| Project/Area Number |
16K10600
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
|
|---|
| Research Institution | Saga University (2017-2018)
Kyushu University (2016) |
|---|
Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
宮坂 義浩 九州大学, 大学病院, 助教 (40507795)
森山 大樹 九州大学, 大学病院, 准教授 (70586859)
江口 大樹 九州大学, 医学研究院, 共同研究員 (90726390)
池永 直樹 九州大学, 医学研究院, 共同研究員 (90759755)
|
|---|
| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 膵癌 / 膵癌微小環境 / 治療誘導性secretome / 治療抵抗性 / オルガノイド / 膵星細胞 / 微小浸潤 / 微小環境 / secretome |
|---|
| Outline of Final Research Achievements |
Secretome or activity of stromal remodeling may cause reftactory pancreatic cancer. The system of microenvironment around pancreatic cancer was examined regarding therapy-inducible secretome. Using our established microenvironment model, several secretomes affecting cancer invasion and migration were identified. In the future, secretome affecting treatment resistance would be identified as a final goal.
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| Academic Significance and Societal Importance of the Research Achievements |
今回の検討で癌の浸潤、遊走に関わるsecretome因子が複数同定できているので、治療抵抗性に関わるsecretome因子の同定を勧めていき、新たな治療戦略の一助になることを期待する。
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