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Development of regenerative medicine for refractory skin ulcers using fibroblasts

Research Project

Project/Area Number 16K10661
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Cardiovascular surgery
Research InstitutionYamaguchi University

Principal Investigator

SUZUKI Ryo  山口大学, 大学院医学系研究科, 助教 (10570319)

Co-Investigator(Kenkyū-buntansha) 濱野 公一  山口大学, 大学院医学系研究科, 教授 (60263787)
上野 耕司  山口大学, 医学部附属病院, 助教 (30736070)
Research Collaborator MIZOGUCHI Takahiro  
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords細胞移植 / 難治性皮膚潰瘍 / 再生医療 / 他家細胞シート / 細胞混合シート移植 / 細胞シート移植治療 / 移植・再生医療
Outline of Final Research Achievements

In examination of cell implantation using fibrin glue, cells were present on the surface of fibrin glue but not inside. This result suggested that implanted cells effectively come in contact with implantation sites. In ulcer mouse model, implantation of PBMNCs and fibroblasts using fibrin glue had a high therapeutic effect compared to implantation of cell sheet.

Academic Significance and Societal Importance of the Research Achievements

難治性皮膚潰瘍に対する新たな治療法として細胞移植治療があるが、皮膚潰瘍の形態は症例によって異なっている。そのため、本研究では、様々な皮膚潰瘍の形態に対応する細胞移植法としてフィブリングルーを用いた細胞移植法を検討した。本研究結果は、フィブリングルーを用いた末梢血単核球と線維芽細胞の移植は、細胞シートよりも治療効果が高い可能性を示唆した。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (2 results)

All 2018

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results)

  • [Journal Article] Autologous fibroblasts, peripheral blood mononuclear cells, and fibrin glue accelerate healing of refractory cutaneous ulcers in diabetic mice2018

    • Author(s)
      Mizoguchi T, Ueno K, Yanagihara M, Samura M, Kurazumi H, Suzuki R, Morikage N, Hamano K
    • Journal Title

      Am J Transl Res

      Volume: 10(9) Pages: 2920-2928

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Treatment of Cutaneous Ulcers with Multilayered Mixed Sheets of Autologous Fibroblasts and Peripheral Blood Mononuclear Cells2018

    • Author(s)
      Mizoguchi T, Ueno K, Takeuchi Y, Samura M, Suzuki R, Murata T, Hosoyama T, Morikage N, Hamano K
    • Journal Title

      Cell Physiol Biochem

      Volume: 47(1) Issue: 1 Pages: 201-211

    • DOI

      10.1159/000489767

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access

URL: 

Published: 2016-04-21   Modified: 2020-03-30  

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