| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2018: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2017: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
We used laser-proteomics and laser-microdissection to identify molecules involved in the micro-invasion of Malignant Pleural Mesothelioma (MPM).
RNA was extracted from the invasive area and non-invasive area from the MPM sample, and a comprehensive gene analysis was performed. BAP1, NF2, NOTCH1, ABL1, ATM, CDKN2A, ERBB2, FBXW7, PTEN were identified as candidate genes from 12 samples. Furthermore, we decided the molecules (Noxa, MUC4, DAB2, Intelectin-1, Glypican-1, Survivin, BAP1, Mucin 21), which could differentiate MPM from lung adenocarcinoma and confirmed their clinical relevances.
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