Therapeutic option for ALK-positive lung cancer targeting the chromosomal translocation based on chromoslipsis
| Project/Area Number |
16K10698
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory surgery
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| Research Institution | Chiba Cancer Center (Research Institute) |
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Principal Investigator |
Yokoi Sana 千葉県がんセンター(研究所), 遺伝子診断部, 部長 (30372452)
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| Co-Investigator(Renkei-kenkyūsha) |
Iizasa Toshihiko
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| Project Period (FY) |
2016-04-01 – 2019-03-31
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| Project Status |
Completed (Fiscal Year 2018)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 肺癌 / 染色体転座 / 癌 / 遺伝子 |
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| Outline of Final Research Achievements |
ALK inhibitors are effective for lung cancer with ALK translocation but become resistant within one year. In this study, genome-wide structural analysis of lung cancer with ALK translocation was performed, assuming that a reproducible genomic structural variation has occurred during the generation of chromosomal translocation on the chromosome 2 where ALK is located. As a result, we identified an ALK translocation-related gene that is located on the same chromosome 2 as ALK and causes reduced expression due to genomic deletion and promoter methylation. We also identified ALK translocation-related genes by bioinformatics analysis using an international cancer public database. These genes were considered to be potential therapeutic targets for lung cancer with ALK translocation.
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| Academic Significance and Societal Importance of the Research Achievements |
癌の中でも特に難治性で悪性度が高いALK転座肺癌において、転座を起こしている二番染色体には特定のゲノム構造異常が生じていることを明らかにした。また、これら二番染色体上の欠失や構造異常が、ALK転座肺癌症例において特定の遺伝子の発現を変化させることを明らかにした。ALK転座の近傍に座位し、発現制御異常をきたし、癌化や悪性度に関わるこれらの遺伝子は、ALK転座肺癌の治療標的候補であると考えられた。
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Report
(4 results)
Research Products
(19 results)
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[Presentation] 肺扁平上皮癌の予後に協調して関わる３つのマイクロRNA2016
Author(s)
Sana Yokoi, Endi Xia, Yusuke Suenaga, Sotaro Kanematsu, Hitomi Kondo, Noriko Otsuka, Yasumitsu Moriya, Toshihiko Iizasa, Ichiro Yoshino
Organizer
第75回日本癌学会学術総会
Place of Presentation
横浜
Year and Date
2016-10-06
Related Report
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