| Project/Area Number |
16K10533
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Mie University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
問山 裕二 三重大学, 医学部附属病院, 准教授 (00422824)
井上 靖浩 三重大学, 医学系研究科, 客員准教授 (20324535)
楠 正人 三重大学, 医学系研究科, 教授 (50192026)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2017: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 大腸癌 / PD-１ / PD-L1 / 遺伝子解析 / マイクロサテライト不安定性 / 腫瘍浸潤Ｔリンパ球 / バイオマーカー / 免疫療法 |
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| Outline of Final Research Achievements |
The aim of this study was to clarify clinical burden of PD-1-PD-L1 axis in colorectal cancer patients. Interesting, elevated expression of PD-L1 was significantly correlated with poor overall survival and disease-free survival in CRC patients. Furthermore, assessment od CTLA4 concentration in preoperative serum could also identify high-risk population for recurrence and survival in CRC.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究結果を用いることで、あらたな予後予測マーカーとなりうるほか、免疫チェックポイント阻害剤の効果予測因子となる可能性が示唆された。
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