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Graftr protection and preoperative viability estimation in Llver transplantation from donors after cardiac death

Research Project

Project/Area Number 16K10430
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionEhime University

Principal Investigator

Takada Yasutsugu  愛媛大学, 医学系研究科, 教授 (10272197)

Research Collaborator Ogawa Kohei  
Sakamoto Katsunori  
Tamura Kei  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords肝移植 / 心停止ドナー / トランスレーショナル研究 / トランスレーショナルリサーチ / 移植
Outline of Final Research Achievements

Use of liver grafts from donors after cardiac death (DCD) is one of the ways to attenuate the organ shortage in clinical liver transplantation (LT). To introduce the DCD-LT in Japan, we conducted a study of porcine LT using DCD as a translational research. As a results, porcine model of DCD-LT operation has been established. In addition, the efficacy of pharmacological graft protection has been suggested in a rat DCD LT model.

Academic Significance and Societal Importance of the Research Achievements

本邦での現状において、DCD肝移植を行うとしてもしグラフト不全に陥った場合、再移植に必要なsecond liverが得られにくい。そこで本研究ではDCD肝移植を本邦において安全に臨床導入するための課題であるグラフト肝機能保護法と、移植前のグラフト肝viabilityの正確な評価法、の2つの確立をめざし、その可能性を示唆する成果が得られた。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (16 results)

All 2019 2018 2017 2016

All Journal Article (10 results) (of which Peer Reviewed: 10 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 4 results,  Invited: 5 results)

  • [Journal Article] Impact of pretreatments on outcomes after living donor liver transplantation for hepatocellular carcinoma2019

    • Author(s)
      Ogawa Kohei、Kaido Toshimi、Okajima Hideaki、Fujimoto Yasuhiro、Yoshizawa Atsushi、Yagi Shintaro、Hori Tomohide、Iida Taku、Takada Yasutsugu、Uemoto Shinji
    • Journal Title

      Journal of Hepato-Biliary-Pancreatic Sciences

      Volume: 26 Issue: 2 Pages: 73-81

    • DOI

      10.1002/jhbp.602

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Preformed donor‐specific antibodies are associated with 90‐day mortality in living‐donor liver transplantation2019

    • Author(s)
      Tamura Kei、Tohyama Taiji、Watanabe Jota、Nakamura Taro、Ueno Yoshitomo、Inoue Hitoshi、Honjo Masahiko、Sakamoto Katsunori、Takai Akihiro、Ogawa Kohei、Takada Yasutsugu
    • Journal Title

      Hepatology Research

      Volume: in press Issue: 8 Pages: 929-941

    • DOI

      10.1111/hepr.13352

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quality of life after single-incision laparoscopic cholecystectomy: A randomized, clinical trial2019

    • Author(s)
      Ito Eitaro、Takai Akihiro、Imai Yoshinori、Otani Hiromi、Onishi Yoshihiro、Yamamoto Yosuke、Ogawa Kohei、Tohyama Taiji、Fukuhara Shunichi、Takada Yasutsugu
    • Journal Title

      Surgery

      Volume: 165 Issue: 2 Pages: 353-359

    • DOI

      10.1016/j.surg.2018.08.004

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] “Real-time” risk models of postoperative morbidity and mortality for liver transplants2018

    • Author(s)
      Marubashi Shigeru, Ichihara Naoaki, Kakeji Yoshihiro, Miyata Hiroaki, Taketomi Akinobu, Egawa Hiroto, Takada Yasutsugu, Umeshita Koji, Seto Yasuyuki, Gotoh Mitsukazu
    • Journal Title

      Annals of Gastroenterological Surgery

      Volume: 3 Issue: 1 Pages: 75-95

    • DOI

      10.1002/ags3.12217

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serosal invasion is a strong prognostic factor for hepatocellular carcinoma after hepatectomy2018

    • Author(s)
      Sakamoto Katsunori、Ogawa Kohei、Tohyama Taiji、Ueno Yoshitomo、Tamura Kei、Inoue Hitoshi、Nakamura Taro、Watanabe Jota、Takai Akihiro、Takada Yasutsugu
    • Journal Title

      Hepatology Research

      Volume: 49 Issue: 4 Pages: 419-431

    • DOI

      10.1111/hepr.13285

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Significance of preoperative fluorodeoxyglucose-positron emission tomography in prediction of tumor recurrence after liver transplantation for hepatocellular carcinoma patients: a Japanese multicenter study.2017

    • Author(s)
      Takada Y, Kaido T, Shirabe K, Nagano H, Egawa H, Yamaue H.
    • Journal Title

      J Hepatobiliary Pancreat Sci.

      Volume: 24 Issue: 1 Pages: 49-57

    • DOI

      10.1002/jhbp.412

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Living vs. deceased-donor liver transplantation for patients with hepatocellular carcinoma.2016

    • Author(s)
      Kohei Ogawa, Yasutsugu Takada.
    • Journal Title

      Transl Gastroenterol Hepatol

      Volume: 1 Pages: 35-44

    • DOI

      10.21037/tgh.2016.04.03

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of psoas muscle index on short-term outcome after living donor liver transplantation.2016

    • Author(s)
      Izumi T, Watanabe J, Tohyama T, Takada Y.
    • Journal Title

      Turk J Gastroenterol

      Volume: 27 Issue: 4 Pages: 382-388

    • DOI

      10.5152/tjg.2016.16201

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of human T-cell leukemia virus type 1 on living donor liver transplantation: a multi-center study in Japan.2016

    • Author(s)
      Yoshizumi T et al.
    • Journal Title

      Hepatobiliary Pancreat Sci

      Volume: 23(6) Issue: 6 Pages: 333-41

    • DOI

      10.1002/jhbp.345

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recovery after critical illness polyneuropathy in a patient with orthotopic liver transplantation: A case report.2016

    • Author(s)
      Watanabe J, Ito E, Hatano M, Tohyama T, Okada Y, Takada Y.
    • Journal Title

      Transplant Proc.

      Volume: 48 Issue: 9 Pages: 3207-3209

    • DOI

      10.1016/j.transproceed.2016.09.005

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] Optimal selection criteria for Liver transplantation for HCC patients.2018

    • Author(s)
      Takada Y
    • Organizer
      IASGO World Congress 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Significance of preoperative FDG-PET in prediction of tumor recurrence after liver transplantation for HCC patients:A Japanese multicenter study2018

    • Author(s)
      Takada Y
    • Organizer
      第30回日本肝胆膵外科学会学術集会
    • Related Report
      2018 Annual Research Report
    • Invited
  • [Presentation] 当院における原発性胆汁性胆管炎に対する肝移植成績2018

    • Author(s)
      小川晃平、髙井昭洋、井上 仁、坂元克考、本庄真彦、宇都宮健、上野義智、松井貴司、高田泰次
    • Organizer
      第54回日本移植学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Liver transplantation for HCC: optimal selection criteria.2017

    • Author(s)
      Takada Y.
    • Organizer
      IASGO World Congress 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Liver transplantation for HCC: optimal selection criteria. Invited speaker.2016

    • Author(s)
      Takada Y.
    • Organizer
      Asia-Pacific Digestive Week (APDW) 2016
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2016-11-02
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] HCC with Child A; Hepatectomy first-. Hot Debate.2016

    • Author(s)
      Takada Y.
    • Organizer
      26th World Congress of the International Association of Surgeons, Gastroenterologists and Oncologists
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2016-09-08
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

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Published: 2016-04-21   Modified: 2020-03-30  

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