Identification of novel therapeutic target genes based on genomic progression model of colorectal cancer

• Project/Area Number: 16K10543
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: Masuda Takaaki 九州大学, 大学病院, 講師 (50463493)
• Co-Investigator(Kenkyū-buntansha): 三森 功士 九州大学, 大学病院, 教授 (50322748)
• Co-Investigator(Renkei-kenkyūsha): Niida Atsushi ; Suzuki Yutaka
• Project Period (FY): 2016-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 大腸癌 / 分子治療標的 / ゲノム進化 / がん遺伝子 / ゲノム進化モデル / 腫瘍多様性 / 7番染色体 / 13番染色体 / 腫瘍内不均一性 / 分子標的遺伝子

Outline of Final Research Achievements

Tumor heterogeneity is a major cause of the therapeutic difficulty of cancer due to the presence of multiple subclones boosting adaptation to pharmacologic interventions. We found several oncogenes as a potential therapeutic target in colorectal cancer to overcome the therapeutic resistance conferred by tumor heterogeneity.

Academic Significance and Societal Importance of the Research Achievements

がん治療を困難としているがんの多様性に影響を受けない有効な治療標的となりうる遺伝子を複数同定しえた。現在それら遺伝子を標的とする治療薬（化合物）を開発を試みている。これらの成果はがん治療成績の向上に寄与するものと期待される。

Research Products

• [Journal Article] A clinical trial of somatic and germline analyses for healthy longevity in a postoperative cancer patient. (2019)
  • Author(s): Hayashi N, Kuroda Y, Saito T, Tsuruda Y, Niida A, Otsu H, Eguchi H, Masuda T, Suzuki Y, Natsugoe S, Mimori K.
  • Journal Title: Surg Today. Volume: Epub Issue: 9 Pages: 738-747
  • DOI: 10.1007/s00595-019-01789-7
  • Peer Reviewed / Open Access
• [Journal Article] CRMP5-associated GTPase (CRAG) Is a Candidate Driver Gene for Colorectal Cancer Carcinogenesis. (2019)
  • Author(s): Shimizu D, Masuda T, Sato K, Tsuruda Y, Otsu H, Kuroda Y, Eguchi H, Kodera Y, Mimori K.
  • Journal Title: Anticancer Res. Volume: 39(1) Issue: 1 Pages: 99-106
  • DOI: 10.21873/anticanres.13084
  • Peer Reviewed / Open Access
• [Journal Article] Multiregion Genomic Analysis of Serially Transplanted Patient-derived Xenograft Tumors. (2019)
  • Author(s): Sato K, Niida A, Masuda T, Shimizu D, Tobo T, Kuroda Y, Eguchi H, Nakagawa T, Suzuki Y, Mimori K.
  • Journal Title: Cancer Genomics Proteomics. Volume: 16(1) Issue: 1 Pages: 21-27
  • DOI: 10.21873/cgp.20109
  • Peer Reviewed / Open Access
• [Journal Article] Cytolytic Activity (CYT) Score Is a Prognostic Biomarker Reflecting Host Immune Status in Hepatocellular Carcinoma (HCC). (2018)
  • Author(s): Wakiyama H, Masuda T, Motomura Y, Hu Q, Tobo T, Eguchi H, Sakamoto K, Hirakawa M, Honda H, Mimori K.
  • Journal Title: Anticancer Res Volume: 38(12) Issue: 12 Pages: 6631-6638
  • DOI: 10.21873/anticanres.13030
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Impact of Immune-Related Gene Expression in Preoperative Peripheral Blood from Gastric Cancer Patients (2018)
  • Author(s): Shuhei Ito et al
  • Journal Title: Ann Surg Oncol Volume: 25 Issue: 12 Pages: 3755-3763
  • DOI: 10.1245/s10434-018-6739-4
  • Peer Reviewed / Open Access
• [Journal Article] Serial mutational tracking in surgically resected locally advanced colorectal cancer with neoadjuvant chemotherapy. (2018)
  • Author(s): Sugimachi K, Sakimura S, Kuramitsu S, Hirata H, Niida A, Iguchi T, Eguchi H, Masuda T, Morita M, Toh Y, Maehara Y, Suzuki Y, Mimori K.
  • Journal Title: Br J Cancer. Volume: 4 Issue: 4 Pages: 419-423
  • DOI: 10.1038/s41416-018-0208-5
  • Peer Reviewed / Open Access
• [Journal Article] Circulating Pre-microRNA-488 in Peripheral Blood Is a Potential Biomarker for Predicting Recurrence in Breast Cancer. (2018)
  • Author(s): Masuda T, Shinden Y, Noda M, Ueo H, Hu Q, Yoshikawa Y, Tsuruda Y, Kuroda Y, Ito S, Eguchi H, Ohno S, Mimori K.
  • Journal Title: Anticancer Res. Volume: 38(8) Issue: 8 Pages: 4515-4523
  • DOI: 10.21873/anticanres.12755
  • Peer Reviewed / Open Access
• [Journal Article] A temporal shift of the evolutionary principle shaping intratumor heterogeneity in colorectal cancer (2018)
  • Author(s): Saito T, Niida A, Uchi R, Hirata H, Kodama M, Okimoto T, Murakami K, Suzuki Y, Ogawa S, Miyano S, Mimori K, et al.
  • Journal Title: Nature Communications Volume: 9 Issue: 1 Pages: 2884-2884
  • DOI: 10.1038/s41467-018-05226-0
  • NAID: 120006551763
  • Peer Reviewed / Open Access
• [Journal Article] Over expression of FGFR1 Promotes Peritoneal Dissemination Via Epithelial-to-Mesenchymal Transition in Gastric Cancer. (2018)
  • Author(s): Shimizu D, Saito T, Ito S, Masuda T, Kurashige J, Kuroda Y, Eguchi H, Kodera Y, Mimori K.
  • Journal Title: Cancer Genomics Proteomics. Volume: 15(4) Issue: 4 Pages: 313-320
  • DOI: 10.21873/cgp.20089
  • Peer Reviewed / Open Access
• [Journal Article] Identification of UHRF2 as a Negative Regulator of Epithelial-Mesenchymal Transition and Its Clinical Significance in Esophageal Squamous Cell Carcinoma. (2018)
  • Author(s): Iguchi T, Ueda M, Masuda T, Nambara S, Kidogami S, Komatsu H, Sato K, Tobo T, Ogawa Y, Hu Q, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Maehara Y, Mimori K
  • Journal Title: Oncology Volume: 3 Issue: 3 Pages: 179-187
  • DOI: 10.1159/000488860
  • Peer Reviewed / Open Access
• [Journal Article] Identification of ARL4C as a Peritoneal Dissemination-Associated Gene and Its Clinical Significance in Gastric Cancer. (2018)
  • Author(s): Hu Q, Masuda T, Sato K, Tobo T, Nambara S, Kidogami S, Hayashi N, Kuroda Y, Ito S, Eguchi H, Saeki H, Oki E, Maehara Y, Mimori K
  • Journal Title: Ann Surg Oncol Volume: 25(3) Issue: 3 Pages: 745-753
  • DOI: 10.1245/s10434-017-6292-6
  • Peer Reviewed / Open Access
• [Journal Article] Antitumor effects of the antiparasitic agent ivermectin via inhibition of Yes-associated protein 1 expression in gastric cancer. (2017)
  • Author(s): Nambara S, Masuda T, Nishio M, Kuramitsu S, Tobo T, Ogawa Y, Hu Q, Iguchi T, Kuroda Y, Ito S, Eguchi H, Sugimachi K, Saeki H, Oki E, Maehara Y, Suzuki A, Mimori K
  • Journal Title: Oncotarget. Volume: 8(64) Issue: 64 Pages: 107666-107677
  • DOI: 10.18632/oncotarget.22587
  • NAID: 120006454566
  • Peer Reviewed / Open Access
• [Journal Article] Circulating exosomal microRNA-203 is associated with metastasis possibly via inducing tumor-associated macrophages in colorectal cancer (2017)
  • Author(s): Takano Y, Masuda T, Iinuma H, Yamaguchi R, Sato K, Tobo T, Hirata H, Kuroda Y, Nambara S, Hayashi N, Iguchi T, Ito S, Eguchi H, Ochiya T, Yanaga K, Miyano S, Mimori K
  • Journal Title: Oncotarget Volume: 8(45) Issue: 45 Pages: 78598-78613
  • DOI: 10.18632/oncotarget.20009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] MicroRNAs as Biomarkers in Colorectal Cancer. (2017)
  • Author(s): Masuda T, Hayashi N, Kuroda Y, Ito S, Eguchi H, Mimori K
  • Journal Title: Cancers (Basel). Volume: 9(9) Issue: 9 Pages: 124-124
  • DOI: 10.3390/cancers9090124
  • Peer Reviewed / Open Access
• [Journal Article] Clinical significance of ZNF750 gene expression, a novel tumor suppressor gene, in esophageal squamous cell carcinoma. (2017)
  • Author(s): Nambara S, Masuda T, Tobo T, Kidogami S, Komatsu H, Sugimachi K, Saeki H, Oki E, Maehara Y,Mimori K
  • Journal Title: Oncol Lett Volume: 14(2) Issue: 2 Pages: 1795-1801
  • DOI: 10.3892/ol.2017.6341
  • Peer Reviewed / Open Access
• [Journal Article] Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer. (2017)
  • Author(s): Sato K, Masuda T, Hu Q, Tobo T, Kidogami S, Ogawa Y, Saito T, Nambara S, Komatsu H, Hirata H, Sakimura S, Uchi R, Hayashi N, Iguchi T, Eguchi H, Ito S, Nakagawa T,Mimori K
  • Journal Title: Anticancer Res. Volume: 37(5) Pages: 2365-2371
  • Peer Reviewed / Open Access
• [Journal Article] Up-regulation of SLC9A9 Promotes Cancer Progression and Is Involved in Poor Prognosis in Colorectal Cancer. (2017)
  • Author(s): Ueda M, Iguchi T, Masuda T, Komatsu H, Nambara S, Sakimura S, Hirata H, Uchi R, Eguchi H, Ito S, Sugimachi K, Mizushima T, Doki Y, Mori M,Mimori K
  • Journal Title: Anticancer Res. Volume: 37(5) Pages: 2255-2263
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Significance of FANCD2 Gene Expression and its Association with Tumor Progression in Hepatocellular Carcinoma (2017)
  • Author(s): Komatsu H, Masuda T, Iguchi T, Nambara S, Sato K, Hu Q, Hirata H, Ito S, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M,Mimori K
  • Journal Title: Anticancer Res. Volume: 37(3) Pages: 1083-1090
  • Peer Reviewed / Open Access
• [Journal Article] Phosphoserine Phosphatase Is a Novel Prognostic Biomarker on Chromosome 7 in Colorectal Cancer (2017)
  • Author(s): Sato K, Masuda T, Hu Q,Tobo T,Kidogami S, Ogawa Y, Saito T, Nambara S, Komatsu H, Hirata H, Sakimura S, Uchi R, Hayashi N, Iguchi T, Eguchi H, Ito S, Nakagawa T and Mimori K.
  • Journal Title: Anticancer Resarch Volume: 印刷中
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Clinical Significance of FANCD2 Gene Expression and its Association with Tumor Progression in Hepatocellular Carcinoma. (2017)
  • Author(s): Komatsu H, Masuda T, Iguchi T, Nambara S, Sato K, Hu Q, Hirata H, Ito S, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K.
  • Journal Title: Anticancer Res. Volume: 37(3) Pages: 1083-1090
  • Peer Reviewed / Open Access
• [Journal Article] Attenuated RND1 Expression Confers Malignant Phenotype and Predicts Poor Prognosis in Hepatocellular Carcinoma (2016)
  • Author(s): Komatsu H, Iguchi T, Masuda T, Hirata H, Ueda M, Kidogami S, Ogawa Y, Sato K, Hu Q, Nambara S, Saito T, Sakimura S, Uchi R, Ito S, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K.
  • Journal Title: Ann Surg Oncol. Volume: 24(3) Issue: 3 Pages: 850-859
  • DOI: 10.1245/s10434-016-5573-9
  • Peer Reviewed / Open Access
• [Journal Article] miR-146a Polymorphism (rs2910164) Predicts Colorectal Cancer Patients' Susceptibility to Liver Metastasis. (2016)
  • Author(s): Iguchi T, Nambara S, Masuda T, Komatsu H, Ueda M, Kidogami S, Ogawa Y, Hu Q, Sato K, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Maehara Y, Mimori K.
  • Journal Title: PLoS One. Volume: 11(11) Issue: 11 Pages: e0165912-e0165912
  • DOI: 10.1371/journal.pone.0165912
  • Peer Reviewed / Open Access
• [Journal Article] Somatic mutations in plasma cell-free DNA are diagnostic markers for esophageal squamous cell carcinoma recurrence (2016)
  • Author(s): Ueda M, Iguchi T, Masuda T, Nakahara Y, Hirata H, Uchi R, Niida A, Momose K, Sakimura S, Chiba K, Eguchi H, Ito S, Sugimachi K, Yamasaki M, Suzuki Y, Miyano S, Doki Y, Mori M, Mimori K
  • Journal Title: Oncotarget Volume: 7(38) Issue: 38 Pages: 62280-62291
  • DOI: 10.18632/oncotarget.11409
  • Peer Reviewed / Open Access
• [Journal Article] HOXB7 Expression is a Novel Biomarker for Long-term Prognosis After Resection of Hepatocellular Carcinoma. (2016)
  • Author(s): Komatsu H, Iguchi T, Masuda T, Ueda M, Kidogami S, Ogawa Y, Nambara S, Sato K, Hu Q, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K.
  • Journal Title: Anticancer Res. Volume: 36(6) Pages: 2767-73
  • Peer Reviewed / Open Access
• [Journal Article] Aberrant Methylation of FOXE1 Contributes to a Poor Prognosis for Patients with Colorectal Cancer. (2016)
  • Author(s): Sugimachi K, Matsumura T, Shimamura T, Hirata H, Uchi R, Ueda M, Sakimura S, Iguchi T, Eguchi H, Masuda T, Morita K, Takenaka K, Maehara Y, Mori M, Mimori K.
  • Journal Title: Ann Surg Oncol. Volume: 23(12) Issue: 12 Pages: 3948-3955
  • DOI: 10.1245/s10434-016-5289-x
  • Peer Reviewed / Open Access
• [Journal Article] Decreased Expression of Fructose-1,6-bisphosphatase Associates with Glucose Metabolism and Tumor Progression in Hepatocellular Carcinoma. (2016)
  • Author(s): Hirata H, Sugimachi K, Komatsu H, Ueda M, Masuda T, Uchi R, Sakimura S, Nambara S, Saito T, Shinden Y, Iguchi T, Eguchi H, Ito S, Terashima K, Sakamoto K, Hirakawa M, Honda H, Mimori K.
  • Journal Title: Cancer Res. Volume: 76(11) Issue: 11 Pages: 3265-76
  • DOI: 10.1158/0008-5472.can-15-2601
  • Peer Reviewed / Open Access
• [Journal Article] Increased Copy Number of the Gene Encoding SF3B4 Indicates Poor Prognosis in Hepatocellular Carcinoma. (2016)
  • Author(s): Iguchi T, Komatsu H, Masuda T, Nambara S, Kidogami S, Ogawa Y, Hu Q, Saito T, Hirata H, Sakimura S, Uchi R, Hayashi N, Ito S, Eguchi H, Sugimachi K, Maehara Y, Mimori K.
  • Journal Title: Anticancer Res. Volume: 36(5) Pages: 2139-44
  • Peer Reviewed / Open Access
• [Journal Article] Clinical and biological significance of transcription termination factor, RNA polymerase I in human liver hepatocellular carcinoma. (2016)
  • Author(s): Komatsu H, Iguchi T, Ueda M, Nambara S, Saito T, Hirata H, Sakimura S1, Takano Y1, Uchi R1, Shinden Y, Eguchi H, Masuda T, Sugimachi K, Eguchi H, Doki Y, Mori M, Mimori K.
  • Journal Title: Oncol Rep Volume: 35 Issue: 4 Pages: 2073-80
  • DOI: 10.3892/or.2016.4593
  • Peer Reviewed / Open Access
• [Presentation] 次世代シークエンサーを用いた陥凹型大腸癌の分子遺伝学的解析 (2019)
  • Author(s): 増田隆明
  • Organizer: 第15回日本消化管学会総会学術集会
• [Presentation] 大腸癌の進展におけるmicroRNA-203（miR-203）の局在依存的な相反する機能 (2018)
  • Author(s): 増田隆明、高野裕樹、飯沼久恵、倉光正太郎、藤井昌志、北川彰洋、清水大、野田美和、吉川幸宏、胡慶江、鶴田祐介、黒田陽介、江口英利、矢永勝彦、三森功士
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 大腸癌におけるAGAP3の分子生物学的意義の検討 (2018)
  • Author(s): 清水大、佐藤晋彰、伊藤修平、増田隆明、北川彰洋、倉光正太郎、添田祐治、藤井昌志、神山勇太、野田美和、吉川幸宏、脇山浩明、胡慶江、齋藤衆子、鶴田祐介、黒田陽介、江口英利、小寺泰弘、三森功士
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 大腸がんにおける術源術後の経時的血清中microRNAの臨床的有用性について (2018)
  • Author(s): 吉川幸宏、福永光子、増田隆明、伊藤修平、清水大、倉光正太郎、藤井昌志、北川彰洋、野田美和、胡慶江、鶴田祐介、黒田陽介、江口英利、山田一隆、土岐祐一郎、森正樹、三森功士
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 7番染色体短腕（7p）に存在する大腸癌の新規ドライバー遺伝子DDX56の同定 (2018)
  • Author(s): 鶴田祐介、神山勇太、増田隆明、小川悠史、佐藤晋彰、胡慶江、野田美和、吉川幸宏、北川彰洋、藤井昌志、倉光正太郎、清水大、伊藤修平、江口英利、黒田陽介、三森功士
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 陥凹型早期大腸癌の遺伝子学的特徴 (2018)
  • Author(s): 江口英利、北川彰洋、倉光正太郎、清水大、藤井昌志、野田美和、吉川幸宏、胡慶江、鶴田祐介、黒田陽介、増田隆明、伊藤修平、三森功士
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] Circulating exosomal miR-203 is associated with metastasis via inducing tumor-associated macrophages in colorectal cancer (2018)
  • Author(s): D Shimizu, T Masuda, Y Takano, H Iinuma, R Yamaguchi, K Sato, T Tobo, H Hirata, Y Kuroda, S Nambara, N Hayashi, T Iguchi, S Ito, H Eguchi, T Ochiya, K Yanaga, S Miyano, K Mimori.
  • Organizer: AACR Annual Meeting 2018
  • Int'l Joint Research
• [Presentation] 陥凹型早期大腸癌の分子生物学的特徴 (2018)
  • Author(s): 神山勇太、増田隆明、小川悠史、工藤孝毅、江口英利、工藤進英、三森功士
  • Organizer: 第27回日本癌病態治療研究会
• [Presentation] 大腸がんにおいて転移を決める条件について (2018)
  • Author(s): 北川彰洋、黒田陽介、鶴田祐介、大津甫、江口英利、増田隆明、三森功士
  • Organizer: 第230回大分県外科医会
• [Presentation] 陥凹型早期大腸癌における網羅的遺伝子解析の検討 (2018)
  • Author(s): 江口英利、清水大、倉光正太郎、吉川幸宏、胡慶江、鶴田祐介、黒田陽介、増田隆明、伊藤修平、三森功士
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] 7番染色体短腕（7p）に存在する大腸癌の新規ドライバー遺伝子DEAD Box Helicase56(DDX56)の同定 (2018)
  • Author(s): 増田隆明、倉光正太郎、藤井昌志、北川彰洋、胡慶江、鶴田祐介、黒田陽介、伊藤修平、江口英利、三森功士
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] 大腸がんにおける経時的血清中microRNAのコンビネーションの臨床的有用性 (2018)
  • Author(s): 吉川幸宏、福永光子、伊藤修平、増田隆明、江口英利、山田一隆、土岐祐一郎、森正樹、三森功士
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] 新規癌遺伝子oxysterol binding protein like 3(OSBPL3)の大腸癌における臨床的意義 (2018)
  • Author(s): 胡慶江、増田隆明、倉光正太郎、鶴田祐介、黒田陽介、伊藤修平、江口英利、沖英次、前原喜彦、三森功士
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] 大腸がんにおける経時的血清中microRNAのコンビネーションの臨床的有用性 (2018)
  • Author(s): 吉川幸宏、増田隆明、清水大、大津甫、黒田陽介、江口英利、山田一隆、土岐祐一郎、森正樹、三森功士
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] elF5 Mimic Protein 1(5MP1)はMYCの翻訳開始点をリプログラムし大腸癌の悪性化を促進する (2018)
  • Author(s): 佐藤晋彰、増田隆明、胡慶江、齋藤衆子、脇山浩明、吉川幸宏、神山勇太、野田美和、黒田陽介、江口英利、中川尚志、三森功士
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 大腸癌におけるAGAP3の分子生物学的意義の検討 (2018)
  • Author(s): 清水大、齋藤衆子、佐藤晋彰、増田隆明、大津甫、黒田陽介、江口英利、神田光郎、小寺泰弘、三森功士
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 大腸癌におけるoxysterol binding protein like 3(OSBPL3)の臨床的意義 (2018)
  • Author(s): 江口英利、胡慶江、増田隆明、清水大、藤井昌志、野田美和、神山勇太、吉川幸宏、脇山浩明、佐藤晋彰、鶴田祐介、黒田陽介、三森功士
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 大腸癌において7番染色体短腕のDEAD-Box Helicase56の増幅が癌化に影響するスプライシング異常を誘導する (2018)
  • Author(s): 黒田陽介、神山勇太、増田隆明、野田美和、吉川幸宏、佐藤晋彰、清水大、鶴田祐介、大津甫、江口英利、三森功士
  • Organizer: 第77回日本癌学会学術総会
  • Int'l Joint Research
• [Presentation] 大腸癌における新たながん遺伝子5MP1はMYCの翻訳リプログラミングを介して細胞増殖を促進する (2018)
  • Author(s): 佐藤晋彰、増田隆明、大津甫、鶴田祐介、江口英利、黒田陽介、三森功士
  • Organizer: 第29回日本消化器癌発生学会
• [Presentation] Identification of novel candidate driver genes of colorectal cancer on chromosome 7p. (2017)
  • Author(s): Kouyama Y, Ogawa Y, Masuda T, Yoshikawa Y, Noda M, Wakiyama H, Sato K, Nambara S, Hu Q, Kidogami S, Saito T, Sakimura S, Hayashi N, Kuroda Y, Ito S, Eguchi H, Mimori K.
  • Organizer: AACR Annual Meeting
  • Place of Presentation: ワシントンD.C.
  • Year and Date: 2017-04-01
  • Int'l Joint Research
• [Presentation] 大腸がんゲノムデータに基づいた多様性克服のための戦略 (2017)
  • Author(s): 増田隆明、野田美和、吉川幸宏、木戸上真也、胡慶江、南原翔、林直樹、黒田陽介、伊藤修平、江口英利、三森功士
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 大腸がんにおける血漿中エクソソーム内miR-203発現の臨床的意義 (2017)
  • Author(s): 増田隆明、高野裕樹、飯沼久恵、胡慶江、南原翔、林直樹、黒田陽介、伊藤修平、江口英利、三森功士
  • Organizer: 第72回日本消化器外科学会
• [Presentation] 大腸がんにおいて血中エクソソーム内miR-203発現は転移と相関する (2017)
  • Author(s): 増田隆明、高野裕樹、飯沼久恵、山口類、佐藤晋彰、林直樹、黒田陽介、伊藤修平、東保太郎、宮野悟、矢永勝彦、三森功士
  • Organizer: 第76回日本癌学会
• [Presentation] LoxL1は胃癌腹膜播種の新規バイオマーカーである (2016)
  • Author(s): 増田隆明、胡慶江、木戸上真也、佐藤晋彰、齋藤衆子、南原翔、小松久晃、﨑村正太郎、平田秀成、林直樹、黒田陽介、伊藤修平、三森功士
  • Organizer: 第75回日本癌学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06
• [Presentation] PSPHは7番染色体上に存在する大腸癌の新規ドライバー候補遺伝子である (2016)
  • Author(s): 佐藤晋彰、胡慶江、木戸上真也、齋藤衆子、南原翔、小松久晃、平田秀成、﨑村正太郎、黒田陽介、伊藤修平、江口英利、増田隆明、三森功士
  • Organizer: 第75回日本癌学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2016-10-06
• [Presentation] 数理生物統合解析による大腸癌のドライバー遺伝子BZW2の同定とその臨床学的意義. (2016)
  • Author(s): 増田隆明、胡慶江、木戸上真也、南原翔、小松久晃、林直樹、井口友宏、伊藤修平、江口英利、三森功士
  • Organizer: 第71回日本消化器外科学会
  • Place of Presentation: 徳島
  • Year and Date: 2016-07-20