| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2018: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2017: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
ALK inhibitors are effective for lung cancer with ALK translocation but become resistant within one year. In this study, genome-wide structural analysis of lung cancer with ALK translocation was performed, assuming that a reproducible genomic structural variation has occurred during the generation of chromosomal translocation on the chromosome 2 where ALK is located. As a result, we identified an ALK translocation-related gene that is located on the same chromosome 2 as ALK and causes reduced expression due to genomic deletion and promoter methylation. We also identified ALK translocation-related genes by bioinformatics analysis using an international cancer public database. These genes were considered to be potential therapeutic targets for lung cancer with ALK translocation.
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