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Development of retroviral replicating vector-mediated suicide gene therapy for malignant mesothelioma

Research Project

Project/Area Number 16K10484
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General surgery
Research InstitutionHyogo Medical University

Principal Investigator

KUBO Shuji  兵庫医科大学, 医学部, 准教授 (10441320)

Co-Investigator(Kenkyū-buntansha) 山野 智基  兵庫医科大学, 医学部, 准教授 (00599318)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywordsがんウイルス療法 / 増殖型レトロウイルス / 自殺遺伝子 / 間葉系幹細胞 / 増殖型レトロウイルスベクター / がん自殺遺伝子療法 / 癌 / 細胞・遺伝子治療 / ウイルス療法
Outline of Final Research Achievements

Retroviral replicating vectors (RRV) have demonstrated efficient tumor transduction and dramatic survival benefit when employed for suicide gene in a variety of cancer models. In order to increase transduction efficiency and enhance therapeutic effect, we have created two different RRVs (AMLV and GALV) that use different receptors. Using these vectors, we showed a potential feasibility of a personalized virotherapy on the basis of the cellular receptor expression profiles, and also a dual-vector suicide gene therapy using two different RRVs carrying different suicide genes. Furthermore, we also showed the potential utility of tumor-homing mesenchymal stem cells to deliver RRV more efficiently and further enhance the efficacy of RRV-mediated gene therapy for systemic and metastatic cancers.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果により、RRVを用いた自殺遺伝子療法の効果増強及び適応拡大が期待され、臨床応用可能な実用性の高いウイルス療法開発につながることが期待される。悪性中皮腫のみならず、播種性癌の患者の予後やQuality of Lifeを大きく改善する可能性がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (23 results)

All 2019 2018 2017 2016

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (20 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Splicing modulator FR901464 is a potential agent for colorectal cancer in combination therapy2019

    • Author(s)
      Yamano Tomoki、Kubo Shuji、Yano Aya、Kominato Tomoko、Tanaka Shino、Ikeda Masataka、Tomita Naohiro
    • Journal Title

      Oncotarget

      Volume: 10 Issue: 3 Pages: 352-367

    • DOI

      10.18632/oncotarget.26564

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dual-vector prodrug activator gene therapy using retroviral replicating vectors2018

    • Author(s)
      Kubo Shuji、Takagi-Kimura Misato、Tagawa Masatoshi、Kasahara Noriyuki
    • Journal Title

      Cancer Gene Therapy

      Volume: Epub ahead of print Issue: 5-6 Pages: 128-135

    • DOI

      10.1038/s41417-018-0051-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficient tumor transduction and antitumor efficacy in experimental human osteosarcoma using retroviral replicating vectors2018

    • Author(s)
      Kubo Shuji、Takagi-Kimura Misato、Kasahara Noriyuki
    • Journal Title

      Cancer Gene Therapy

      Volume: 26 Issue: 1-2 Pages: 41-47

    • DOI

      10.1038/s41417-018-0037-y

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Potential Utility of Mesenchymal Stem Cells as Retroviral Replicating Vector Delivery Vehicles for Gene Therapy of Cancer2018

    • Author(s)
      Shuji Kubo, Misato Takagi-Kimura and Noriyuki Kasahara
    • Organizer
      21th Annual Meeting of the American Society of Gene & Cell Therapy
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 骨肉腫に対する細胞死誘導型がんウイルス療法2018

    • Author(s)
      久保秀司、木村(高木)美智、笠原典之
    • Organizer
      第25回日本遺伝子診療学会大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Human Mesenchymal Stem Cells as Cellular Vehicles to Deliver Retroviral Replicating Vectors for Cancer Gene Therapy2018

    • Author(s)
      Shuji Kubo, Misato Takagi-Kimura and Noriyuki Kasahara
    • Organizer
      第24回日本遺伝子細胞治療学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mesenchymal Stem Cells Can Be Used As Carriers Of Retroviral Replicating Vectors For Cancer Gene Therapy2018

    • Author(s)
      久保秀司、木村(高木)美智、山野智基、田川雅敏、笠原典之
    • Organizer
      第77回日本癌学会学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 幹細胞をキャリアとして利用した増殖型レトロウイルスによる癌自殺遺伝子療法の開発2018

    • Author(s)
      久保秀司、木村(高木)美智、笠原典之
    • Organizer
      日本人類遺伝学会第63回大会
    • Related Report
      2018 Annual Research Report
  • [Presentation] uman Mesenchymal Stem Cells as Cellular Vehicles to Deliver Retroviral Replicating Vectors for Cancer Gene Therapy2018

    • Author(s)
      Shuji Kubo, Misato Takagi-Kimura, Masatoshi Tagawa, Noriyuki Kasahara
    • Organizer
      Annual Meeting of the European Society of Gene and Cell Therapy 2018
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Retroviral replicating vector-mediated suicide gene therapy for solid tumors2018

    • Author(s)
      Shuji Kubo, Misato Takagi-Kimura, Lisa Isoda, Noriyuki Kasahara
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] Mesenchymal stem cells as carriers of retroviral replicating vectors for cancer gene therapy2018

    • Author(s)
      Misato Takagi-Kimura, Lisa Isoda, Noriyuki Kasahara, Shuji Kubo
    • Organizer
      第41回日本分子生物学会年会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 増殖型レトロウイルスを用いた自殺遺伝子療法の開発2017

    • Author(s)
      久保秀司
    • Organizer
      2017年度生命科学系学会合同年次大会(第40回日本分子生物学会年会)
    • Related Report
      2017 Research-status Report
  • [Presentation] Prodrug activator gene therapy using retroviral replicating vectors in an experimental model of human osteosarcoma2017

    • Author(s)
      Kubo S, Takagi-Kimura M, Kasahara N
    • Organizer
      20th Annual Meeting of the American Society of Gene & Cell Therapy
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Retroviral replicating vector-mediated prodrug activator gene therapy in an experimental model of human osteosarcoma2017

    • Author(s)
      Kubo S, Takagi-Kimura M, Kasahara N
    • Organizer
      Annual Meeting of the European Society of Gene and Cell Therapy 2017
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 増殖型レトロウイルスを用いた細胞死誘導型癌ウイルス療法の開発2017

    • Author(s)
      久保秀司
    • Organizer
      金沢大学薬学シンポジウム2017
    • Related Report
      2017 Research-status Report
  • [Presentation] Retroviral replicating vector-mediated prodrug activator gene therapy for osteosarcoma2017

    • Author(s)
      Kubo S, Takagi-Kimura M, Kasahara N
    • Organizer
      第23回日本遺伝子細胞治療学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] Retroviral replicating vector-mediated suicide gene therapy for osteosarcoma2017

    • Author(s)
      久保秀司、木村(高木)美智、山野智基、笠原典之
    • Organizer
      第76回日本癌学会学術総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Suicide gene therapy using retroviral replicating vectors in an experimental model of human osteosarcoma2017

    • Author(s)
      Shuji Kubo, Misato Takagi-Kimura, Noriyuki Kasahara
    • Organizer
      第62回日本人類遺伝学会第62回大会
    • Related Report
      2017 Research-status Report
  • [Presentation] 増殖型レトロウイルスを用いた個別化ウイルス療法の可能性2016

    • Author(s)
      久保秀司、山野智基、笠原典之
    • Organizer
      第39回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-12-01
    • Related Report
      2016 Research-status Report
  • [Presentation] Customization of virotherapy with retroviral replicating vectors on the basis of cellular receptor expression profiles.2016

    • Author(s)
      Kubo S, Mawatari-Furukawa Y, Kasahara N
    • Organizer
      Annual Meeting of the European Society of Gene and Cell Therapy 2016
    • Place of Presentation
      Florence, Italy
    • Year and Date
      2016-10-18
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] A tailor-made virotherapy with retroviral replicating vectors on the basis of the receptor expression2016

    • Author(s)
      Kubo S, Yamano T, Kasahara N
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] Customization of virotherapy with replicating retroviral replicating vectors on the basis of cellular receptor expression profiles.2016

    • Author(s)
      Kubo S, Mawatari-Furukawa Y, Sakagami R, Kasahara N
    • Organizer
      第22回日本遺伝子細胞治療学会学術総会
    • Place of Presentation
      慈恵医科大学(東京都港区)
    • Year and Date
      2016-07-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Combinatorial anti-angiogenic gene therapy in a human malignant mesothelioma model.2016

    • Author(s)
      Kubo S, Takagi-Kimura M, Logg CR, Hermann K, Kasahara N
    • Organizer
      19th Annual Meeting of the American Society of Gene & Cell Therapy
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2016-05-04
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research

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Published: 2016-04-21   Modified: 2020-03-30  

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