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Analyses of regulatory B cell functions for tailor-made immunosuppression after liver transplantation

Research Project

Project/Area Number 16K10575
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionKyushu University

Principal Investigator

UCHIYAMA hideaki  九州大学, 医学研究院, 共同研究員 (70380425)

Co-Investigator(Kenkyū-buntansha) 調 憲  群馬大学, 大学院医学系研究科, 教授 (70264025)
吉住 朋晴  九州大学, 医学研究院, 准教授 (80363373)
池上 徹  九州大学, 大学病院, 講師 (80432938)
播本 憲史  群馬大学, 医学部附属病院, 講師 (00419582)
伊藤 心二  九州大学, 大学病院, 助教 (90382423)
副島 雄二  九州大学, 大学病院, 准教授 (30325526)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2016: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords肝移植 / 免疫寛容 / 調節性B細胞 / フローサイトメトリー / 免疫抑制剤 / 移植・再生医療 / 外科 / 免疫学
Outline of Final Research Achievements

The aim of this study was to reveal the functions of regulatory B cells after liver transplantation. Eighteen patients who underwent living donor liver transplantation were divided into the tolerant (TOL) group (in which an intentional reduction of immunosuppressants was successfully achieved; n = 4) and the stable (STA) group (in which a certain amount of immunosuppressants was needed in order to prevent rejection; n = 14). Five healthy volunteers participated in this study (HV group). Lymphocytes were extracted from blood of these 18 patients and 5 healthy volunteers. Then, the percentages of regulatory B cells were compared among the 3 groups by flowcytometry. The percentage of regulatory B cells was the highest in the HV group, and the lowest in the STA group. The result suggested that regulatory B cells had an important role for immune tolerance after liver transplantation.

Academic Significance and Societal Importance of the Research Achievements

肝臓は他の臓器と比較して、免疫寛容状態を作りやすいことが、動物実験や実臨床で証明されており、その寛容形成に調節性T細胞やB細胞が大きく関与していることが示唆されている。臓器移植後の免疫抑制剤の長期使用は悪性腫瘍の発生、糖尿病や高血圧の発症、易感染性など様々な不利益をもたらす。免疫寛容状態の機序が解明されれば、臓器移植患者は長期の免疫抑制剤使用から開放され、さらなる生活の質の向上に役立つことが期待される。本研究では、健常者と比較して肝移植を受けた患者の調節性B細胞の割合が低下していることを明らかにした。本研究から、肝移植後のさらなる調節性B細胞の機能解明に繋がることが期待される。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (1 results)

All 2019

All Presentation (1 results)

  • [Presentation] 調節性B細胞機能解明による肝移植後個別化免疫抑制療法の開発に向けた研究2019

    • Author(s)
      井口詔一
    • Organizer
      第55回日本移植学会総会
    • Related Report
      2018 Annual Research Report

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Published: 2016-04-21   Modified: 2020-03-30  

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