Suppressed immune response following minimally invasive cardiac surgery
Project/Area Number |
16K10636
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular surgery
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Research Institution | Jichi Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
木村 直行 自治医科大学, 医学部, 准教授 (20382898)
吉崎 隆道 自治医科大学, 医学部, 研究員 (20743115)
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Project Period (FY) |
2016-10-21 – 2020-03-31
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Project Status |
Completed (Fiscal Year 2019)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 大動脈弁狭窄症 / 大動脈弁置換術 / 経カテーテル大動脈移植殖術 / 炎症反応 / サイトカイン / TAVI / 低侵襲心臓手術 / 経皮敵大動脈移植術 / 術後炎症反応 / 経皮的大動脈弁移植術 / 単球 / 好中球 / 循環器・高血圧 / 人工臓器 / 免疫学 |
Outline of Final Research Achievements |
We performed cytokine profiling in a surgical aortic valve replacement (SAVR) group (n=11) and transcatheter aortic valve implantation (TAVI) group (n=12). By measuring normalized concentrations of 71 cytokines at 3 time points, we found a significant difference (defined as fold change >1.7 and p <0.05) in 23 cytokines. The differentially expressed cytokines fell into 3 clusters: cluster A (high increase following SAVR and suppressed increase following TAVI only immediately after surgery [CCL2, 3 others]), cluster B (high increase following SAVR and suppressed increase following TAVI at 2 time points [IL-1Ra, IL-6, 7 others]), and cluster C (various patterns [IL-5, 10 others]). Gene enrichment analysis identified multiple pathways associated with the inflammatory responses in SAVR and altered responses in TAVI, including cellular responses to TNF (p = 0.0035) and IL-1 (p = 0.0062). A robust inflammatory response follows SAVR, and a comparatively attenuated response follows TAVI.
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Academic Significance and Societal Importance of the Research Achievements |
低侵襲心臓手術と通常の心臓手術における術後炎症反応の相違を、網羅的に解析した報告はごく稀であった。今回、国内外の他研究機関に先駆け、71個のサイトカイン濃度を、手術前・術直後・24時間後の3時相で計測し、TAVI手術の低侵襲性を炎症反応という視点から解析した。本研究でもIL-6などの炎症性サイトカイン濃度の発現抑制をTAVI群で確認した。さらに、TAVI群で発現減弱する炎症経路として、IL-1・TNFなどが同定された。 本研究成果は、TAVI手術の低侵襲性を分子レベルで明らかにするだけでなく、心臓手術の治療成績向上に向けた新規治療法開発の基盤となりうるものと考えられる。
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Report
(5 results)
Research Products
(8 results)
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[Journal Article] Effect of transcatheter aortic valve implantation on the immune response associated with surgical aortic valve replacement.2020
Author(s)
Kimura N, Nomura Y, Aomatsu A, Matsuda A, Imamura Y, Taniguchi Y, Hori D, Morishita Y, Fujita H, Yuri K, Matsumoto K, Yamaguchi A.
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Journal Title
American Journal of Cardiology
Volume: -
Pages: 35-44
DOI
Related Report
Peer Reviewed
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[Presentation] Transcatheter aortic valve replacement suppresses postoperative immune responses2019
Author(s)
Nomura Y, Kimura N, Aomatsu A, Matsuda A, Imamura Y, Taniguchi Y, Hori D, Shiraishi M, Sakakura K, Wada H, Fujita H, Morishita Y, Yuri K, Matsumoto K, Yamaguchi A
Organizer
American Heart Association Scientific Sessions 2019
Related Report
Int'l Joint Research
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