| Project/Area Number |
16K10532
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Mie University |
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Principal Investigator |
Saigusa Susumu 三重大学, 医学系研究科, リサーチアソシエイト (10632383)
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| Co-Investigator(Kenkyū-buntansha) |
問山 裕二 三重大学, 医学部附属病院, 准教授 (00422824)
田中 光司 三重大学, 医学系研究科, 客員准教授 (10345986)
楠 正人 三重大学, 医学系研究科, 教授 (50192026)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2018: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 直腸癌 / 間質 / バイオマーカー / 術前化学放射線療法 / 再発マーカー / 化学放射線療法 / 再発 / 予後 / 癌間質 / 放射線化学療法 / 治療抵抗性 |
|---|
| Outline of Final Research Achievements |
Immunohistochemical analysis showed that elevated PD-L1 expression in rectal cancer tissues was significantly correlated with presence of lymphovascular invasion and recurrence after curative surgery. Survival curve analysis demonstrated that elevated PD-L1 expression was significantly correlated with poor overall and disease-free survival in rectal cancer patients receiving chemoradiotherapy. Furthermore, number of CD8+ tumor infiltrative lymphocytes (TILs) was positively correlated with FOXP3+ TILs, and CD8+ TILs was significantly increased in patients with high PD-L1 expression.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究結果を用いることで、直腸癌化学放射線療法におけるあらたな予後マーカーとなるほか、免疫チェックポイント阻害剤併用の可能性が考慮された。
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