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Local anatomy of rectum and functional evaluation after rectal cancer surgery

Research Project

Project/Area Number 16K10538
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionKyoto University

Principal Investigator

Hida Koya  京都大学, 医学研究科, 助教 (40447983)

Project Period (FY) 2016-10-21 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2017: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2016: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords直腸癌 / 腹腔鏡下手術 / 大腸癌 / .直腸癌 / 機能評価 / データベース / 外科学
Outline of Final Research Achievements

A multi institute study on the urinary, sexual and defecate function after rectal cancer surgery was conducted, and the results of two year follow up data were reported. About the prognosis of rectal cancer, we analyzed the factors of local recurrence and reported the results of an international collaborate study with Korea in 2017. The relationship between sensitivity and specificity was investigated for the diagnosis of pelvic MRI. The anatomy of the pelvis was visualized by 3D construction of pelvic muscles using cadaver. In addition, we reported a review on the usefulness of Goshajinki-gan to prevent the adverse effects of chemotherapy for colon cancer. A new surveillance strategy categorized by cancer stage was also reported as a useful method.

Academic Significance and Societal Importance of the Research Achievements

直腸癌術後の機能に関しては、QOLの低下が、癌の根治とどこまで両立するかが永遠の課題でありその具体的な経過を報告したことは患者本人の治療方針決定に大きなサポートなると考えられる。また、直腸癌の術後再発の可能性が高くなる因子を抽出することで、個別化された術後の経過観察の重要性を認識することが可能となる。術前MRIの診断能に関しては術前評価の可能性を認識し、骨盤筋肉の3D再構築により手術のナビゲーションが可能となってくる。術後のサーベイランスに関しては、論文が大腸癌治療ガイドラインにも引用され、大腸癌治療に大きな一石を投じることとなった。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2019 2018 2017 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Peer Reviewed: 5 results) Presentation (2 results)

  • [Int'l Joint Research] Kyungpook National University(韓国)

    • Related Report
      2018 Annual Research Report
  • [Journal Article] Short-term outcomes of laparoscopic surgery for colorectal cancer in the elderly versus non-elderly: a systematic review and meta-analysis2019

    • Author(s)
      Hoshino Nobuaki、Fukui Yudai、Hida Koya、Sakai Yoshiharu
    • Journal Title

      International Journal of Colorectal Disease

      Volume: 34 Issue: 3 Pages: 377-386

    • DOI

      10.1007/s00384-019-03234-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Proposal of a stage-specific surveillance strategy for colorectal cancer patients: A retrospective analysis of Japanese large cohort2018

    • Author(s)
      Okamura Ryosuke、Hida Koya、Nishizaki Daisuke、Sugihara Kenichi、Sakai Yoshiharu
    • Journal Title

      European Journal of Surgical Oncology

      Volume: 44 Issue: 4 Pages: 449-455

    • DOI

      10.1016/j.ejso.2018.01.080

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Goshajinkigan for reducing chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis2018

    • Author(s)
      Hoshino Nobuaki、Ganeko Riki、Hida Koya、Sakai Yoshiharu
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 23 Issue: 3 Pages: 434-442

    • DOI

      10.1007/s10147-017-1229-4

    • Related Report
      2018 Annual Research Report 2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] Diagnostic accuracy of magnetic resonance imaging and computed tomography for lateral lymph node metastasis in rectal cancer: a systematic review and meta-analysis2018

    • Author(s)
      Hoshino Nobuaki、Murakami Katsuhiro、Hida Koya、Sakamoto Takashi、Sakai Yoshiharu
    • Journal Title

      International Journal of Clinical Oncology

      Volume: 24 Issue: 1 Pages: 46-52

    • DOI

      10.1007/s10147-018-1349-5

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A New Prediction Model for Local Recurrence After Curative Rectal Cancer Surgery2017

    • Author(s)
      Hida Koya、Okamura Ryosuke、Park Soo Yeun、Nishigori Tatsuto、Takahashi Ryo、Kawada Kenji、Choi Gyu-Seog、Sakai Yoshiharu
    • Journal Title

      Diseases of the Colon & Rectum

      Volume: 60 Issue: 11 Pages: 1168-1174

    • DOI

      10.1097/dcr.0000000000000896

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Presentation] 多施設共同前向きデータにみる腹腔鏡下直腸癌術後肛門機能の2年経時的変化2018

    • Author(s)
      奥村公一
    • Organizer
      日本外科学会総会
    • Related Report
      2017 Research-status Report
  • [Presentation] 直腸癌術後における排尿機能障害の検討2018

    • Author(s)
      村上克宏
    • Organizer
      日本外科学会総会
    • Related Report
      2017 Research-status Report

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Published: 2016-10-24   Modified: 2020-03-30  

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