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Inflammation Coupling between Unstable Carotid Plaque and Spleen Coupling A 18F-FDG PET study

Research Project

Project/Area Number 16K10712
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Neurosurgery
Research InstitutionUniversity of Toyama

Principal Investigator

KASHIWAZAKI Daina  富山大学, 大学院医学薬学研究部(医学), 助教 (50374484)

Co-Investigator(Kenkyū-buntansha) 黒田 敏  富山大学, 大学院医学薬学研究部(医学), 教授 (10301904)
桑山 直也  富山大学, 大学院医学薬学研究部(医学), 准教授 (30178157)
秋岡 直樹  富山大学, 附属病院, 講師 (70422631)
Project Period (FY) 2016-04-01 – 2019-03-31
Project Status Completed (Fiscal Year 2018)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2018: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2017: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2016: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
KeywordsInflammation / carotid stenosis / plaque / spleen / 不安定プラーク / 脾臓 / 慢性炎症 / 内頚動脈狭窄症 / プラーク / FDG-PET / 血管新生 / 脳神経疾患 / 脳血管障害学
Outline of Final Research Achievements

[Background and Purpose]This study was aimed to assess the hypothesis that unstable plaque formation in the carotid artery is one of phenotypes of chronic, systemic inflammation.[Methods]This study included eight symptomatic patients with internal carotid stenosis (ICS) and seven healthy controls. All subjects underwent 18F-fluorodeoxyglucos positron emission tomography (18F-FDG PET) of whole body. On 18F-FDG PET, the maximum standardized uptake (SUVmax) value was measured in the carotid plaque, spleen, liver, and bone marrow. [Results]All 8 patients in ICS group had unstable plaque on MRI. The SUVmax of spleen was significantly higher in ICS group than in the controls (3.20±0.25 and 2.51±0.40, respectively; P=0.003). The SUVmax ratio (spleen/liver) was also significantly higher in ICS group than in the controls (1.12±0.06 and 0.85±0.12, respectively; P=0.001). [Conclusion]These data strongly suggest the inflammation coupling between the spleen and unstable carotid plaque.

Academic Significance and Societal Importance of the Research Achievements

本研究で得られた知見は、同時に多動脈において動脈硬化が進行するpolyvascular diseaseを説明するうえで重要な機序である。また、動脈硬化が進行しそれぞれの臓器で発症するまでの過程を示した点で意義がある。

Report

(4 results)
  • 2018 Annual Research Report   Final Research Report ( PDF )
  • 2017 Research-status Report
  • 2016 Research-status Report
  • Research Products

    (14 results)

All 2019 2018 2017

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 4 results) Presentation (8 results)

  • [Journal Article] Efficacy of Carotid Endarterectomy for Mild (<50%) Symptomatic Carotid Stenosis with Unstable Plaque.2019

    • Author(s)
      Kashiwazaki D, Shiraishi K, Yamamoto S, Kamo T, Uchino H, Saito H, Akioka N, Kuwayama N, Noguchi K, Kuroda S.
    • Journal Title

      World Neurosurg.

      Volume: Jan;121 Pages: e60-e69

    • DOI

      10.1016/j.wneu.2018.09.013

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inflammation Coupling Between Unstable Carotid Plaque and Spleen-A 18F-Fluorodeoxyglucos Positron Emission Tomography Study.2018

    • Author(s)
      Kashiwazaki D, Yamamoto S, Akioka N, Kuwayama N, Noguchi K, Kuroda S.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: Nov;27(11) Issue: 11 Pages: 3212-3217

    • DOI

      10.1016/j.jstrokecerebrovasdis.2018.07.020

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxia accelerates intraplaque neovascularization derived from endothelial progenitor cells in carotid stenosis.2018

    • Author(s)
      Kashiwazaki D, Koh M, Uchino H, Akioka N, Kuwayama N, Noguchi K, Kuroda S.
    • Journal Title

      J Neurosurg.

      Volume: Oct 1 Issue: 3 Pages: 1-8

    • DOI

      10.3171/2018.4.jns172876

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of Plaque Composition on Risk of Coronary Artery Diseases in Patients with Carotid Artery Stenosis.2018

    • Author(s)
      Hamada S, Kashiwazaki D, Yamamoto S, Akioka N, Kuwayama N, Kuroda S.
    • Journal Title

      J Stroke Cerebrovasc Dis.

      Volume: Dec;27(12) Issue: 12 Pages: 3599-3604

    • DOI

      10.1016/j.jstrokecerebrovasdis.2018.08.031

    • Related Report
      2018 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxia Accelerates Intra-plaque Neovascularization Derived from Endothelial Progenitor Cells in Carotid Stenosis2018

    • Author(s)
      Kashiwazaki D, Koh M, Uchino H, Akioka N, Kuwayama N, Noguchi K, Kuroda S.
    • Journal Title

      Journal of Neurosurgery

      Volume: 印刷中

    • Related Report
      2017 Research-status Report
    • Peer Reviewed
  • [Journal Article] 内頚動脈狭窄症の不安定プラークにおける血管内皮前駆細胞と新生血管2018

    • Author(s)
      柏崎大奈
    • Journal Title

      脳神経外科速報

      Volume: 28 Pages: 258-263

    • Related Report
      2017 Research-status Report
  • [Presentation] 内頚動脈狭窄症不安定プラークの局所ならびに全身炎症の画像所見と病理像2019

    • Author(s)
      柏崎大奈、浜田さおり、山本修輔、白石啓太朗、齋藤久泰、秋岡直樹、桑山直也、野口 京、黒田 敏
    • Organizer
      第42回日本脳神経CI学会総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 不安定プラークはCEA/CAS前後のpolyvascular diseaseのリスク要因である2019

    • Author(s)
      柏崎大奈、浜田さおり、丸山邦隆、山本修輔、齋藤久泰、秋岡直樹、桑山直也、黒田 敏
    • Organizer
      第44回日本脳卒中学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 頚動脈狭窄症プラークにおけるM1マクロファージ高極性の発症における役割2019

    • Author(s)
      柏崎大奈、山本修輔、齋藤久泰、秋岡直樹、桑山直也、黒田 敏
    • Organizer
      第48回日本脳卒中の外科学会学術集会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 不安定プラークを有する内頚動脈狭窄症は慢性的な全身炎症と関連する2018

    • Author(s)
      柏崎大奈、浜田さおり、山本修輔、白石啓太朗、齋藤久泰、秋岡直樹、桑山直也、黒田 敏
    • Organizer
      第37回The Mt. Fuji Workshop on CVD
    • Related Report
      2018 Annual Research Report
  • [Presentation] 内頚動脈狭窄症不安定プラークにおけるマクロファージを中心とした臨床像2018

    • Author(s)
      柏崎大奈、山本修輔、齋藤久泰、秋岡直樹、桑山直也、黒田 敏
    • Organizer
      一般社団法人日本脳神経外科学会第77回学術総会
    • Related Report
      2018 Annual Research Report
  • [Presentation] 頚動脈プラークの不安定化は「全身の炎症」とよく相関している-18F-FDG PETによる研究2017

    • Author(s)
      柏崎大奈,山本修輔,内野晴登,秋岡直樹,桑山直也,黒田 敏
    • Organizer
      一般社団法人日本脳神経外科学会第76回学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 頚動脈プラークの不安定化は「全身の炎症」とよく相関している F-FDG PETによる研究2017

    • Author(s)
      柏崎大奈,山本修輔,内野晴登,秋岡直樹,桑山直也,黒田 敏
    • Organizer
      第60回日本脳循環代謝学会学術集会
    • Related Report
      2017 Research-status Report
  • [Presentation] 内頚動脈狭窄症のpositive remodelingは、頚動脈ステント留置術の虚血性合併症の危険因子である2017

    • Author(s)
      柏崎大奈,秋岡直樹,内野晴登,桑山直也,黒田 敏
    • Organizer
      第33回NPO法人日本脳神経血管内治療学会学術総会
    • Related Report
      2017 Research-status Report

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Published: 2016-04-21   Modified: 2020-03-30  

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