapy.2017

    • Author(s)
      Akahoshi K, Ochiai T, Takaoka A, Kitamura T, Ban D, Kudo A, Tanaka S, Tanabe M.
    • Journal Title

      The American Surgeon

      Volume: 85 Pages: 486-490

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Surgical pitfalls of jejunal vein anatomy in pancreaticoduodenectomy2017

    • Author(s)
      Ishikawa Yoshiya、Ban Daisuke、Matsumura Satoshi、Mitsunori Yusuke、Ochiai Takanori、Kudo Atsushi、Tanaka Shinji、Tanabe Minoru
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: 24 Issue: 7 Pages: 394-400

    • DOI

      10.1002/jhbp.451

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acquired resistance with epigenetic alterations under long-term anti-angiogenic therapy for hepatocellular carcinoma.2017

    • Author(s)
      Ohata Y, Akiyama Y, Shimada S, Mogushi K, Nakao K, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Tanabe M, Tanaka S.
    • Journal Title

      Molecular Cancer Therapeutics

      Volume: in press Issue: 6 Pages: 1155-1165

    • DOI

      10.1158/1535-7163.mct-16-0728

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] ARID2 modulates DNA damage response in human hepatocellular carcinoma cells.2017

    • Author(s)
      Oba A, Shimada S, Akiyama Y, Nishikawaji T, Mogushi K, Ito H, Matsumura S, Aihara A, Mitsunori Y, Ban D, Ochiai T, Kudo A, Asahara H, Kaida A, Miura M, Tanabe M, Tanaka S.
    • Journal Title

      Journal of Hepatology

      Volume: in press Issue: 5 Pages: 942-951

    • DOI

      10.1016/j.jhep.2016.12.026

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Refractory Long-Term Cholangitis After Pancreaticoduodenectomy: A Retrospective Study2017

    • Author(s)
      Ueda Hiroki、Ban Daisuke、Kudo Atsushi、Ochiai Takanori、Tanaka Shinji、Tanabe Minoru
    • Journal Title

      World Journal of Surgery

      Volume: 41 Issue: 7 Pages: 1882-1889

    • DOI

      10.1007/s00268-017-3912-z

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Proteasome activity is required for the initiation of precancerous pancreatic lesions.2016

    • Author(s)
      Furuyama T, Tanaka S, Shimada S, Akiyama Y, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Kudo A, Fukamachi H, Arii S, Kawaguchi Y, Tanabe M.
    • Journal Title

      Scientific Reports

      Volume: 6 Issue: 1 Pages: 27044-27044

    • DOI

      10.1038/srep27044

    • NAID

      120006775931

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Preoperative direct bilirubin to prothrombin time ratio index to prevent liver failure after minor hepatectomy.2016

    • Author(s)
      Furuyama T, Kudo A, Matsumura S, Mitsunori Y, Aihara A, Ban D, Ochiai T, Tanaka S, Tanabe M.
    • Journal Title

      Journal of Hepatobiliary Pancreatic Sciences

      Volume: 23 Issue: 12 Pages: 763-770

    • DOI

      10.1002/jhbp.400

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 肝癌破裂2016

    • Author(s)
      落合 高徳, 大畠 慶映, 佐藤 拓, 渡辺 秀一, 巌 康仁, 光法 雄介, 小野 宏晃, 松村 聡, 伴 大輔, 工藤 篤, 田中 真二, 田邉 稔
    • Journal Title

      臨床外科

      Volume: 71 Pages: 309-313

    • Related Report
      2016 Research-status Report
  • [Presentation] The optimal surgical management for colorectal liver metastases in the era of multidisciplinary treatment2019

    • Author(s)
      Takanori Ochiai, Takafumi Shigeno, Masayoshi Sakano, Takahiro Igaki, Norimichi Chiyonobu, Itaru Saito, Katsumasa Saito, and Shigeru Yamazaki
    • Organizer
      14th Annual Academic Surgical Congress
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 肝切除施行率と長期生存 大腸癌肝転移に対する治療戦略2018

    • Author(s)
      落合 高徳, 二瓶 健太郎, 坂野 正佳, 井垣 尊弘, 山名 浩樹, 松本 亮, 大畠 慶映, 齋藤 賢将, 入江 工, 飯田 聡, 山崎 繁
    • Organizer
      第80回日本臨床外科学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 長期生存例から解析した大腸癌肝転移の治療指針2018

    • Author(s)
      落合 高徳, 坂野 正佳, 二瓶 健太郎, 井垣 尊弘, 山名 浩樹, 松本 亮, 大畠 慶映,斎藤 賢将, 飯田 聡, 山崎 繁
    • Organizer
      第16回日本消化器外科学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 化学療法の奏効率と生存率を基にした大腸癌肝転移に対する治療戦略2018

    • Author(s)
      落合 高徳, 二瓶 健太郎, 坂野 正佳, 井垣 尊弘, 山名 浩樹, 松本 亮, 大畠 慶映, 斎藤 賢将, 入江 工, 飯田 聡, 山崎 繁
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] H2/H3大腸癌肝転移に対する治療方針2018

    • Author(s)
      落合 高徳, 坂野 正佳, 二瓶 健太郎, 井垣 尊弘, 山名 浩樹, 松本 亮, 大畠 慶映,斎藤 賢将, 飯田 聡, 山崎 繁
    • Organizer
      第73回日本消化器外科学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 大腸癌肝転移に対する肝切除と周術期化学療法の有効性2018

    • Author(s)
      落合 高徳, 滋野 高史, 坂野 正佳, 井垣 尊弘, 松本 亮, 千代延 記道, 斎藤 至, 斎藤 賢将, 山崎 繁
    • Organizer
      第56回日本癌治療学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Treatment strategy of colorectal cancer with liver metastases based on the response and the survival rates by chemotherapy2018

    • Author(s)
      akanori Ochiai, Takafumi Shigeno, Masayoshi Sakano, Takahiro Igaki, Ryo Matsumoto, Norimichi Chiyonobu, Itaru Saito, Katsumasa Saito and Shigeru Yamazaki
    • Organizer
      Asian Pacific Digestive Week 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Combination of liver resection and perioperative chemotherapy prolonged the survival of patients with colorectal liver metastases.2018

    • Author(s)
      Takanori Ochiai, Iida Satoru, and Shigeru Yamazaki
    • Organizer
      Society of Surgical Oncology 71st Annual Cancer Symposium
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Combination of liver resection and perioperative chemotherapy prolonged the survival of patients with colorectal liver metastases.2018

    • Author(s)
      Takanori Ochiai, Satoru Iida, Shigeru Yamazaki
    • Organizer
      The 71st Society of Surgical Oncology
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Surgical strategy of hepatic resection with inferior vena cava resection for liver cancers2017

    • Author(s)
      T. Ochiai, D. Asano, J. Yoshino, S. Watanabe, Y. Ishikawa, N. Chiyonobu, Y. Mizuno, T. Sato, H. Ueda, Y. Iwao, H. Ono, Y. Mitsunori, S. Matsumura, D. Ban, A. Kudo, S. Tanaka, M. Tanabe.
    • Organizer
      Academic Surgical Congress 2017
    • Place of Presentation
      Las Vegas (USA)
    • Year and Date
      2017-02-07
    • Related Report
      2016 Research-status Report
  • [Presentation] Clinicopahotlogic analysis of intrahepatic recurrence of hepatocellular carcinoma after radiofrequency ablation therapy treated with hepatic resection.2017

    • Author(s)
      Takanori Ochiai, Hiroaki Ono, Yusuke Mitsunori, Satoshi Matsumura, Daisuke Ban, Atsushi Kudo, Shinji Tanaka, and Minoru Tanabe
    • Organizer
      World Congress of Surgery 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肝細胞癌腹膜播種症例における外科的切除の検討2017

    • Author(s)
      落合高徳 吉野潤、浅野大輔、渡辺秀一、石川喜也、水野裕貴、千代延記道、佐藤拓、上田浩樹、巌康仁、小野宏晃、光法雄介、 松村聡、藍原有弘、伴大輔、工藤篤、田中真二、田邉稔
    • Organizer
      第118回日本外科学会定期学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Stage IVA肝細胞癌手術症例の前治療/術後補助療法の有無に基づいた解析2017

    • Author(s)
      落合高徳、千代延記道、水野裕貴、上田浩樹、 大畠慶映、佐藤拓、大庭篤志、赤星径一、 伊藤浩光、松村聡、光法雄介、藍原有弘、伴大輔、工藤篤、田中真二、田邉稔
    • Organizer
      第15回日本消化器外科学会大会
    • Related Report
      2017 Research-status Report
  • [Presentation] RFA後再発の臨床病理学的特徴と至適な肝切除のタイミング2016

    • Author(s)
      落合高徳、渡辺秀一、石川喜也、千代延記道、水野裕貴、大畠慶映、佐藤拓、上田浩樹、大庭篤志、赤星径一、巌康仁、伊藤浩光、小野宏晃、光法雄介、松村聡、藍原有弘、伴大輔、工藤篤、田中真二、田邉稔
    • Organizer
      JDDW 2016
    • Place of Presentation
      兵庫県神戸市
    • Year and Date
      2016-11-03
    • Related Report
      2016 Research-status Report
  • [Presentation] 再肝切除を施行した肝細胞癌50例の臨床病理学的検討2016

    • Author(s)
      千代延記道、落合高徳、渡邊秀一、石川喜也、水野裕貴、佐藤拓、大畠慶映、上田浩樹、大庭篤志、赤星径一、巌康仁、伊藤浩光、松村聡、光法雄介、藍原有弘、伴大輔、工藤篤、田中真二、田邉稔
    • Organizer
      第28回日本肝胆膵外科学会学術集会
    • Place of Presentation
      大阪府大阪市
    • Year and Date
      2016-06-02
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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