Search for N-type sugar chain markers that enable personalized treatment and prognosis for esophageal cancer
Project/Area Number |
16K10510
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Kagoshima University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
佐々木 健 鹿児島大学, 医歯学域附属病院, 助教 (00418849)
喜多 芳昭 鹿児島大学, 医歯学域附属病院, 助教 (30570692)
大脇 哲洋 鹿児島大学, 医歯学域医学系, 教授 (50322318)
夏越 祥次 鹿児島大学, 医歯学域医学系, 教授 (70237577)
尾本 至 鹿児島大学, 附属病院, 医員 (90721217)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Project Status |
Completed (Fiscal Year 2018)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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Keywords | 食道癌 / 個別化治療 / N型糖鎖 / *食道癌 / N型糖鎖 |
Outline of Final Research Achievements |
We focused on N-glycans in plasma that distinguish between esophageal cancer patients and healthy individuals.We investigated whether we could predict the effect on the treatment of esophageal cancer patients. The N-glycans in the plasma of 48 patients with esophageal cancer were measured. As a result, we found sugar chains that changed before and after surgery, before and after radical chemoradiotherapy, and with or without therapeutic effects. Moreover, as a result of examining the biopsy sample of the endoscopy before treatment, the esophageal cancer causing the epithelial-mesenchymal transition had a poor therapeutic effect. The presence or absence of micrometastases in the dissected lymph nodes was associated with therapeutic effects. In other words, it was suggested that changes in sugar chains could be predictive of effects.
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Academic Significance and Societal Importance of the Research Achievements |
食道癌患者に対する治療の前後で血漿中のN型糖鎖の変化を測定することができた。実際に治療効果で変化のある糖鎖も指摘できたことで、どの糖鎖の組み合わせがより治療効果を反映しているかを判定し、治療前の生検での免疫生化学検査も組み合わせることにより、今後、食道道癌患者の治療を行うにあたり、血液検査によって、治療前に効果をより正確に予測することが可能となる。
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Molecular pathogenesis of esophageal squamous cell carcinoma: Identification of the antitumor effects of miR 145 3p on gene regulation.2019
Author(s)
Shimonosono M, Idichi T, Seki N, Yamada Y, Arai T, Arigami T, Sasaki K, Omoto I, Uchikado Y, Kita Y, Kurahara H, Maemura K, Natsugoe S.
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Journal Title
Int J Oncol.
Volume: 54
Pages: 673-688
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Expression of SOX9 Is Related to Prognosis in Patients with Oesophageal Squamous Cell Carcinoma.2018
Author(s)
Higo N, Okumura H, Uchikado Y, Omoto I, Sasaki K, Kita Y, Ryosuke D, Noda M, Owaki T, Ishigami S, Natsugoe S.
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Journal Title
In Vivo
Volume: 32
Issue: 4
Pages: 835-838
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Filamin C promotes lymphatic invasion and lymphatic metastasis and increases cell motility by regulating Rho GTPase in esophageal squamous cell carcinoma.2017
Author(s)
Tanabe K, Shinsato Y, Furukawa T, Kita Y, Hatanaka K, Minami K, Kawahara K, Yamamoto M, Baba K, Mori S, Uchikado Y, Maemura K, Tanimoto A, Natsugoe S.
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Journal Title
Oncotarget.
Volume: 8
Issue: 4
Pages: 6353-6363
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] As a Novel Prognostic Marker, Cysteine/histidine-rich 1 (CYHR1) is a Therapeutic Target in Patients with Esophageal Squamous Cell Carcinoma.2015
Author(s)
Desaki R, Sawada G, Okumura H, Ikeda R, Tanabe K, Komatsu H, Mimori K, Mori M, Kita Y, Uchikado Y, Arigami T, Uenosono Y, Owaki T, Ishigami S, Natsugoe S.
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Journal Title
Ann Surg Oncol.
Volume: Epub
Issue: 2
Pages: 586-593
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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