Establishing clinically relevant method of trans-esophageal motor evoked potential
Project/Area Number |
16K10656
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Cardiovascular surgery
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
|
Project Period (FY) |
2016-04-01 – 2020-03-31
|
Project Status |
Completed (Fiscal Year 2019)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | 脊髄虚血 / 運動誘発電位 / 外科 / 循環器:高血圧 / 脳・神経 |
Outline of Final Research Achievements |
Although trans-cranial motor evoked potential (TC-MEP) has been used to prevent ischemic spinal cord injury during aortic surgery, low specificity has been a problem. We have developed trans-esophageal motor evoked potential (TE-MEP) and have shown that it has a better specificity. As a clinically relevant method of TE-MEP, a novel method of bipolar trans-esophageal thoracic cord stimulation was developed, and its feasibility and utility were confirmed in an animal study. In a clinical study, TE-MEP can consistently be monitored after modification of a stimulation electrode and stimulation condition. Its specificity was better than that of TC-MEP. This result was presented at EACTS meeting in Lisbon (October 2019), and was published in EJCTS (doi:10.1093/ejcts/ezaa002).
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Academic Significance and Societal Importance of the Research Achievements |
大動脈外科手術に伴う虚血性脊髄障害は、生活の質のみならず生命予後をも不良とし、国家医療費の増大と患者・家族の負担を強いる重篤な合併症である。TC-MEPは不安定性や特異性の低さから、十分に普及していないが、TE-MEPにより、これらTC-MEPの問題点が解決されれば、大動脈外科手術中モニタリングの普及を通し、虚血性脊髄障害発生率低下に貢献することが出来る。
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Report
(5 results)
Research Products
(4 results)