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PD-L1 expression in GI cancer and Immune checkpoint inhibitor

Research Project

Project/Area Number 16K10511
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionFukushima Medical University

Principal Investigator

Kono Koji  福島県立医科大学, 医学部, 教授 (40283204)

Co-Investigator(Kenkyū-buntansha) 中島 隆宏  福島県立医科大学, 医学部, 博士研究員 (90567447)
Project Period (FY) 2016-04-01 – 2020-03-31
Project Status Completed (Fiscal Year 2019)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords免疫チェックポイント阻害 / 消化器癌 / Nivolmab / PD-L1 / 免疫チェックポイント阻害剤 / 消化器がん / 免疫チェックポイント / 免疫チョックポイント阻害剤 / IFN-gamma / 癌免疫療法 / PDL1 / PD1
Outline of Final Research Achievements

(I)PD-L1 is upregulated by IFN-g through JAK-STAT pathway in GI-tract cancer.(II)There is a positive correlation between EMT status and PD-L1 expression in GI tract cancer.(III)microRNA from tumor microenvironment can down-regulate PD-L1 expression in colon cancer

Academic Significance and Societal Importance of the Research Achievements

消化器癌におけるPD-L1の発現調節機構を解明することで、免疫チェックポイント阻害剤の効果増強、ResponderのPrediction、Non-responderの機序解明に寄与できる。

Report

(5 results)
  • 2019 Annual Research Report   Final Research Report ( PDF )
  • 2018 Research-status Report
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (6 results)

All 2019 2018 2017 2016

All Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Open Access: 4 results) Presentation (2 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] microRNA-148a-3p regulates immunosuppression in DNA mismatch repair-deficient colorectal cancer by targeting PD-L12019

    • Author(s)
      Ashizawa Mai、Okayama Hirokazu、Ishigame Teruhide、Thar Min Aung Kyi、Saito Katsuharu、Ujiie Daisuke、Murakami Yuko、Kikuchi Tomohiro、Nakayama Yuko、Noda Masaru、Tada Takeshi、Endo Hisahito、Fujita Shotaro、Sakamoto Wataru、Saito Motonobu、Saze Zenichiro、Momma Tomoyuki、Ohki Shinji、Mimura Kosaku、Kono Koji
    • Journal Title

      Molecular Cancer Research

      Volume: Epub ahead of print Issue: 6 Pages: 1403-1413

    • DOI

      10.1158/1541-7786.mcr-18-0831

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Phospho-STAT1 expression as a potential biomarker for ant-PD-1/anti-PD-L1 immunotherapy for breast cancer.2019

    • Author(s)
      Nakayama Y, Mimura K, Tamaki T, Shiraishi K, Kua LF, Koh V, Ohmori M, Kimura A, Inoue S, Okayama H, Suzuki Y, Nakazawa T, Ichikawa D, Kono K.
    • Journal Title

      Int J Oncol.

      Volume: 54 Pages: 2030-2038

    • DOI

      10.3892/ijo.2019.4779

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] PD-L1 expression is mainly regulated by IFN-γ associated with JAK-STAT pathway in gastric cancer2018

    • Author(s)
      Mimura Kousaku, TEH Jun, Okayama Hirokazu, Shiraishi Kensuke, Kua Ley-Fang, Koh Vivien, Smoot Duane T, Ashktorab Hassan, Oike Takahiro, Suzuki Yoshiyuki, Fazreen Zul, Asuncion Bernadette, Shabbir Asim, Yong Wei Peng, So Jimmy, Soong Richie and Kono, Koji.
    • Journal Title

      Cancer Science

      Volume: 109 Pages: 43-53

    • Related Report
      2018 Research-status Report 2017 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epithelial-mesenchymal transition-converted tumor cells can induce T-cell apoptosis through upregulation of programmed death ligand 1 expression in esophageal squamous cell carcinoma2018

    • Author(s)
      15.Thar Min AK, Okayama H, Saito M, Ashizawa M, Aoto K, Nakajima T, Saito K, Hayase S, Sakamoto W, Tada T, Hanayama H, Saze Z, Momma T, Ohki S, Sato Y, Motoyama S, Mimura K, Kono K.
    • Journal Title

      Cancer Medicine

      Volume: 7 Pages: 3321-3330

    • NAID

      120007126995

    • Related Report
      2018 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 消化器癌におけるPD-L1発現調節機構の解明2017

    • Author(s)
      三村耕作、河野浩二
    • Organizer
      日本外科学会
    • Place of Presentation
      横浜
    • Year and Date
      2017-04-26
    • Related Report
      2016 Research-status Report
  • [Presentation] Regulatry mechanisms of PD-L1 on GI cancer2016

    • Author(s)
      Koji KONO
    • Organizer
      2017 annual meeting of Singapore Gastric Cancer Consocium
    • Place of Presentation
      Singapore
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research / Invited

URL: 

Published: 2016-04-21   Modified: 2021-02-19  

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