Whole-body diffusion weighted imaging and pathogenesis for lung cancer
| Project/Area Number |
16K10694
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Kanazawa Medical University |
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Principal Investigator |
USUDA Katsuo 金沢医科大学, 医学部, 教授 (00324046)
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| Co-Investigator(Kenkyū-buntansha) |
道合 万里子 金沢医科大学, 医学部, 助教 (40515673)
上田 善道 金沢医科大学, 医学部, 教授 (50271375)
的場 宗孝 金沢医科大学, 医学部, 教授 (90288308)
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | MRI / MR拡散強調画像 / 肺癌 / 縦隔腫瘍 / 悪性胸膜中皮腫 / PET-CT / response evaluation / DWIBS / 予後因子 / 治療効果判定 / CT / RECIST / 全身性拡散強調 / 治療効果 / 診断精度 / 病期診断 / 全身性拡散強調画像 / 血管新生因子 / 血管新生遺伝子 |
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| Outline of Final Research Achievements |
Diagnostic efficacy by DWI for pulmonary nodules and masses and the evaluation of N factor and M factor in lung cancer are equivalent to or more than that of FDG-PET/CT. Evaluation by DWI for patients with multiple hilar and mediastinal lymph nodes with FDG accumulation is useful for distinguishing benign from malignant conditions. The diagnostic capability of whole-body DWI (WB-DWI) for the staging of clinically operable lung cancers is equivalent to that of FDG-PET/CT and brain MRI. ADC was not a significant prognostic factor that is correlated to T factor, N factor, or cell differentiation. Functional evaluation of DWI is better than that of CT for the response evaluation of chemotherapy and/or radiotherapy to recurrent tumors of lung cancer. The medical cost of MRI is 81-84% cheaper than that of FDG-PET/CT. MRI has no
radiation exposure and is preferable for the examinations of children.
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| Academic Significance and Societal Importance of the Research Achievements |
MR拡散強調画像 (magnetic resonance diffusion-weighted imaging, DWI）は、肺腫瘤の良悪性の鑑別診断、肺癌のN因子・病期診断、縦隔病変の良悪性の鑑別診断に有用である。また、MR拡散強調画像は、肺癌の再発病変に対する放射線・化学療法の治療効果の判定に、CTより有用である。MR拡散強調画像は、今後肺癌の質的診断で利便性が高く、炎症で偽陽性となるPET-CTの弱点を補うことが可能である。また、造影剤を使用しない全身性拡散強調画像DWIBSは、一度に全身の病変の検索が可能で、放射線被爆の問題がなく、患者の経済負担を軽減し、国民医療費の削減に貢献できる。
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Diagnostic Performance of Whole-Body Diffusion-Weighted Imaging Compared to PET-CT Plus Brain MRI in Staging Clinically Resectable Lung Cancer2016
Author(s)
Usuda K, Sagawa M, Maeda S, Motono N, Tanaka M, Machida Y, Matoba TM, Watanabe N, Tonami H, Ueda Y, Uramoto H.
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Journal Title
Asian Pac J Cancer Prev
Volume: 17 (6)
Pages: 2393-2398
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Diffusion-Weighted Imaging can differentiate pleural dissemination from malignant pleural mesothelioma, empyema or pleural effusion2018
Author(s)
Usuda K, Iwai S, Funasaki A, Sekimura A, Motono N, Matoba M, Doai M, Yamada S, Ueda Y, Uramoto H.
Organizer
International Cancer Imaging
Related Report
Int'l Joint Research
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