Analysis of the profile in DNA methylation alterations to predict susceptibility to cancer development

• Project/Area Number: 16K10548
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Digestive surgery
• Research Institution: Jichi Medical University
• Principal Investigator: Rikiyama Toshiki 自治医科大学, 医学部, 教授 (80343060)
• Co-Investigator(Kenkyū-buntansha): 鈴木 浩一 自治医科大学, 医学部, 准教授 (70332369)
• Project Period (FY): 2016-04-01 – 2020-03-31
• Project Status: Completed (Fiscal Year 2019)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2018: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2016: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 癌易罹患性 / DNAメチル化プロファイル / 遺伝子修飾異常 / 遺伝子異常 / 非癌部組織 / DNAメチル化マイクロアレイ / MS-AFLP microarray / DNAメチル化異常 / MS-AFLP / 発癌リスク / 発癌プロファイル / DNA メチル化異常 / メチル化プロファイル

Outline of Final Research Achievements

The aim of this study is to predict susceptibility to cancer development on the basis of the epigenetic profile observed in non-cancerous mucosa. Epigenetic alterations are commonly observed not only in cancer tissues but also in non-cancerous tissues, whereas genetic alterations are found in isolated cases and in only in a minor fraction of normal tissue cells. Thus, the epigenetic profiles is considered to be a hallmark of cancer development initiation. PCR-based DNA fingerprinting method called methylation-sensitive amplified fragment length polymorphism (MS-AFLP) analysis enables simultaneous genome-wide detection of DNA hypermethylation and hypomethylation in tumor tissue. The array-based platform, which we adapted from former platform, interrogates over 9500 independent loci, corresponding to the NotI sites mapped throughout the human genome. We identified cancer related genes involved in WNT signaling, AXON guidance and Homeobox genes.

Academic Significance and Societal Importance of the Research Achievements

近年、網羅的ゲノム検索により多くの遺伝子が同定されました。大腸癌276症例のwhole genome studyによると腫瘍抑制遺伝子APC が関与するWNTシグナル伝達系において、その経路のどこかに遺伝子異常がある大腸癌の頻度は92-97%と非常に高い数値を示しました。すなわち、APCに異常を認めなくても、APCのシグナル伝達に関わる遺伝子の異常を多くの大腸癌が有していたという事です。この結果より、一連のシグナル伝達系に関わる遺伝子変化を包括的に検索し、解析する事の重要性が示されました。しかしながら、このような網羅的ゲノ ム検索を正常組織で行い、癌組織の変化と関連づけた報告はありません。

Research Products

• [Journal Article] Efficacy of Neoadjuvant Chemotherapy with Capecitabine plus Oxaliplatin in the Treatment of Locally Advanced Sigmoid Colon Cancer Invading the Urinary Bladder: A Report of Three Cases (2019)
  • Author(s): Takenami Tsutomu、Tsujinaka Shingo、Takahashi Jun、Tamaki Sawako、Maemoto Ryo、Fukuda Rintaro、Ishikawa Hideki、Kakizawa Nao、Hasegawa Fumi、Kikugawa Rina、Miyakura Yasuyuki、Suzuki Koichi、Tanaka Akira、Rikiyama Toshiki
  • Journal Title: Case Reports in Surgery Volume: 2019 Pages: 1-7
  • DOI: 10.1155/2019/8129358
  • Peer Reviewed / Open Access
• [Journal Article] Longitudinal monitoring of KRAS-mutated circulating tumor DNA enables the prediction of prognosis and therapeutic responses in patients with pancreatic cancer. (2019)
  • Author(s): Fumiaki Watanabe, Koichi Suzuki*, Sawako Tamaki, Iku Abe, Yuhei Endo, Yuji Takayama, Hideki Ishikawa, Nao Kakizawa, Masaaki Saito, Kazushige Futsuhara, Hiroshi Noda, Fumio Konishi, Toshiki Rikiyama
  • Journal Title: PLOS ONE Volume: 14 Issue: 12 Pages: e0227366-e0227366
  • DOI: 10.1371/journal.pone.0227366
  • Peer Reviewed / Open Access
• [Journal Article] Temporary loss of consciousness during cetuximab treatment of a patient with metastatic colon cancer: a case report. (2019)
  • Author(s): Taro Fukui,Koichi Suzuki,Sawako Tamaki,Iku Abe,Yuhei Endo,Hideki Ishikawa,Nao Kakizawa,Fumiaki Watanabe,Masaaki Saito,Shingo Tsujinaka,Kazushige Futsuhara,Yasuyuki Miyakura,Hiroshi Noda,Toshiki Rikiyama
  • Journal Title: Surgical case reports Volume: 5 Issue: 1 Pages: 145-145
  • DOI: 10.1186/s40792-019-0707-5
  • Peer Reviewed / Open Access
• [Journal Article] High relative levels of satellite alpha transcripts predict increased risk of bilateral breast cancer and multiple primary cancer in patients with breast cancer and lacking BRCA_related clinical features. (2019)
  • Author(s): Nao Kakizawa,Koichi Suzuki,Iku Abe,Yuhei Endo,Sawako Tamaki,Hideki Ishikawa,Fumiaki Watanabe,Kosuke Ichida,Masaaki Saito,Kazusige Futsuhara,Fumio Konishi,Toshiki Rikiyama
  • Journal Title: Oncology reports Volume: 42 Pages: 857-865
  • DOI: 10.3892/or.2019.7182
  • Peer Reviewed
• [Journal Article] Multiple primary malignancies of six organs in a Japanese male patient: A case report. (2019)
  • Author(s): Yuta Muto,Koichi Suzuki,Takaharu Kato,Kosuke Ichida,Yuji Takayama,Taro Fukui,Nao Kakizawa,Fumiaki Watanabe,Yuji Kaneda,Hiroshi Noda,Toshiki Rikiyama
  • Journal Title: Molecular and clinical oncology Volume: 10 Pages: 511-515
  • DOI: 10.3892/mco.2019.1819
  • Peer Reviewed / Open Access
• [Journal Article] Extracellular Spermine Activates DNA Methyltransferase 3A and 3B (2019)
  • Author(s): Fukui Taro、Soda Kuniyasu、Takao Koichi、Rikiyama Toshiki
  • Journal Title: International Journal of Molecular Sciences Volume: 20 Issue: 5 Pages: 1254-1254
  • DOI: 10.3390/ijms20051254
  • Peer Reviewed / Open Access
• [Journal Article] A Retrospective Analysis of Preoperative Evaluation and Surgical Resection for Metastatic Tumors of the Pancreas. (2019)
  • Author(s): Yuhei Endo, Hiroshi Noda, Fumiaki Watanabe, Takaharu Kato, Nao Kakizawa, Kosuke Ichida, Naoya Kasahara, Toshiki Rikiyama
  • Journal Title: Indian J Surg Oncol Volume: 10 Issue: 2 Pages: 251-257
  • DOI: 10.1007/s13193-019-00905-w
  • Peer Reviewed
• [Journal Article] Monitoring circulating tumor DNA revealed dynamic changes in KRAS status in patients with metastatic colorectal (2018)
  • Author(s): Yuji Takayama, Koichi Suzuki, Yuta Muto, Kosuke Ichida, Taro Fukui, Nao Kakizawa, Hideki Ishikawa, Fumiaki Watanabe, Fumi Hasegawa, Masaaki Saito, Shingo Tsujinaka, Kazushige Futsuhara, Yasuyuki Miyakura, Hiroshi Noda, Fumio Konishi, Toshiki Rikiyama
  • Journal Title: Oncotarget Volume: 9 Issue: 36 Pages: 24398-24413
  • DOI: 10.18632/oncotarget.25309
  • Peer Reviewed / Open Access
• [Journal Article] Methylation-Sensitive Amplification Length Polymorphism (MS-AFLP) Microarrays for Epigenetic Analysis of Human Genomes (2018)
  • Author(s): Alonso Sergio、Suzuki Koichi、Yamamoto Fumiichiro、Perucho Manuel
  • Journal Title: Methods in molecular biology Volume: 1766 Pages: 137-156
  • DOI: 10.1007/978-1-4939-7768-0_8
  • ISBN: 9781493977673, 9781493977680
  • Peer Reviewed
• [Journal Article] Overexpression of satellite alpha transcripts leads to chromosomal instability via segregation errors at specific chromosomes. (2018)
  • Author(s): Ichida K, Suzuki K, Fukui T, Takayama Y, Kakizawa N, Watanabe F, Ishikawa H, Muto Y, Kato T, Saito M, Futsuhara K, Miyakura Y, Noda H, Ohmori T, Konishi F, Rikiyama T.
  • Journal Title: Int J Oncol. Volume: - Pages: 1685-1693
  • DOI: 10.3892/ijo.2018.4321
  • Peer Reviewed / Open Access
• [Journal Article] Significance of the Difference in the Size of Liver Tumors in the Management of Patients with Colorectal Liver Metastases (2017)
  • Author(s): Ichida Kosuke、Suzuki Koichi、Fukui Taro、Takayama Yuji、Kakizawa Nao、Muto Yuta、Kato Takaharu、Hasegawa Fumi、Watanabe Fumiaki、Kaneda Yuji、Kikugawa Rina、Saito Masaaki、Tsujinaka Shingo、Futsuhara Kazushige、Miyakura Yasuyuki、Noda Hiroshi、Kiyozaki Hirokazu、Rikiyama Toshiki
  • Journal Title: Journal of Molecular and Genetic Medicine Volume: 11 Issue: 1
  • DOI: 10.4172/1747-0862.1000254
  • Peer Reviewed / Open Access
• [Journal Article] Morphological response contributes to patient selection for rescue liver resection in chemotherapy patients with initially un-resectable colorectal liver metastasis (2017)
  • Author(s): Suzuki Koichi、Muto Yuta、Ichida Kosuke、Fukui Taro、Takayama Yuji、Kakizawa Nao、Kato Takaharu、Hasegawa Fumi、Watanabe Fumiaki、Kaneda Yuji、Kikukawa Rina、Saito Masaaki、Tsujinaka Shingo、Futsuhara Kazushige、Takata Osamu、Noda Hiroshi、Miyakura Yasuyuki、Kiyozaki Hirokazu、Konishi Fumio、Rikiyama Toshiki
  • Journal Title: Oncology Letters Volume: 14 Issue: 2 Pages: 1491-1499
  • DOI: 10.3892/ol.2017.6338
  • Peer Reviewed / Open Access
• [Journal Article] Sequential administration of XELOX and XELIRI is effective, feasible and well tolerated by patients with metastatic colorectal cancer (2017)
  • Author(s): Fukui Taro、Suzuki Koichi、Ichida Kosuke、Takayama Yuji、Kakizawa Nao、Muto Yuta、Hasegawa Fumi、Watanabe Fumiaki、Kikugawa Rina、Saito Masaaki、Tsujinaka Shingo、Miyakura Yasuyuki、Rikiyama Toshiki
  • Journal Title: Oncology Letters Volume: 13 Issue: 6 Pages: 4947-4952
  • DOI: 10.3892/ol.2017.6100
  • Peer Reviewed / Open Access
• [Journal Article] A High Abdominal Aortic Calcification Score on CT is a Risk Factor for Postoperative Pancreatic Fistula in Elderly Patients Undergoing Pancreaticoduodenectomy (2017)
  • Author(s): Kakizawa Nao、Noda Hiroshi、Watanabe Fumiaki、Ichida Kosuke、Suzuki Koichi、Rikiyama Toshiki
  • Journal Title: World Journal of Surgery Volume: 42 Issue: 4 Pages: 1129-1137
  • DOI: 10.1007/s00268-017-4240-z
  • Peer Reviewed
• [Journal Article] En bloc pancreaticoduodenectomy and right hemicolectomy for locally advanced right-sided colon cancer (2017)
  • Author(s): Kaneda Yuji、Noda Hiroshi、Endo Yuhei、Kakizawa Nao、Ichida Kosuke、Watanabe Fumiaki、Kato Takaharu、Miyakura Yasuyuki、Suzuki Koichi、Rikiyama Toshiki
  • Journal Title: World Journal of Gastrointestinal Oncology Volume: 9 Issue: 9 Pages: 372-372
  • DOI: 10.4251/wjgo.v9.i9.372
  • Peer Reviewed / Open Access
• [Journal Article] Pitfalls of KRAS Testing for Treating Patients with Metastatic Colorectal Cancer (2016)
  • Author(s): Suzuki K, Rikiyama T
  • Journal Title: J Clin Epigenet Volume: 2-2 Issue: 2 Pages: 18-27
  • DOI: 10.21767/2472-1158.100018
  • Peer Reviewed
• [Journal Article] Clinical characteristics of synchronous colorectal cancers in Japan (2016)
  • Author(s): Kato T, Alonso S, Muto Y, Noda H, Miyakura Y, Suzuki K, Tsujinaka S, Saito M, Perucho M, Rikiyama T
  • Journal Title: World journal of surgical oncology Volume: 14 Issue: 1 Pages: 272-272
  • DOI: 10.1186/s12957-016-1027-x
  • Peer Reviewed / Open Access
• [Journal Article] Heterogeneous expression of zinc-finger E-box-binding homeobox 1 plays a pivotal role in metastasis via regulation of miR-200c in epithelial-mesenchymal transition (2016)
  • Author(s): Muto Y, Suzuki K, Kato T, Tsujinaka S, Ichida K, Takayama Y, Fukui T, Kakizawa N, Watanabe F, Saito M, Futsuhara K, Noda H, Miyakura Y, Konishi F and Rikiyama
  • Journal Title: Int J Oncol. Volume: 49(3) Issue: 3 Pages: 1057-1067
  • DOI: 10.3892/ijo.2016.3583
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] Significance of monitoring plasma vascular endothelial growth factor signals during treatment of colorectal cancer patients. (2019)
  • Author(s): Nao Kakizawa, Koichi Suzuki, Hideki Ishikawa, Fumiaki Watanabe, Fumi Hasegawa, Rina Kikugawa, Shingo Tsujinaka, Kazushige Futsuhara, Yasuyuki Miyakura, Toshiki Rikiyama
  • Organizer: Gastrointestinal Cancers Symposium
  • Int'l Joint Research
• [Presentation] Clinical significance of monitoring KRAS in tissue and plasma of pancreatic cancer patients. (2019)
  • Author(s): Fumiaki Watanabe, Koichi Suzuki, Yuhei Endo, Hideki Ishikawa, Nao Kakizawa, Hiroshi Noda, Toshiki Rikiyama
  • Organizer: Gastrointestinal Cancers Symposium
  • Int'l Joint Research
• [Presentation] 上行結腸癌術後異時性孤発性胃壁転移の1例 (2019)
  • Author(s): 兼光梨奈、笠原尚哉、相澤栄俊、遠藤裕平、加藤高晴、野田弘志、鈴木浩一、山田茂樹、力山敏樹
  • Organizer: 日本消化器病学会関東支部第54回例会
• [Presentation] 多臓器浸潤局所進行右側結腸癌に対する右半結腸切除+膵頭十二指腸切除の適応と治療成績の検討 (2019)
  • Author(s): 野田弘志、渡部文昭、加藤高晴、笠原尚哉、遠藤裕平、相澤栄俊、辻仲眞康、宮倉安幸、鈴木浩一、力山敏樹
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 膵頭十二指腸切除術における乳糜の発生状況と周術期危険因子の解析 (2019)
  • Author(s): 福井太郎、野田弘志、相澤栄俊、遠藤裕平、渡部文昭、笠原尚哉、加藤高晴、齊藤正昭、辻仲眞康、宮倉安幸、清崎浩一、鈴木浩一、力山敏樹
  • Organizer: 第119回日本外科学会定期学術集会
• [Presentation] 膵癌患者における血中KRASクローンモニタリングの有用性 (2019)
  • Author(s): 渡部文昭、鈴木浩一、相澤栄俊、遠藤裕平、笠原尚哉、加藤高晴、野田弘志、力山敏樹
  • Organizer: 第36回日本胆膵病態・生理研究会
• [Presentation] 反復配列におけるエピジェネティック異常をバイオマーカーとしたfield defectの評価 (2019)
  • Author(s): 齊藤正昭、鈴木浩一、市田晃佑、阿部 郁、遠藤裕平、田巻佐和子、石川英樹、柿澤奈緒、渡部文昭、蓬原一茂、力山敏樹
  • Organizer: 第28回日本癌病態治療研究
• [Presentation] ctDNA Gene Panelによる標的分子の同定とDigital PCRによる血液モニタリング (2019)
  • Author(s): 鈴木浩一、石川英樹、柿澤奈緒、渡部文昭、阿部 郁、遠藤裕平、田巻佐和子、齊藤正昭、辻仲眞康、蓬原一茂、宮倉安幸、野田弘志、清崎浩一、力山敏樹
  • Organizer: 第28回日本癌病態治療研究会
• [Presentation] 膵癌患者における血中KRASクローンモニタリングの有用性 (2019)
  • Author(s): 渡部文昭、鈴木浩一、相澤栄俊、遠藤裕平、笠原尚哉、加藤高晴、野田弘志、力山敏樹
  • Organizer: 第28回日本癌病態治療研究会
• [Presentation] 膵癌におけるKRAS変異のheterogeneityの検討 (2019)
  • Author(s): 渡部文昭、鈴木浩一、相澤栄俊、遠藤裕平、笠原尚哉、加藤高晴、野田弘志、力山敏樹
  • Organizer: 第50回膵臓学会大会
• [Presentation] 当院における下部進行直腸癌に対する術前治療の変遷と治療成績の比較 (2019)
  • Author(s): 長谷川芙美、宮倉安幸、辻仲眞康、菊川利奈、石川英樹、田巻佐和子、鈴木浩一、清崎浩一、野田弘志、力山敏樹
  • Organizer: 第74回日本消化器外科学会
• [Presentation] 直腸癌術後の一時的回腸ストーマ造設状態における補助化学療法の忍容性に関する検討 (2019)
  • Author(s): 高橋 洵、辻仲眞康、田巻佐和子、竹浪 努、福田臨太郎、長谷川芙美、菊川利奈、鈴木浩一、宮倉安幸、力山敏樹
  • Organizer: 第74回日本消化器外科学会
• [Presentation] 当院における胃癌に対するニボルマブの使用経験 (2019)
  • Author(s): 武藤雄太、齊藤正昭、町田枝里華、前本 遼、石岡大輔、鈴木浩一、清崎浩一、力山敏樹
  • Organizer: 第74回日本消化器外科学会
• [Presentation] 通常型膵管癌切除後長期生存例の検討 (2019)
  • Author(s): 笠原尚哉、野田弘志、相澤栄俊、遠藤裕平、渡部文昭、加藤高晴、鈴木浩一、力山敏樹
  • Organizer: 第74回日本消化器外科学会
• [Presentation] 胆管悪性腫瘍に対する肝切除術後に膵頭十二指腸切除術を行った2症例 (2019)
  • Author(s): 福井太郎、野田弘志、相澤栄俊、遠藤裕平、渡部文昭、笠原尚哉、加藤高晴、宮倉安幸、鈴木浩一、力山敏樹
  • Organizer: 第74回日本消化器外科学会
• [Presentation] 膵癌患者における血中KRASモニタリングの有用性 (2019)
  • Author(s): 渡部文昭、鈴木浩一、相澤栄俊、遠藤裕平、笠原尚哉、加藤高晴、野田弘志、力山敏樹
  • Organizer: 第17回日本消化器外科学会大会
• [Presentation] リキッドバイオプシーによるがん診療のパラダイムシフト～大腸癌の後方ライン治療の有効性 (2019)
  • Author(s): 鈴木浩一
  • Organizer: 第74回日本大腸肛門病学会
  • Invited
• [Presentation] Clinical significance of monitoring KRSA in tissue and serum of pancreatic cancer patients (2018)
  • Author(s): Watanabe F, Suzuki K, Ishikawa H, Endo Y, Ichida K, Takayama Y, Fukui T, Kakizawa N, Kasahara N, Kato T, Noda H, Rikiyama T
  • Organizer: Gastrointestinal Cancers Symposium
  • Int'l Joint Research
• [Presentation] Dynamics and characteristics of KRAS mutated circulating tumor DNA in patients with metastatic colorectal cancer during various treatments (2018)
  • Author(s): Takayama Y, Suzuki K, Ichida K, Fukui T, Kakizawa N, Watanabe F, Kikukawa R, Hasegawa F, Tsujinaka S, Miyakura Y, Konishi F, Rikiyama T
  • Organizer: Gastrointestinal Cancers Symposium
  • Int'l Joint Research
• [Presentation] Liquid biopsy leads to a paradigm shift in colorectal cancer treatments (2018)
  • Author(s): Suzuki K, Takayama Y, Kakizawa N, Ichida K, Fukui T, Watanabe F, Ishikawa H, Saito M, Miyakura Y, Rikiyama T
  • Organizer: 第73回日本消化器外科学会総会
• [Presentation] リキッドバイオプシーによる大腸癌診療のパラダイムシフト (2018)
  • Author(s): 鈴木浩一
  • Organizer: Saitama CRC Seminar
  • Invited
• [Presentation] 膵癌に対する組織と血中のKRASモニタリングの有用性 (2018)
  • Author(s): 渡部文昭、鈴木浩一、遠藤裕平、笠原尚哉、加藤高晴、齊藤正昭、辻仲眞康、宮倉安幸、野田弘志、清崎浩一、力山敏樹
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] 膵癌に対する術前治療に組織と血中のKRASモニタリングは有用か (2018)
  • Author(s): 渡部文昭、鈴木浩一、力山敏樹
  • Organizer: 第104回日本消化器病学会総会学術集会
• [Presentation] Clinical significance of monitoring KRAS in tissue and plasma of pancreatic cancer patients (2018)
  • Author(s): Watanabe F
  • Organizer: 第17回自治医科大学シンポジウム
• [Presentation] Significance of monitoring vascular endothelial growth factor signals in blood during treatment of colorectal cancer patients (2018)
  • Author(s): Kakizawa N, Suzuki K, Ishikawa H, Watanabe F, Kikugawa R, Tsujinaka S, Miyakura Y, Rikiyama T
  • Organizer: 第17回自治医科大学シンポジウム
• [Presentation] Significance of monitoring VEGF signals in blood during treatment of colorectal cancer patient (2018)
  • Author(s): 柿澤奈緒、鈴木浩一、石川英樹、渡部文昭、辻仲眞康、宮倉安幸、力山敏樹
  • Organizer: 第77回日本癌学会学術総会
• [Presentation] リキッドバイオプシーによるがん診療のパラダイムシフト (2018)
  • Author(s): 鈴木浩一
  • Organizer: 第27回日本がん転移学会
  • Invited
• [Presentation] DNA脱メチル化異常をバイオマーカーとする胃切除範囲への臨床応用 (2018)
  • Author(s): 齊藤正昭、清崎浩一、小櫃 保、伊瀬谷和輝、石岡大輔、辻仲眞康、宮倉安幸、鈴木浩一、野田弘志、力山敏樹
  • Organizer: 第118回日本外科学会定期学術集会
• [Presentation] The clinical significance of KRAS monitoring in tumor tissues and blood of patients with pancreatic tumor (2017)
  • Author(s): Watanabe F, Suzuki K, Ichida K, Takayama Y, Fukui T, Kakizawa N, Rikiyama T
  • Organizer: Gastrointestinal Cancers Symposium
  • Int'l Joint Research
• [Presentation] Appearance of KRAS mutated circulating tumor DNA during various treatments for metastatic colorectal cancer patients (2017)
  • Author(s): Takayama Y, Suzuki K, Ichida K, Fukui T, Kakizawa N, Watanabe F, Hasegawa F, Tsujinaka S, Miyakura Y, Noda H, Rikiyama T
  • Organizer: Exosomes and Liquid Biopsies ASIA
  • Int'l Joint Research
• [Presentation] Liquid Biopsyによるがん診療のパラダイムシフト (2017)
  • Author(s): 鈴木浩一、高山裕司、渡部文昭、市田晃佑、福井太郎、柿澤奈緒、齊藤正昭、辻仲眞康、蓬原一茂、宮倉安幸、力山敏樹
  • Organizer: 第26回日本癌病態治療研究会
• [Presentation] セントロメア領域の脱メチル化は、染色体不安定性を誘導する (2017)
  • Author(s): 齊藤正昭、鈴木浩一、市田晃佑、高橋洵、石岡大輔、小櫃保、清崎浩一、力山敏樹
  • Organizer: 第89回日本胃癌学会総会
• [Presentation] 乳癌両側発生、多臓重複器発生に関わる染色体分配の異常とSatellite alpha transcripts (2017)
  • Author(s): 蓬原一茂、柿澤奈緒、鈴木浩一、齊藤正昭、市田晃佑、佐藤あい、吉沢あゆは、野口友里、尾本きよか、力山敏樹
  • Organizer: 第25回乳癌学会学術集会
• [Presentation] 膵腫瘍性病変における組織と血中のKrasモニタリングの臨床的意義 (2017)
  • Author(s): 渡部文昭、鈴木浩一、遠藤裕平、市田晃佑、福井太郎、柿澤奈緒、兼田裕司、野田弘志、力山敏樹
  • Organizer: 第117回日本外科学会定期学術集会
• [Presentation] 乳癌においてSatellite alpha transcript過剰発現が惹起する染色体不安定性 (2017)
  • Author(s): 市田晃佑、鈴木浩一、福井太郎、高山裕司、柿澤奈緒、渡部文昭、石川英樹、齊藤正昭、武藤雄太、加藤高晴、蓬原一茂、力山敏樹
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Specific chromosomes were impaired by overexpression of Satellite alpha transcript in breast cancer patients (2017)
  • Author(s): 市田晃佑、鈴木浩一、高山裕司、福井太郎、渡部文昭、柿澤奈緒、石川英樹、加藤高晴、齊藤正昭、力山敏樹
  • Organizer: 第16回自治医科大学シンポジウム
• [Presentation] 治療中の転移性大腸癌患者におけるKRAS変異型血中遊離DNA出現パターンの同定 (2017)
  • Author(s): 高山裕司、鈴木浩一、市田晃佑、福井太郎、渡部文昭、菊川利奈、長谷川芙美、辻仲眞康、宮倉安幸、野田弘志、小西文雄、力山敏樹
  • Organizer: 第76回日本癌学会学術総会
• [Presentation] Appearance and characteristic of KRAS mutated circulating tumor DNA in patients with metastatic colorectal cancer during various treatments (2017)
  • Author(s): 高山裕司
  • Organizer: 第16回自治医科大学シンポジウム
• [Book] 癌免疫カンファレンスルーム (2019)
  • Author(s): 鈴木 浩一、力山 敏樹
  • Total Pages: 4
  • Publisher: へるす出版