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Deciphering the specific sugar code of the gastro-intestinal cancer

Research Project

Project/Area Number 16K10563
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionUniversity of Tsukuba

Principal Investigator

hashimoto shinji  筑波大学, 医学医療系, 研究員 (60624666)

Co-Investigator(Kenkyū-buntansha) 小田 竜也  筑波大学, 医学医療系, 教授 (20282353)
Research Collaborator Tateno Hiroaki  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords膵癌マーカー / 糖鎖 / レクチン / 早期診断 / 消化器癌 / 腫瘍マーカー / 組織アレイ / 膵癌 / 癌 / レクチンマイクロアレイ
Outline of Final Research Achievements

Lectins are proteins that specifically recognize and bind glycans, helpful indication of glycosylation patterns. We performed histochemical staining by 20 types of lectins for cancer and normal tissues. Method: we used a panel of 20 types of lectins histochemical staining for various cancer and normal tissues. The staining patterns were firstly classified according to the ratio between cancer cells and stromal cells. The staining in cancer cell were compared with that of non cancerous pancreatic ductal epithelial cells. Result: Among 20 lectins, lectin Z showed cancer cell staining higher than normal tissue especially in pancreatic cancer. Pancreatic cancer cell 71% were positive for lectin Z, but normal pancreatic duct cells 4% were positive in patients of pancreatic cancer. Conclusion: Our result indicated that specific affinity of lectin Z would be a potential candidate of novel tumor in pancreatic cancer.

Academic Significance and Societal Importance of the Research Achievements

本研究はレクチン工学の技術を応用し、様々な標識レクチンを用いて直接染色することにより、消化器癌における網羅的な糖鎖変化を解析した研究である。我々の解析により、特に腺癌系で正常部と比較し、優位に癌部において反応性が上昇するレクチンが複数同定された。これらは、今後更に解析が進むと糖鎖プローブとして用いることで、これまで用いられてきた腫瘍マーカーに代わって有用な血清マーカーとなったり、特に膵臓癌などでは予後不良患者の割出にも有効となる可能性がある。また現在開発中である、レクチン薬剤複合体による癌治療の新たなターゲットとなる可能性もあり、今後、創薬や診断薬へ繋がることが期待される研究である。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (8 results)

All 2017 2016

All Journal Article (4 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (4 results)

  • [Journal Article] Platelet x CRP Multiplier Value as an Indicator of Poor Prognosis in Patients With Resectable Pancreatic Cancer.2017

    • Author(s)
      Miyamoto R, Oda T, Hashimoto S, Kurokawa T, Kohno K, Akashi Y, et al
    • Journal Title

      Pancreas

      Volume: 46(1) Pages: 35-41

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pancreatic neuroendocrine tumor and solid-pseudopapillary neoplasm: Key immunohistochemical profiles for differential diagnosis2016

    • Author(s)
      Ohara Y, Oda T, Hashimoto S, Akashi Y, Miyamoto R, Enomoto T, et al.
    • Journal Title

      World J Gastroenterol

      Volume: 22(38) Pages: 8596-8604

    • NAID

      120007129264

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cetuximab delivery and antitumor effects are enhanced by mild hyperthermia in a xenograft mouse model of pancreatic cancer.2016

    • Author(s)
      Miyamoto R, Oda T, Hashimoto S, Kurokawa T, Inagaki Y, Shimomura O, et al.
    • Journal Title

      Cancer Sci

      Volume: 107(4) Issue: 4 Pages: 514-520

    • DOI

      10.1111/cas.12888

    • NAID

      120007135356

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Well leg compartment syndrome after surgery for ulcerative colitis in the lithotomy position: A case report.2016

    • Author(s)
      Enomoto T, Ohara Y, Yamamoto M, Oda T, Ohkohchi N.
    • Journal Title

      International journal of surgery case reports.

      Volume: 23 Pages: 25-28

    • NAID

      120007135335

    • Related Report
      2016 Research-status Report
  • [Presentation] ポスト抗体医薬としてのがん糖鎖標的レクチンートキシン:膵癌の播種性転移治療を実用化する新規治療戦略2016

    • Author(s)
      小田竜也、下村 治、舘野浩章、平林 淳、野口雅之、浅島 誠、大河内信弘
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 高密度レクチンマイクロアレイを用いた膵癌幹細胞の糖鎖発現解析、未分化iPS細胞との偶然一致2016

    • Author(s)
      下村 治、小田竜也、舘野浩章、小澤佑介、野口雅之、浅島 誠、大河内信弘
    • Organizer
      第75回日本癌学会学術総会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-10-06
    • Related Report
      2016 Research-status Report
  • [Presentation] 変貌するレクチン科学と医療応用2016

    • Author(s)
      小田竜也、舘野浩章、山本一夫
    • Organizer
      第35回日本糖質学会年会
    • Place of Presentation
      高知市文化プラザ かるぽーと(高知県高知市)
    • Year and Date
      2016-09-01
    • Related Report
      2016 Research-status Report
  • [Presentation] 膵癌幹細胞とiPS細胞の類似性:網羅的糖鎖発現解析から偶然に炙りだされた共通性2016

    • Author(s)
      下村 治、小田竜也、舘野浩章、小澤佑介、稲垣勇紀、鄭 允文、平林 淳、浅島 誠、大河内信弘
    • Organizer
      第71回日本消化器外科学会総会
    • Place of Presentation
      あわぎんホール(徳島県徳島市)
    • Year and Date
      2016-07-14
    • Related Report
      2016 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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