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Additional effects of duodenojejunal bypass on glucose metabolism and hypothalamic feeding center in a rat model of sleeve gastrectomy.

Research Project

Project/Area Number 16K10505
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionOita University

Principal Investigator

Ohta Masayuki  大分大学, 国際教育研究推進機構, 教授 (80271104)

Co-Investigator(Kenkyū-buntansha) 猪股 雅史  大分大学, 医学部, 教授 (60315330)
岩下 幸雄  大分大学, 医学部, 講師 (60534203)
遠藤 裕一  大分大学, 医学部, 助教 (20468010)
高山 洋臣  大分大学, 医学部, 客員研究員 (50733614)
嵯峨 邦裕  大分大学, 医学部, 客員研究員 (50770145)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2018: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords肥満外科手術 / メタボリックサージェリー / スリーブ状胃切除術 / スリーブバイパス術 / バイパス手術 / 肥満外科 / 肥満治療 / 摂食中枢 / 消化管ホルモン
Outline of Final Research Achievements

Sleeve gastrectomy with duodenojejunal bypass (SG-DJB) is expected to become a popular procedure. The aim of this study was to evaluate the effects of duodenojejunal bypass on glucose metabolism in a rat model of sleeve gastrectomy (SG). Twenty-four Sprague-Dawley rats were divided into two groups, SG-DJB and SG alone. Six weeks after surgery, oral glucose tolerance tests (OGTT) were performed. Expression of factors related to gluconeogenesis and glucose transport were evaluated using jejunal samples. During the OGTT, SG-DJB group showed an early increase in serum insulin followed by an early decrease in blood glucose compared with SG group. Expression levels of glucose transporter 1 (GLUT1) and sodium-glucose cotransporter 1 (SGLT1) mRNA and protein in the alimentary limb (AL) were greater in the SG-DJB group than in the SG group. The additional effects of duodenojejunal bypass on glucose metabolism after SG may be related to increased expression of GLUT1 and SGLT1 in the AL.

Academic Significance and Societal Importance of the Research Achievements

わが国では2014年4月腹腔鏡下スリーブ状胃切除術(SG)が保険収載され、2018年4月に腹腔鏡下スリーブバイパス術(SG-DJB)が先進医療として承認されている。またわが国のデータでも重症の糖尿病患者に対してはSGよりもSG-DJBの方が糖尿病の改善効果は高いことが示されている。今回の検討では動物実験レベルではあるが、SGに十二指腸空腸バイパス術を加えることで糖代謝改善の上乗せ効果があることが明らかになり、さらにそのメカニズムとして食物脚のグルコーストランスポーター活性化が関与していることが示された。本研究結果により、今後さらにSG-DJBの普及がわが国で進むことが期待される

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (42 results)

All 2019 2018 2017 2016

All Journal Article (11 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 6 results,  Open Access: 2 results) Presentation (28 results) (of which Int'l Joint Research: 14 results,  Invited: 1 results) Book (3 results)

  • [Journal Article] Additional effects of duodenojejunal bypass on glucose metabolism in a rat model of sleeve gastrectomy.2019

    • Author(s)
      Takayama H, Ohta M, Tada K, Watanabe K, Kawasaki T, Endo Y, Iwashita Y, Inomata M.
    • Journal Title

      Surg Today

      Volume: aheadofprint Issue: 7 Pages: 637-644

    • DOI

      10.1007/s00595-019-1772-x

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bariatric/metabolic surgery in the Asia-Pacific region: APMBSS 2018 survey.2019

    • Author(s)
      Ohta M, Seki Y, Wong SK, Wang C, Huang CK, Aly A, Baijal M, Al-Sabah S, Udomsawaengsup S, Heo YS, Althuwaini SS, Celik A, El-Hadidi N, Sargsyan D, Gee T, Rao J, Wiradisuria ER, Oliveros E, Kitano S, Kasama K.
    • Journal Title

      Obes Surg

      Volume: 29(2) Issue: 2 Pages: 534-541

    • DOI

      10.1007/s11695-018-3539-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Clinical significance of upper gastrointestinal endoscopy before laparoscopic bariatric procedures in Japanese patients.2019

    • Author(s)
      Endo Y, Ohta M, Tada K, Saga K, Takayama H, Hirashita T, Uchida H, Iwashita Y, Inomata M.
    • Journal Title

      Surg Today

      Volume: 49(1) Issue: 1 Pages: 27-31

    • DOI

      10.1007/s00595-018-1705-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy of Sleeve Gastrectomy with Duodenal-Jejunal Bypass for the Treatment of Obese Severe Diabetes Patients in Japan: a Retrospective Multicenter Study.2018

    • Author(s)
      Naitoh T, Kasama K, Seki Y, Ohta M, Oshiro T, Sasaki A, Miyazaki Y, Yamaguchi T, Hayashi H, Imoto H, Tanaka N, Unno M.
    • Journal Title

      Obes Surg.

      Volume: 28 Issue: 2 Pages: 497-505

    • DOI

      10.1007/s11695-017-2874-4

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of sleeve gastrectomy on nonalcoholic fatty liver disease in an obese rat model2018

    • Author(s)
      Watanabe K, Ohta M, Takayama H, Tada K, Shitomi Y, Kawasaki T, Kawano Y, Endo Y, Iwashita Y, Inomata M
    • Journal Title

      Obes Surg

      Volume: 28(6) Issue: 6 Pages: 1532-1539

    • DOI

      10.1007/s11695-017-3052-4

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 肥満外科手術の現状2017

    • Author(s)
      太田正之,遠藤裕一,猪股雅史
    • Journal Title

      日本医事新報

      Volume: 4855 Pages: 40-45

    • NAID

      40021183774

    • Related Report
      2017 Research-status Report
  • [Journal Article] 肥満の外科療法2017

    • Author(s)
      太田正之,遠藤裕一,髙山洋臣,嵯峨邦裕,多田和裕,猪股雅史
    • Journal Title

      成人病と生活習慣病

      Volume: 47(11) Pages: 1448-1451

    • Related Report
      2017 Research-status Report
  • [Journal Article] 高度肥満症に対する肥満外科手術2017

    • Author(s)
      遠藤裕一,太田正之,猪股雅史
    • Journal Title

      診断と治療

      Volume: 105 Pages: 350-355

    • Related Report
      2016 Research-status Report
  • [Journal Article] Long-term outcomes of bariatric and metabolic surgery in Japan: Results of a multi-institutional survey2016

    • Author(s)
      Haruta H, Kasama K, Ohta M, Sasaki A, Yamamoto H, Miyazaki Y, Oshiro T, Naitoh T, Hosoya Y, Togawa T, Seki Y, Lefor AK, Tani T
    • Journal Title

      Obesity Surgery

      Volume: 27(3) Issue: 3 Pages: 754-762

    • DOI

      10.1007/s11695-016-2361-3

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] スリーブ状胃切除術の糖代謝や摂食中枢に与える影響2016

    • Author(s)
      太田正之,遠藤裕一,川崎貴秀,渡邉公紀,髙山洋臣,嵯峨邦裕,猪股雅史
    • Journal Title

      外科と代謝・栄養

      Volume: 50 Pages: 223-228

    • NAID

      130005290575

    • Related Report
      2016 Research-status Report
  • [Journal Article] 糖尿病と肥満外科手術 肥満外科手術はどのくらい血糖コントロールを改善させるか2016

    • Author(s)
      太田正之,遠藤裕一,髙山洋臣,嵯峨邦裕,猪股雅史
    • Journal Title

      糖尿病診療マスター

      Volume: 14 Pages: 255-259

    • Related Report
      2016 Research-status Report
  • [Presentation] Oral:Comparison between ABCD and IMS scores in prediction of long-term T2DM remission after sleeve gastrectomy2019

    • Author(s)
      Ohta M, Endo Y, Tada K, Saga K, Hirashita T, Masuda T, Iwashita Y, Inomata M
    • Organizer
      IFSO-APC 2019、広州、中国
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Symposium:The Japanese Report2019

    • Author(s)
      Ohta M
    • Organizer
      IFSO-APC 2019、広州、中国
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Symposium:Japanese experience in laparoscopic adjustable gastric banding2018

    • Author(s)
      Ohta M, Endo Y, Takayama H, Tada K, Saga K, Hirashita T, Uchida H, Iwashita Y, Inomata M, Kitano S
    • Organizer
      Asia-Pacific Metabolic and Bariatric Surgery Society Congress 2018、東京
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Symposium:Endoscopic intragastric balloon placement in Japan: Results of national survey 20162018

    • Author(s)
      Ohta M, Endo Y, Inomata M, Kitano S
    • Organizer
      Asia-Pacific Metabolic and Bariatric Surgery Society Congress 2018、東京
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 市民公開講座:肥満症治療の最前線-肥満外科治療ってなに?2018

    • Author(s)
      太田正之
    • Organizer
      第36回日本肥満症治療学会学術集会、東京
    • Related Report
      2018 Annual Research Report
  • [Presentation] ビデオシンポジウム:腹腔鏡下スリーブ状胃切除術後の食道裂孔ヘルニアと逆流性食道炎の変化の検討2018

    • Author(s)
      太田正之,遠藤裕一,髙山洋臣,多田和裕,嵯峨邦裕,平下禎二郎,内田博喜,岩下幸雄,猪股雅史
    • Organizer
      第73回日本消化器外科学会総会、鹿児島
    • Related Report
      2018 Annual Research Report
  • [Presentation] Poster:FXR pathway expression and nonalcoholic fatty liver disease in a rat sleeve model2018

    • Author(s)
      Ohta M, Endo Y, Watanabe K, Tada K, Saga K, Hirashita T, Iwashita Y, Uchida H, Inomata M
    • Organizer
      IFSO 2018、ドバイ、UAE
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Poster:Predictive factor for insufficient weight loss 2 years after laparoscopic sleeve gastrectomy?2018

    • Author(s)
      Ohta M, Endo Y, Tada K, Saga K, Hirashita T, Iwashita Y, Uchida H, Inomata M
    • Organizer
      IFSO 2018、ドバイ、UAE
    • Related Report
      2018 Annual Research Report
    • Int'l Joint Research
  • [Presentation] シンポジウム:肥満・糖尿病外科手術のアジア太平洋諸国とわが国の現状2018

    • Author(s)
      太田正之,遠藤裕一,多田和裕,関 洋介,笠間和典,猪股雅史,北野正剛
    • Organizer
      第31回日本内視鏡外科学会総会、福岡
    • Related Report
      2018 Annual Research Report
  • [Presentation] Japanese experience in laparoscopic adjustable gastric banding2018

    • Author(s)
      Ohta M, Endo Y, Takayama H, Tada K, Saga K, Hirashita T, Uchida H, Iwashita Y, Inomata M, Kitano S
    • Organizer
      Asia-Pacific Metabolic and Bariatric Surgery Society Congress 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] Endoscopic intragastric balloon placement in Japan: Results of national survey 20162018

    • Author(s)
      Ohta M, Endo Y, Inomata M, Kitano S
    • Organizer
      Asia-Pacific Metabolic and Bariatric Surgery Society Congress 2018
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] サージカルフォーラム:スリーブ状胃切除術後の糖尿病寛解予測にABCDスコアとDiaRemスコアはどちらが有用か?2017

    • Author(s)
      太田正之,遠藤裕一,髙山洋臣,嵯峨邦裕,多田和裕,岩下幸雄,内田博喜,平下禎二郎,猪股雅史
    • Organizer
      第117回日本外科学会定期学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 一般演題:肥満・糖尿病外科手術前の上部消化管内視鏡検査の意義2017

    • Author(s)
      太田正之,遠藤裕一,髙山洋臣,嵯峨邦裕,多田和裕,岩下幸雄,内田博喜,平下禎二郎,猪股雅史
    • Organizer
      第93回日本消化器内視鏡学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 特別企画2:難治性高度肥満患者の予測因子の検討2017

    • Author(s)
      太田正之,遠藤裕一,髙山洋臣,多田和裕,正木孝幸,猪股雅史,北野正剛
    • Organizer
      第35回日本肥満症治療学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 一般口演:腹腔鏡下調節性胃バンド術後のスリーブ状胃切除術(revision surgery)2017

    • Author(s)
      太田正之,遠藤裕一,髙山洋臣,多田和裕,嵯峨邦裕,平下禎二郎、内田博喜,岩下幸雄,猪股雅史
    • Organizer
      第42回日本外科系連合学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] DiaRem score is a good predictors of diabetes remission after laparoscopic sleeve gastrectomy for Japanese obese patients2017

    • Author(s)
      Ohta M, Endo Y, Hirashita T, Iwashita Y, Uchida H, Inomata M
    • Organizer
      22th World Congress of International Federation for the Surgery of Obesity & Metabolic Disorders
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] What is a good predictor of 2-year weight loss after laparoscopic sleeve gastrectomy?2017

    • Author(s)
      Ohta M, Endo Y, Hirashita T, Iwashita Y, Uchida H, Inomata M
    • Organizer
      22th World Congress of International Federation for the Surgery of Obesity & Metabolic Disorders
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] 一般演題(ポスター): DiaRemスコアのスリーブ状胃切除術後の糖尿病寛解予測に関する検討2017

    • Author(s)
      太田正之,遠藤裕一,髙山洋臣,多田和裕,猪股雅史
    • Organizer
      第38回日本肥満学会
    • Related Report
      2017 Research-status Report
  • [Presentation] ランチョンセミナー:肥満・2型糖尿病に対する外科治療の効果と実際2017

    • Author(s)
      太田正之
    • Organizer
      第38回日本肥満学会
    • Related Report
      2017 Research-status Report
    • Invited
  • [Presentation] Comparison of ABCD score with DiaRem score in type 2 diabetes remission after laparoscopic sleeve gastrectomy2017

    • Author(s)
      Ohta M, Endo Y, Takayama H, Tada K, Saga K, Iwashita Y, Uchida H, Hirashita T, Inomata M
    • Organizer
      13th Asia-Pacific Congress of the Endoscopic andLaparoscopic Surgeons of Asia
    • Related Report
      2017 Research-status Report
    • Int'l Joint Research
  • [Presentation] シンポジウム:肥満・糖尿病外科手術の適応と術式選択2017

    • Author(s)
      太田正之,遠藤裕一,髙山洋臣,多田和裕,嵯峨邦裕,岩下幸雄,内田博喜,平下禎二郎,猪股雅史
    • Organizer
      第30回日本内視鏡外科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] Which is a better predictor of diabetes remission after laparoscopic sleeve gastrectomy for Japanese patients; ABCD score or DiaRem score?2016

    • Author(s)
      Ohta M, Endo Y, Hirashita T, Iwashita Y, Uchida H, Inomata M
    • Organizer
      21th World Congress of International Federation for the Surgery of Obesity & Metabolic Disorders
    • Place of Presentation
      Winsor Barra, Rio de Janeiro, Brazil
    • Year and Date
      2016-09-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Changes in serum uric acid after laparoscopic sleeve gastrectomy for Japanese obese patients2016

    • Author(s)
      Ohta M, Endo Y, Hirashita T, Iwashita Y, Uchida H, Inomata M
    • Organizer
      21th World Congress of International Federation for the Surgery of Obesity & Metabolic Disorders
    • Place of Presentation
      Winsor Barra, Rio de Janeiro, Brazil
    • Year and Date
      2016-09-28
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] ワークショップ:わが国における腹腔鏡下肥満外科手術の現状と問題点2016

    • Author(s)
      太田正之,遠藤裕一,髙山洋臣,嵯峨邦裕,多田和裕,岩下幸雄,内田博喜,平下禎二郎,猪股雅史,北野正剛
    • Organizer
      第29回日本内視鏡外科学会総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Related Report
      2016 Research-status Report
  • [Presentation] シンポジウム:わが国における肥満・糖尿病外科手術の現状2016

    • Author(s)
      太田正之,遠藤裕一,猪股雅史,北野正剛
    • Organizer
      第78回日本臨床外科学会総会
    • Place of Presentation
      グランドプリンスホテル新高輪(東京都港区)
    • Related Report
      2016 Research-status Report
  • [Presentation] Combination method of laparoscopic sleeve gastrectomy with cholecystectomy2016

    • Author(s)
      Ohta M, Endo Y, Takayama H, Saga K, Tada K, Hirashita T, Uchida H, Iwashita Y, Inomata M, Kitano S
    • Organizer
      Asian Pacific Digestive Week (APDW) 2016
    • Place of Presentation
      神戸コンべンションセンター(兵庫県神戸市)
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] シンポジウム: Is the DiaRem score a useful predictor of diabetes remission after laparoscopic sleeve gastrectomy?2016

    • Author(s)
      太田正之,遠藤裕一,岩下幸雄,矢田一宏,内田博喜,猪股雅史,北野正剛
    • Organizer
      第71回日本消化器外科学会総会
    • Place of Presentation
      アスティ徳島(徳島県徳島市)
    • Related Report
      2016 Research-status Report
  • [Presentation] 腹腔鏡下スリーブ状胃切除術100例の検討2016

    • Author(s)
      太田正之,遠藤裕一,髙山洋臣,猪股雅史,北野正剛
    • Organizer
      第34回日本肥満症治療学会学術集会
    • Place of Presentation
      東京コンべンションホール(東京都中央区)
    • Related Report
      2016 Research-status Report
  • [Book] 肥満・糖尿病の外科治療 第1章 肥満症患者の病態と治療の基本 5 肥満症の治療:外科治療の位置づけ2017

    • Author(s)
      遠藤裕一,太田正之,猪股雅史,北野正剛
    • Publisher
      メディカ出版
    • Related Report
      2017 Research-status Report
  • [Book] 肥満・糖尿病の外科治療 第2章 肥満・糖尿病外科治療総論 2 肥満適応と種類2017

    • Author(s)
      太田正之,遠藤裕一,猪股雅史
    • Publisher
      メディカ出版
    • Related Report
      2017 Research-status Report
  • [Book] Annual Review 2016 消化器 Ⅳ消化器外科-5 肥満外科手術とメタボリックサージェリーUp-to-date2016

    • Author(s)
      遠藤裕一,太田正之,猪股雅史
    • Publisher
      中外医学社
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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