| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
Cancer is genomically and phenotypically diverse and composed of complex tissues, including tumor microenvironments and a heterogeneous population of cancer cells, all showing different characteristics. We formed heterogeneous cancer tissues by mixing two different human-derived triple-negative breast cancer cell lines and inoculating them into the mammary fat pads of immunodeficient mice. These heterogeneous cancers were more proliferative than the homogeneous cancers that were formed by individually inoculating the cell lines. We performed RNA-sequencing analysis to identify the genes which characteristically expressed in heterogeneous cancer tissues. Our hallmark genes seem to be involved in tumor growth and could be important biomarkers of intratumoral heterogeneity associated with malignancy and therapeutic resistance of breast cancers.
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