| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
The aim of this study was to clarify the clinical significance of HVEM expression in human colorectal liver metastasis (CRLM). We examined the cases of 104 patients with CRLM who underwent curative liver resection at Nara Medical University between 2000 and 2014. High HVEM expression was observed in 49 patients (47.1%) with CRLM. HVEM expression was not associated with age, gender, the administration of preoperative chemotherapy, tumor size, the number of tumors, or histological differentiation. The high HVEM group exhibited significantly worse overall survival (OS) than the low HVEM group (P=0.002). Multivariate analysis revealed that high HVEM expression in CRLM is an independent poor prognostic factor for OS (HR: 3.35, 95%CI: 1.41-7.93, P=0.006). The numbers of tumor-infiltrating CD8+ and CD45RO+ T cells were significantly lower in the high HVEM group than in the low HVEM group.
Conclusions. Tumor HVEM expression might play a critical role in CRLM.
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