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Elucidation of the adrenal gland regeneration mechanism and application to adrenocortical autotransplantation

Research Project

Project/Area Number 16K10483
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionKansai Medical University

Principal Investigator

YOSHIDA Takashi  関西医科大学, 医学部, 助教 (00714966)

Co-Investigator(Kenkyū-buntansha) 松田 公志  関西医科大学, 医学部, 教授 (20192338)
田中 進  関西医科大学, 医学部, 准教授 (30399472)
Research Collaborator TAKIZAWA Nae  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords副腎 / 自家移植 / 再生 / DHH / GLI1 / Dhh / Gli1 / 副腎皮質 / 内分泌外科学 / 移植・再生医学
Outline of Final Research Achievements

Bilateral adrenalectomy forces the patient to undergo glucocorticoid replacement therapy and face a lifetime risk of adrenal crisis. Adrenal autotransplantation is considered useful to avoid adrenal crisis and the replacement therapy. However, the basic process of regeneration in adrenal autografts is poorly understood. Here, we investigated the essential regeneration factors in rat adrenocortical autografts, with a focus on the factors involved in adrenal development and steroidogenesis, such as Hh signalling. The autografts showed increased Dhh expressions 3 weeks after autotransplantation, but not Shh, which is the only Hh family member to have been reported to be expressed in the adrenal gland. Increased Gli1 expression was also found in the regenerated capsule 3 weeks after autotransplantation. Dhh and Gli1 might function in cooperation to regenerate adrenocortical autografts. This is the first report to clearly show Dhh expression and its elevation in the adrenal gland.

Academic Significance and Societal Importance of the Research Achievements

副腎皮質移植片の再生過程におけるヘッジホッグ経路のタンパク、遺伝子を検討した研究は皆無である。本研究では移植片再生過程でShhではなくDhhの発現上昇を認めるという、これまでの通説を覆す結果を得た。DHHの副腎皮質自家移植片における組織再構築と内分泌機能獲得への関与が示唆された。
この研究成果は、副腎自家移植片の機能増強、ならびに早期生着方法を導き出し、自家移植のみならず、幹細胞移植、異種移植への応用も可能としていく。すなわち、本研究による成果は対象疾患を家族性褐色細胞腫に限定せず、ACTH非依存性副腎皮質大結節性過形成やAddison病の加療にも応用できることが期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (19 results)

All 2018 2017 2016

All Journal Article (13 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 13 results,  Open Access: 3 results) Presentation (6 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Involvement of DHH and GLI1 in adrenocortical autograft regeneration in rats2018

    • Author(s)
      Takizawa Nae、Tanaka Susumu、Oe Souichi、Koike Taro、Yoshida Takashi、Hirahara Yukie、Matsuda Tadashi、Yamada Hisao
    • Journal Title

      Scientific Reports

      Volume: 8 Issue: 1 Pages: 14542-14542

    • DOI

      10.1038/s41598-018-32870-9

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The narrow vesicourethral angle measured on postoperative cystography can predict urinary incontinence after robot-assisted laparoscopic radical prostatectomy2018

    • Author(s)
      Sugi Motohiko、Kinoshita Hidefumi、Yoshida Takashi、Taniguchi Hisanori、Mishima Takao、Yoshida Kenji、Yanishi Masaaki、Komai Yoshihiro、Watanabe Masato、Matsuda Tadashi
    • Journal Title

      Scand J Urol Nephrol

      Volume: 1 Issue: 2 Pages: 1-6

    • DOI

      10.1080/21681805.2018.1428683

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Laparoendoscopic single-site surgery for treatment of urachal remnants.2017

    • Author(s)
      Yanishi M, Kinoshita H, Yoshida T, Taniguchi H, Yoshida K, Mishima T, Komai Y, Yasuda K, Sugi M, Matsuda T.
    • Journal Title

      Can J Urol

      Volume: 24 Pages: 9098-9102

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of the Clinical Utility of Renin-Angiotensin System Inhibitors in Patients Undergoing Radical Surgery for Urothelial Carcinoma of the Upper Urinary Tract2017

    • Author(s)
      Yoshida Takashi、Matsuzaki Tomoaki、Murota Takashi、Kawa Gen、Matsuda Tadashi、Kinoshita Hidefumi
    • Journal Title

      Clin Genitourin Cancer

      Volume: 15 Issue: 6 Pages: e943-e954

    • DOI

      10.1016/j.clgc.2017.05.003

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Successful Treatment of Transplant Renal Artery Thrombosis With Systemic Infusion of Recombinant-Tissue-Plasminogen Activator After Renal Transplant.2017

    • Author(s)
      Yoshida Takashi, Yanishi Masaaki, Nakamoto Takashi, Sugi Motohiko, Kinoshita Hidefumi, Matsuda Tadashi.
    • Journal Title

      Exp Clin Transplant

      Volume: 15 Pages: 571-573

    • Related Report
      2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Current trends and pitfalls in endoscopic treatment of urolithiasis2017

    • Author(s)
      Inoue Takaaki、Okada Shinsuke、Hamamoto Shuzo、Yoshida Takashi、Matsuda Tadashi
    • Journal Title

      Int J Urol

      Volume: 25 Issue: 2 Pages: 121-133

    • DOI

      10.1111/iju.13491

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Introduction of an Enhanced Recovery after Surgery Protocol for Robot-Assisted Laparoscopic Radical Prostatectomy.2017

    • Author(s)
      Sugi M, Matsuda T, Yoshida T, Taniguchi H, Mishima T, Yanishi M, Komai Y, Yasuda K, Kinoshita H, Yoshida K, Watanabe M.
    • Journal Title

      Urol Int.

      Volume: 印刷中 Issue: 2 Pages: 194-200

    • DOI

      10.1159/000457805

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic Impact of Renin-Angiotensin Inhibitors in Patients with Bladder Cancer Undergoing Radical Cystectomy.2017

    • Author(s)
      Yoshida T, Kinoshita H, Fukui K, Matsuzaki T, Yoshida K, Mishima T, Yanishi M, Komai Y, Sugi M, Inoue T, Murota T, Matsuda T.
    • Journal Title

      Ann Surg Oncol.

      Volume: 24 Issue: 3 Pages: 823-831

    • DOI

      10.1245/s10434-016-5534-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Preoperative Pyuria Is a Poor Prognostic Factor in Patients With Urothelial Carcinoma of the Upper Urinary Tract After Surgery.2016

    • Author(s)
      Yoshida T, Kinoshita H, Shimada S, Sugi M, Matsuda T.
    • Journal Title

      Clin Genitourin Cancer.

      Volume: 印刷中 Issue: 4 Pages: e543-e550

    • DOI

      10.1016/j.clgc.2016.12.021

    • Related Report
      2017 Research-status Report 2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Perioperative change in neutrophil-lymphocyte ratio predicts the overall survival of patients with bladder cancer undergoing radical cystectomy.2016

    • Author(s)
      Yoshida T, Kinoshita H, Yoshida K, Mishima T, Yanishi M, Komai Y, Sugi M, Murota T, Kawa G, Matsuda T.
    • Journal Title

      Jpn J Clin Oncol.

      Volume: 46 Pages: 1162-1167

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of live donor pretransplant and recipient posttransplant renal volumes.2016

    • Author(s)
      6)Yanishi M, Kinoshita H, Yoshida T, Takayasu K, Yoshida K, Mishima T, Sugi M, Tsukaguchi H, Kawa G, Matsuda T
    • Journal Title

      Clin Transplant.

      Volume: May 1 Issue: 5 Pages: 613-8

    • DOI

      10.1111/ctr.12727

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intravesical Prostatic Protrusion as a Predicting Factor for the Adverse Clinical Outcome in Patients With Symptomatic Benign Prostatic Enlargement Treated With Dutasteride.2016

    • Author(s)
      Yoshida T, Kinoshita H, Yoshida K, Mishima T, Taniguchi H, Yanishi M, Komai Y, Yasuda K, Sugi M, Matsuda T.
    • Journal Title

      Urology.

      Volume: 91 Pages: 154-7

    • DOI

      10.1016/j.urology.2016.01.009

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prognostic impact of perioperative lymphocyte-monocyte ratio in patients with bladder cancer undergoing radical cystectomy.2016

    • Author(s)
      Yoshida T, Kinoshita H, Yoshida K, Mishima T, Yanishi M, Inui H, Komai Y, Sugi M, Inoue T, Murota T, Fukui K, Harada J, Kawa G, Matsuda T.
    • Journal Title

      Tumour Biol.

      Volume: 37 Issue: 8 Pages: 10067-74

    • DOI

      10.1007/s13277-016-4874-8

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] 上部尿路腫瘍患者における、予後因子としての術前膿尿の意義2017

    • Author(s)
      吉田崇, 木下秀文, 島田誠治, 杉素彦, 松田公志
    • Organizer
      第105回日本泌尿器科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 上部尿路腫瘍患者における、予後因子としての術前膿尿の意義2017

    • Author(s)
      吉田崇, 木下秀文, 松田公志
    • Organizer
      日本泌尿器腫瘍学会第3回学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] シンポジウム15:浸潤性膀胱癌の治療戦略2017

    • Author(s)
      吉田崇
    • Organizer
      第67回日本泌尿器科学会中部総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 膀胱全摘術を受けた膀胱癌患者における、好中球/リンパ球の術前後変化の予後予測因子としての有用性2016

    • Author(s)
      吉田崇, 木下秀文, 室田卓之, 河源, 松田公志
    • Organizer
      日本泌尿器腫瘍学会第2回学術集会
    • Place of Presentation
      横浜市 ランドマークホール
    • Year and Date
      2016-10-22
    • Related Report
      2016 Research-status Report
  • [Presentation] Prognostic impact of perioperative lymphocyte-monocyte ratio (LMR) in patients with bladder cancer undergoing radical cystectomy2016

    • Author(s)
      Yoshida Takashi
    • Organizer
      111th American Urological Association(AUA)  Annual Meeting 2016
    • Place of Presentation
      サンディエゴ アメリカ合衆国
    • Year and Date
      2016-05-06
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] 膀胱全摘を施行した尿路上皮癌症例における、術前リンパ球/単球比と術後病理結果を用いた予後リスク分類の構築2016

    • Author(s)
      吉田崇, 木下秀文, 吉田健志, 矢西正明, 乾秀和, 駒井資弘, 杉素彦, 井上貴昭, 室田卓之, 松田公志
    • Organizer
      第104回日本泌尿器科学会総会
    • Place of Presentation
      仙台市 仙台国際センター、東北大学百周年記念館
    • Year and Date
      2016-04-23
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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