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Development of hybrid surgery using irreversible electroporation (IRE) in pancreatic cancer

Research Project

Project/Area Number 16K10611
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Digestive surgery
Research InstitutionTokyo Medical University

Principal Investigator

Nagakaawa Yuichi  東京医科大学, 医学部, 准教授 (20349484)

Co-Investigator(Kenkyū-buntansha) 杉本 勝俊  東京医科大学, 医学部, 准教授 (20385032)
山口 浩  東京医科大学, 医学部, 准教授 (20510697)
土田 明彦  東京医科大学, 医学部, 主任教授 (50207396)
瀧下 智恵  東京医科大学, 医学部, 助教 (60774544)
Research Collaborator Itoi Takao  
Haga Sanae  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords膵癌 / 不可逆電気穿孔法 / IRE / 集学的治療 / 膵切除 / ハイブリッド手術 / 切除不能膵癌 / Borderline resectable膵癌
Outline of Final Research Achievements

We conducted a basic study using pigs to investigate the optimal treatment conditions for IRE. Based on that data, we performed a pilot-study of IRE treatment for patients with local advanced unresectable pancreatic cancer. Although the tumor shrank in all cases after IRE, the progression of cancer was observed in all cases. However, local progression in cases without distant metastasis was 12.0(8.5-15.3) months. In cases where distant metastasis can be controlled by chemotherapy, the effect of IRE treatment can be expected.

Academic Significance and Societal Importance of the Research Achievements

本研究では基礎的研究において膵癌治療におけるIREの最適な治療条件を同定することができた.また臨床研究の結果から局所進行切除不能膵癌においてIRE治療による局所コントロールは良好であり,化学療法にて遠隔転移が制御できる症例においてはIRE後に切除を行うことで更なる治療成績向上に繋がる可能性が示唆された.本研究結果はIREと切除のハイブリッド手術が将来的に有用となる可能性を示したと思われる.

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (3 results)

All 2019 2018

All Journal Article (3 results) (of which Peer Reviewed: 3 results)

  • [Journal Article] Neoadjuvant Therapy for Borderline Resectable Pancreatic Cancer: Is Combined Radiotherapy Necessary?2019

    • Author(s)
      Nagakawa Yuichi
    • Journal Title

      Annals of Surgical Oncology

      Volume: 26 Issue: 6 Pages: 1637-1638

    • DOI

      10.1245/s10434-019-07245-7

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Irreversible Electroporation for Nonthermal Tumor Ablation in Patients with Locally Advanced Pancreatic Cancer: Initial Clinical Experience in Japan2018

    • Author(s)
      Sugimoto Katsutoshi、Moriyasu Fuminori、Tsuchiya Takayoshi、Nagakawa Yuichi、Hosokawa Yuichi、Saito Kazuhiro、Tsuchida Akihiko、Itoi Takao
    • Journal Title

      Internal Medicine

      Volume: 57 Issue: 22 Pages: 3225-3231

    • DOI

      10.2169/internalmedicine.0861-18

    • NAID

      130007511592

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2018-11-15
    • Related Report
      2018 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Surgical Outcomes of Pancreaticoduodenectomy for Pancreatic Cancer with Proximal Dorsal Jejunal Vein Involvement.2018

    • Author(s)
      Hosokawa Y, Nagakawa Y, Sahara Y, Takishita C, Nakajima T, Hijikata Y, Osakabe H, Shirota T, Saito K, Yamaguchi H, Inoue K, Katsumata K, Tsuchiya T, Sofuni A, Itoi T, Tsuchida A.
    • Journal Title

      J Gastrointest Surg.

      Volume: 22 Issue: 7 Pages: 1179-1185

    • DOI

      10.1007/s11605-018-3722-0

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed

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Published: 2016-04-21   Modified: 2020-03-30  

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