Development of novel epigenetic marker in gastric cancer

• Project/Area Number: 16K10497
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Mie University
• Principal Investigator: Imaoka Hiroki 三重大学, 医学系研究科, リサーチアソシエイト (70762938)
• Co-Investigator(Kenkyū-buntansha): 問山 裕二 三重大学, 医学部附属病院, 准教授 (00422824) ; 大井 正貴 三重大学, 医学部附属病院, 准教授 (40418752) ; 楠 正人 三重大学, 医学系研究科, 教授 (50192026) ; 吉山 繁幸 三重大学, 医学系研究科, リサーチアソシエイト (60444436) ; 毛利 靖彦 三重大学, 医学系研究科, 客員准教授 (70345974)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2017: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 胃癌 / 腹膜播種 / バイオマーカー / snoRNA / 消化管悪性腫瘍 / 診断マーカー / 予後マーカー

Outline of Final Research Achievements

The aim of this study was to identify clinically relevant epigenetic markers for presence of peritoneal dissemination in gastric cancer. Array-based comprehensive analysis demonstrated that miRNA panel could identify GC patients harboring peritoneal dissemination. Furthermore, gene expression analysis demonstrated that increased L1CAM expression was deeply involved in peritoneal metastasis and poor prognosis in gastric cancer patients.

Academic Significance and Societal Importance of the Research Achievements

本研究結果を用いることで、学術的意義としては、腹膜播種を早期に診断・同定し、治療方針の決定に有用となる可能性が考慮された。

Research Products

• [Journal Article] Soluble PD-L1 Expression in Circulation as a Predictive Marker for Recurrence and Prognosis in Gastric Cancer: Direct Comparison of the Clinical Burden Between Tissue and Serum PD-L1 Expression. (2019)
  • Author(s): Shigemori T, Toiyama Y, Okugawa Y, Yamamoto A, Yin C, Narumi A, Ichikawa T, Ide S, Shimura T, Fujikawa H, Yasuda H, Hiro J, Yoshiyama S, Ohi M, Araki T, Kusunoki M.
  • Journal Title: Ann Surg Oncol. Volume: 26 Issue: 3 Pages: 876-883
  • DOI: 10.1245/s10434-018-07112-x
  • Peer Reviewed / Open Access
• [Journal Article] Colony-stimulating factor-1 and colony-stimulating factor-1 receptor co-expression is associated with disease progression in gastric cancer. (2018)
  • Author(s): Okugawa Y, Toiyama Y, Ichikawa T, Kawamura M, Yasuda H, Fujikawa H, Saigusa S, Ohi M, Araki T, Tanaka K, Inoue Y, Tanaka M, Miki C, Kusunoki M.
  • Journal Title: Int J Oncol. Volume: 53 Pages: 737-749
  • DOI: 10.3892/ijo.2018.4406
  • Peer Reviewed
• [Journal Article] Enhanced AZIN1 RNA editing and overexpression of its regulatory enzyme ADAR1 are important prognostic biomarkers in gastric cancer (2018)
  • Author(s): Okugawa Yoshinaga、Toiyama Yuji、Shigeyasu Kunitoshi、Yamamoto Akira、Shigemori Tsunehiko、Yin Chengzeng、Ichikawa Takashi、Yasuda Hiromi、Fujikawa Hiroyuki、Yoshiyama Shigeyuki、Hiro Junichiro、Ohi Masaki、Araki Toshimitsu、Kusunoki Masato、Goel Ajay
  • Journal Title: Journal of Translational Medicine Volume: 16 Issue: 1 Pages: 366-366
  • DOI: 10.1186/s12967-018-1740-z
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical significance of SNORA42 as an oncogene and a prognostic biomarker in colorectal cancer. (2017)
  • Author(s): Okugawa Y, Toiyama Y, Toden S, Mitoma H, Nagasaka T, Tanaka K, Inoue Y, Kusunoki M, Boland CR, Goel A.
  • Journal Title: Gut Volume: 66 Issue: 1 Pages: 107-117
  • DOI: 10.1136/gutjnl-2015-309359
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant