Elucidation and control of the microemviroment of pancreatic cancer
Project/Area Number |
16K10600
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Digestive surgery
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Research Institution | Saga University (2017-2018) Kyushu University (2016) |
Principal Investigator |
|
Co-Investigator(Kenkyū-buntansha) |
宮坂 義浩 九州大学, 大学病院, 助教 (40507795)
森山 大樹 九州大学, 大学病院, 准教授 (70586859)
江口 大樹 九州大学, 医学研究院, 共同研究員 (90726390)
池永 直樹 九州大学, 医学研究院, 共同研究員 (90759755)
|
Project Period (FY) |
2016-04-01 – 2019-03-31
|
Project Status |
Completed (Fiscal Year 2018)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 膵癌 / 膵癌微小環境 / 治療誘導性secretome / 治療抵抗性 / オルガノイド / 膵星細胞 / 微小浸潤 / 微小環境 / secretome |
Outline of Final Research Achievements |
Secretome or activity of stromal remodeling may cause reftactory pancreatic cancer. The system of microenvironment around pancreatic cancer was examined regarding therapy-inducible secretome. Using our established microenvironment model, several secretomes affecting cancer invasion and migration were identified. In the future, secretome affecting treatment resistance would be identified as a final goal.
|
Academic Significance and Societal Importance of the Research Achievements |
今回の検討で癌の浸潤、遊走に関わるsecretome因子が複数同定できているので、治療抵抗性に関わるsecretome因子の同定を勧めていき、新たな治療戦略の一助になることを期待する。
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Report
(4 results)
Research Products
(9 results)
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[Journal Article] Extra-pancreatic invasion induces lipolytic and fibrotic changes in the adipose microenvironment, with released fatty acids enhancing the invasiveness of pancreatic cancer cells.2017
Author(s)
Okumura T, Ohuchida K, Sada M, Abe T, Endo S, Koikawa K, Iwamoto C, Miura D, Mizuuchi Y, Moriyama T, Nakata K, Miyasaka Y, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Oda Y, Hashizume M, Nakamura M.
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Journal Title
Oncotarget
Volume: 8
Pages: 18280-18295
DOI
Related Report
Peer Reviewed
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[Journal Article] Degree of desmoplasia in metastatic lymph node lesions is associated with lesion size and poor prognosis in pancreatic cancer patients.2017
Author(s)
Nakayama H, Ohuchida K, Yoshida M, Miyazaki T, Takesue S, Abe T, Endo S, Koikawa K, Okumura T, Moriyama T, Nakata K, Miyasaka Y, Shirahane K, Manabe T, Ohtsuka T, Toma H, Tominaga Y, Nagai E, Mizumoto K, Oda Y, Nakamura M.
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Journal Title
Oncol Lett.
Volume: 14
Pages: 3141-3147
DOI
Related Report
Peer Reviewed
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[Journal Article] Cancer-associated peritoneal mesothelial cells lead the formation of pancreatic cancer peritoneal dissemination.2017
Author(s)
Abe T, Ohuchida K, Koikawa K, Endo S, Okumura T, Sada M, Horioka K, Zheng B, Moriyama T, Nakata K, Miyasaka Y, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M.
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Journal Title
Surgery
Volume: 161
Pages: 951-958
DOI
Related Report
Peer Reviewed
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[Journal Article] Cancer-associated peritoneal mesothelial cells lead the formation of pancreatic cancer peritoneal dissemination.2017
Author(s)
Abe T, Ohuchida K, Koikawa K, Endo S, Okumura T, Sada M, Horioka K, Zheng B, Moriyama T, Nakata K, Miyasaka Y, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M.
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Journal Title
Int J Oncol.
Volume: 50
Pages: 457-467
DOI
Related Report
Peer Reviewed
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[Journal Article] Cancer-associated peritoneal mesothelial cells lead the formation of pancreatic cancer peritoneal dissemination.2016
Author(s)
Abe T, Ohuchida K, Koikawa K, Endo S, Okumura T, Sada M, Horioka K, Zheng B, Moriyama T, Nakata K, Miyasaka Y, Manabe T, Ohtsuka T, Nagai E, Mizumoto K, Hashizume M, Nakamura M.
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Journal Title
Int J Oncol
Volume: 50
Pages: 457-467
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Calpain inhibitor calpeptin suppresses pancreatic cancer by disrupting cancer-stromal interactions in a mouse xenograft model.2016
Author(s)
Yoshida M, Miyasaka Y, Ohuchida K, Okumura T, Zheng B, Torata N, Fujita H, Nabae T, Manabe T, Shimamoto M, Ohtsuka T, Mizumoto K, Nakamura M.
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Journal Title
Cancer Sci.
Volume: 107
Pages: 1443-1452
DOI
Related Report
Peer Reviewed
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[Presentation] Pancreatic organoids elucidate the new mechanisms of pancreatic cancer local invasion2017
Author(s)
K Koikawa, K Ohuchida, Y Ando, S Kibe, H Nakayama, S Takesue, Z Yan, T Abe, T Okumura, C Iwamoto, T Moriyama, K Nakata, Y Miyasaka, Y Okabe, T Ohtuka, K Mizumoto, M Nakamura
Organizer
The 48th Annual Meeting of The American Pancreatic Association
Related Report